Is oligometastatic prostate cancer becoming a distinct therapeutic state—or simply a consequence of better imaging?
Article 📰
https://t.co/LVYtoO3uUm
Oligometastatic prostate cancer — bridging the gap between localized and metastatic disease
Next-generation imaging, particularly PSMA PET–CT, is transforming the identification and management of oligometastatic #ProstateCancer . While metastasis-directed therapy can delay progression and systemic treatment in selected metachronous disease, its role in de novo oligometastatic cancer remains uncertain.
➡️Prostate-directed therapy is also under investigation alongside intensified systemic treatment.
✅Key challenges include defining oligometastatic disease, integrating biological selection, optimizing treatment sequencing, and establishing meaningful clinical endpoints.
@TheGiesen@EveraertsW@joniau@gertmeerleer@jaspervgou@karolien_goffin@GevaertThomas@OncoAlert 🚨 #LPCCC27
@Silke_Gillessen@AOmlin@ProfKHerrmann@weoncologists
Camrelizumab + rivoceranib vs direct surgery in resectable HCC at intermediate or high risk
@TheLancet
https://t.co/X8xoMllmDf
🔎CARES-009 phs 2/3
👉Perioperative cam + rivo doubles EFS
🧐Consistent pos. data for the combo, will be interesting to see whether & when approved in the West
@myESMO@EASLedu@ILCAnews
📊 Meta-analysis in mHSPC (>13,000 pts, 11 ph3 trials)
SoC (ADT±chemo) vs SoC + ARPI ± chemo
OS benefit ↓ with age HR 0.63 (<70y) vs 0.82 (≥70y)
Older pts ↑CV toxicity, ↑G3–5 AEs, ↑ discontinuations
In ≥70y low-vol mHSPC w/RT to the primary, ARPI adds little OS gain.
In ≥70y chemo or triplet Tx showed no OS gain
✅Tx choice must be guided by biology & fitness, not by age
https://t.co/cea4V2gVXP @OncoAlert
#ELCC25 program includes OS updates from MARIPOSA & LAURA in #EGFR NSCLC, adagrasib + pembrolizumab in #KRAS G12C, & final analysis from KEYNOTE 799 of pembrolizumab + chemoradiation in stage III NSCLC. Educational program highlights include AI session with Dr. @PrelajArsela
New article in press: Total neoadjuvant therapy with mFOLFIRINOX versus preoperative chemoradiotherapy in patients with locally advanced rectal cancer: long-term results of the UNICANCER-PRODIGE 23 trial. @GroupeUnicancer @icl_lorraine
https://t.co/DlPjBhLzGb
Even though we are in the era of targeted therapies, immunotherapies, and agnostic approaches, let's not forget that chemotherapy is still the cornerstone treatment for many tumors!
@CellCellPress@OncoAlert@OncBrothers@HemOncFellows@ASCO@myESMO
https://t.co/pReIKf9IlW