Tim Lohoff

Life Science Venture Capitalist @ForbionLifeSci | Ph.D. in Stem Cell Biology & Medicine from @Cambridge_Uni @ReikLab

[Ruslan Rust @rust_ruslan]

New preprint! 🚨@KeckMedicineUSC @uzh_irem

We started with the simple question: What happens when we transplant stem cells into a mouse model of #stroke, and what are the interactions between graft and host?

Took us only 5 yrs to find out😀:
https://t.co/35ywkirnKj

1/10 🧵

[Tim Lohoff @Tim_Lohoff]

@BowTiedBiotech @zhaoweiasu Have a look at the original publications and as I said, stay tuned and watch out for the space!

[Tim Lohoff @Tim_Lohoff]

@BowTiedBiotech @zhaoweiasu Seamless can program recombinases to almost any endogenous target site, without the need for a prior installed landing pad. The site-specific recombinases can ultimately catalyze inversions, insertions, excisions, and exchange reactions. Stay tuned!

[Tim Lohoff @Tim_Lohoff]

@BowTiedBiotech @zhaoweiasu Just to clarify, Seamless is using recombinase-based gene editing, not retrotransposons, even more versatile 💪🏼

[Tim Lohoff @Tim_Lohoff]

@luketgharland @wellcometrust @SCICambridge Great news and well deserved!!! 🥳

[Reik Lab @ReikLab]

New preprint! 🥳

https://t.co/DgHyEALuWB

Led by @AledJohnParry & @ChristelKrueger we asked why #DNAmethylation and oxidation often target overlapping genomic regions at the exit of #pluripotency.

Great collaboration with @Tim_Lohoff, @StevenWingett & @stefanschoenfe1.

🧵👇

[Tim Lohoff @Tim_Lohoff]

@shazanfar @GenomeBiology @RArgelaguet @ReikLab @SCICambridge @Cambridge_Uni @BabrahamInst Thanks, Shila 😊

[Tim Lohoff @Tim_Lohoff]

Happy to see another piece of my PhD work published in @GenomeBiology! 🥳 Amazing collaboration with @RArgelaguet and Stephen Clark 💪#DreamTeam Big thanks to everybody involved @ReikLab @SCICambridge @Cambridge_Uni @BabrahamInst! Finally, check out the great tweetorial below 👇:

[Tim Lohoff @Tim_Lohoff]

Great work @rust_ruslan and team! 🙌🐭

[Ruslan Rust @rust_ruslan]

Preprint 🚨 How does immune suppression alter the molecular 🧬 and anatomical 🧠 roadmap of #stroke pathology?

We detect distinct changes in different pharmacological and genetic immunodeficient models of stroked mice 🐭⚡️💉

Read more here: https://t.co/SJyNY55joW

🧵👇🏽 1/11

[Tim Lohoff @Tim_Lohoff]

@felix_lansing Congrats and best of luck 🥳

[Tim Lohoff @Tim_Lohoff]

@JTaubenschmid @CellStemCell Congrats Jasmin et al. 🥳 Great to see the final product!

[Tim Lohoff @Tim_Lohoff]

Wow 🤯 Congratulations @felix_lansing and team 🎉 Amazing work. Looking forward to following the path of designer-recombinases towards the clinic 🩸💪🏼 Keep the exciting work up! 🍀 Check out the great tweetorial below 👇

[Felix Lansing @felix_lansing]

Our work just got published in @NatureComms. We developed a dual designer-recombinase system that efficiently corrects a 140 kb inversion frequently found in patients with severe Hemophilia A. 1/11 @BuchholzLab_TUD @TakebeLab @tudresden_de @Medizin_TUD
https://t.co/JV5cFIlODQ

[Yodai Takei @yodai_takei]

Our work is out in @ScienceMagazine! Using integrated spatial genomics technology, we have extensively investigated the single-cell nuclear architecture across cell types in the mouse brain cortex with a great team @LongCai_Lab @gc_yuan @swzheng29 #seqFISH
https://t.co/vaqyya0IGN

[Shila Ghazanfar @shazanfar]

Incredibly happy to share that our work, co-led with @Tim_Lohoff is now available online at @NatureBiotech 🎉

Feeling very grateful to everyone who was involved in this project 🙏

Explore the data here: https://t.co/19sRiZEQ6W

[Reik Lab @ReikLab]

Paper alert! 🎉 By combining SeqFISH and scRNA-seq data we've generated a spatially-resolved map of cell types and gene expression in the early mouse embryo. https://t.co/D1kMl3BOhz

[Tim Lohoff @Tim_Lohoff]

@RichTyser @shazanfar Thanks for all your help! 💪 #TeamWork

[Tim Lohoff @Tim_Lohoff]

@felix_lansing @ReikLab Thanks Felix 🙏

[Cai Lab @LongCai_Lab]

Our work "Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis" is now out at @NatureBiotech ! Congratulations to all the authors! https://t.co/3edEDr4pdu #seqfish #spatial #singlecell #transcriptomics

[Nature Biotechnology @NatureBiotech]

Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis https://t.co/WCAYYlhNOT

[Tim Lohoff @Tim_Lohoff]

@hackettlab @ReikLab @A_Abakir Thanks Jamie!