Griffin Lab

Structural biology lab @Bio21Institute @UniMelb led by Mike Griffin.

[Leann Tilley @LeannTilley]

Excited to see our study published in @PLOSPathogens. Multi-stage activity & single oral dose killing of P. falciparum in vivo. Structural basis for improved potency and selectivity of this reaction-hijacking inhibitor are revealed. https://t.co/VBgwchonnE

[The FEBS Journal @FEBSJournal]

💀The Garbers team @MHH_life characterise two clinically relevant variants in the #Interleukin-11 receptor gene & their roles in premature closure of 💀 bone sutures:

💀 https://t.co/5b4BdMLj1x
🔆 Commentary by @NatalieASims: https://t.co/2CgqFBu5Zk
#craniosynostosis

[Melbourne Protein Group @MelbProtein]

SAVE THE DATE! Excited to announce the 22nd Melbourne Protein Group Symposium will be hosted at WEHI on Thursday 11th July 2024. Spread the word to other graduate research/ student colleagues. Details of keynote speakers and abstract submission to come.

[Melbourne Protein Group @MelbProtein]

Don't miss out on your opportunity to attend and participate in Biomolecular Horizons 2024, held in Melbourne! 

YOUNG SCIENTIST PROGRAM- LAST CHANCE- application deadline extended to Friday 8 March @bmh2024Melb

https://t.co/7ww11FmP3J

[Griffin Lab @The_GriffinLab]

Great fun to work with @NatalieASims reflecting on new insights from the Garbers lab https://t.co/pE2DCBoj2x…, and open questions still to be answered surrounding craniosynostosis-associated variants in the IL-11 signalling machinery!
https://t.co/M4LfF2G54i

[Prof Natalie A Sims @NatalieASims]

Interleukin 11 (IL-11) receptor complex mutations are associated with craniosynostosis, but how does it happen? @The_GriffinLab and I had fun writing this editorial for @FEBSJournal based on new work from the Garbers lab - so much more to learn! https://t.co/Mi6WHXiGYx

[Griffin Lab @The_GriffinLab]

Great to see this beautiful work published today. And wonderful to be part of the global team advancing this amazing program!
https://t.co/BqLfcNJ4zf

[Leann Tilley @LeannTilley]

#Malaria parasites are specifically targeted by a new class of reaction-hijacking inhibitors. Targeting a tRNA charging enzyme, #OpenSourceMalaria compound causes parasites to self-destruct. An amazing collaborative effort from multiple sites across the globe. #Drugs #Parasites.

[Griffin Lab @The_GriffinLab]

@KazemAsadollahi @Danscooter @gnljameson Huge congrats Kazem!

[Griffin Lab @The_GriffinLab]

Really proud of this work published today understanding the assembly of the IL-11 signalling complex, dynamics of the gp130 receptor subunit, and how to inhibit IL-11 signalling. A brilliant collaboration! @riley_dm, @big_french_man, @PutoczkiLab.
https://t.co/gsbtcuTouE

[Griffin Lab @The_GriffinLab]

Congratulations Riley! Was quite a journey to get this out there - a huge credit to Riley for his hard work and determination.

[Rachel North @rachel_a_north]

Excited to share our reviewed preprint on a TRAP transporter https://t.co/9api2ZbVds in @eLife where an unexpected dimeric assembly was used to obtain a high-resolution structure. Big thanks to Michael Currie, @_jamesdavies and @dobson_lab, along with our fantastic collaborators!

[Leann Tilley @LeannTilley]

I am pleased that our review entitled: Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development, in Annual Review of Microbiology is now available Open Access. doi/10.1146/annurev-micro-032421-121210. @WinzelerLabUCSD @The_GriffinLab @IRBBarcelona @MalariaPapers

[Melbourne Protein Group @MelbProtein]

Open for registration. @RACI_VIC and MPG joint conference. To be held @RMIT. Register now CHEM 2023 / MPG (https://t.co/MUukSRv4Bx) and submit abstracts by 22nd Sept https://t.co/NLldqtJhay. Lots of speaking slots for #students and #ECRs

[Leann Tilley @LeannTilley]

Excited to see our #malaria pre-print https://t.co/3uTPhtQ6EV. An amazing collaborative effort from many sites across the globe to define the mechanism of action of a promising new class of reaction-hijacking inhibitors, targeting a tRNA charging enzyme in malaria parasites.

[Eric Hanssen @big_french_man]

We have a position open in the lab to take care of our SEMs and EDS workflow. ⁦@Bio21Institute⁩ ⁦@UniMelb⁩ Details : Technical Officer, Scanning Electron Microscopy https://t.co/MYMQaxuJKQ

[Melbourne Protein Group @MelbProtein]

PLACEHOLDER! MPG Symposium is being held late this year due to the exciting addition of combining with @RACI_VIC #CHEM2023. Whole meeting will run Tue 23rd Oct - Thurs 25th Oct. Keep your eyes peeled for more info... #protein

[Griffin Lab @The_GriffinLab]

Congratulations Cameron on a great PhD oration today!! @Bio21Institute @UniMelbMDHS @hayleyjnewton

[Leann Tilley @LeannTilley]

A thoughtful commentary on our nucleoside sulfamate antimalarial work and an insightful reflection on the history of nucleoside-based anti-infectives. I loved reading about the contributions of Gertrude Elion. https://t.co/JgYXg6xN9b. @odomjohnlab @SeshMDPhD #malaria

[Cell Host & Microbe @cellhostmicrobe]

Adenosine sulfamates: Next generation of #antimalarials. @odomjohnlab @SeshMDPhD highlight recent work of @LeannTilley @ScienceMagazine uncovering a class of nucleoside analogs that selectively hijack & inhibit tyrosine tRNA synthase of #malaria parasite https://t.co/AoJ6WpknT7

[Griffin Lab @The_GriffinLab]

Now highlighted in @TrendsParasitol:

Thwarting protein synthesis leads to malaria parasite paralysis

https://t.co/WCX0UMO1YU

[Griffin Lab @The_GriffinLab]

Fantastic to see this work identifying a new antimalarial strategy published. Proud and privileged to lead the structural biology with a global team headed up by Prof. @LeannTilley. Congratulations to all involved!
@UniMelb @Bio21Institute @TakedaPharma

https://t.co/zCgAphcztc

[Trends in Parasitology @TrendsParasitol]

Drs Godfrey Mayoka @jgwoodland & @Kelly_Chibale highlight Alexandra Gould @LeannTilley & colleagues’ recent @ScienceMagazine paper in this Spotlight: Thwarting protein synthesis leads to malaria parasite paralysis. @UCT_news @H3D_UCT @DiscoverJKUAT

https://t.co/4vRM9zis2T