Tim Trobisch

Resident in Neurology | physician-scientist at @schirmerlab with a special focus on #SingleCell, heterogeneity of #NeuroGlia and #MultipleSclerosis

[Rahul Satija @satijalab]

Our free Single Cell Genomics Day workshop starts tomorrow at 10AM EST! You can ask watch the Youtube livestream at https://t.co/zG98gkcSCs. See you soon!

[Prof. Nikolai Slavov @slavov_n]

Let’s talk about proteins whose abundance generally does not correlate the abundance of the transcripts that templates them.

Give examples.

[Ming "Tommy" Tang @tangming2005]

People always ask how the protein is expressed if I show the RNA data. Here are the 6 resources for protein data 👇🧵

[Rahul Satija @satijalab]

Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on April 7. Talks will feature recent exciting computational and experimental advances and will be livestreamed at https://t.co/zG98gkckMU. Please RT/spread the word!

[Treutlein lab @TreutleinLab]

Save the date!

Single Cell Genomics 2023 #SCG2023 takes place Oct. 9-11 2023 in the beautiful mountain town Engelberg in Switzerland!

10th year anniversary of this unique experience. @IdoAmitLab, @slinnarsson, @AlexandervanOu1, @MarioniLab, @sandberglab, Aviv Regev, Amos Tanay

[Hannah Kapell @hannah_kapell]

Check out our latest work on targeting neuron-oligodendrocyte potassium shuttling at nodes of Ranvier as a neuroprotective approach in inflammatory demyelination @jclinicalinvest @schirmerlab

https://t.co/mZ0eu0nJaw

[Lucas Schirmer @schirmerlab]

Extremely happy that this piece is out! A wonderful multi-lab endeavor spearheaded by ⁦@hannah_kapell⁩ about neuron-oligodendrocyte potassium shuttling at nodes of Ranvier that protects against inflammatory demyelination ⁦⁦@jclinicalinvest⁩ https://t.co/XatinLuXHg

[Rahul Satija @satijalab]

Excited to share our preprint on multimodal single-cell sequencing to characterize antigen-specific CD8+ T cells across COVID vaccination and disease. We also release datasets profiling ATAC, RNA, protein, TCR and MHC dextramers at single-cell resolution:

https://t.co/3Eze06xHri

[Lucas Schirmer @schirmerlab]

Thrilled to share our work on spatial cell type mapping of MS lesions spearheaded by @Cels121 and ⁦@PauBadiaM⁩ | paired single-cell & spatial transcriptomics | Thanks ⁦@saezlab⁩⁩, Simon Hametner, ⁦@DenisSchapiro⁩ ⁦@cellbrowser⁩ https://t.co/w5Jcddsviy

[Ming "Tommy" Tang @tangming2005]

10 courses/books to learn bioinformatics 🧵👇

[Tim Trobisch @TimTrobisch]

@AlerieDe @schirmerlab Thanks Alerie!

[Tim Trobisch @TimTrobisch]

It was a great pleasure to present our latest data on cross-regional transcriptomic reactivity in MS @ECTRIMS - the first study to integrate three CNS regions on single cell resolution in human disease 🥳 many thanks for this opportunity @schirmerlab #ECTRIMS2022 #MS #SingleCell

[Lucas Schirmer @schirmerlab]

⁦@TimTrobisch⁩ rocked the poster session with a brilliant journey profiling #neuroglia cell types across the #CNS reporting novel #oligodendrocyte encoded #biomarkers in #MS - a fantastic endeavor that recently made it to paper, check it out: https://t.co/gHQY4H6HnS

[Dmitry Velmeshev @velmeshevlab]

Happy to share @Kriegsteinlab preprint on profiling human cortical development across prenatal and postnatal stages! Thanks to all co-authors, especially @Yonatan_Peretz, and @rebusbio @lab_paredes @cellbrowser @LabNowakowski @schirmerlab @mayersimo https://t.co/31uYGnemsO

[Ramon Massoni Badosa @rmassonix]

Do you want to get into scRNA-seq but are lost in the sea of never-ending papers?

No worries, I got you covered.

Here's a list of the best review that have help me understand the core concepts of the technique, analysis and interpretation:🧵

[Xiao Wang @WangXiaoLab]

Thrilled to share RIBOmap, a 3D in situ profiling method to detect mRNA translation for thousands of genes simultaneously in the context of subcellular architecture, cell types, and tissue anatomy led by @huzengHZ @jiahaoh511 @JingyiRen https://t.co/fHw7A7PscP

[Lucas Schirmer @schirmerlab]

Thrilled to share our latest work on cross-regional homeostatic and reactive glial signatures in multiple sclerosis | Spearheaded by ⁦@TimTrobisch and⁩ ⁦@AmelZulji⁩, big congrats to ⁦@schirmerlab⁩ ⁦@saezlab⁩ ⁦@velmeshevlab⁩ https://t.co/gHQY4H6HnS

[Itai Yanai @ItaiYanai]

If you don’t feel stupid doing science you’re not trying hard enough.

[Lucas Schirmer @schirmerlab]

Fantastic opportunity to dive deep into multiplexed spatial omics and apply novel spatially resolved transcriptomics and proteomics to inflamed tissues of muscle and brain! Drop us a line for more details and apply @DenisSchapiro and @schirmerlab @UniHeidelberg @ResearchLifesci

[Hongkui Zeng @HongkuiZeng]

I am pleased to share with you my review about cell types, published in @CellCellPress yesterday. 1/

What is a cell type and how to define it? https://t.co/HTZXZAU2iG

[Rahul Satija @satijalab]

We've released an Azimuth API that lets you process, map, and annotate your scRNA-seq dataset with a single R command. Just needs the raw counts matrix as input, and accepts Seurat objects, AnnData (h5ad), or hdf5 files.

Check out the vignette at: https://t.co/1ZF9cIG0rM