New preprint! 🚨@KeckMedicineUSC @uzh_irem
We started with the simple question: What happens when we transplant stem cells into a mouse model of #stroke, and what are the interactions between graft and host?
Took us only 5 yrs to find out😀:
https://t.co/35ywkirnKj
1/10 🧵
@BowTiedBiotech@zhaoweiasu Seamless can program recombinases to almost any endogenous target site, without the need for a prior installed landing pad. The site-specific recombinases can ultimately catalyze inversions, insertions, excisions, and exchange reactions. Stay tuned!
New preprint! 🥳
https://t.co/DgHyEALuWB
Led by @AledJohnParry & @ChristelKrueger we asked why #DNAmethylation and oxidation often target overlapping genomic regions at the exit of #pluripotency.
Great collaboration with @Tim_Lohoff, @StevenWingett & @stefanschoenfe1.
🧵👇
Preprint 🚨 How does immune suppression alter the molecular 🧬 and anatomical 🧠 roadmap of #stroke pathology?
We detect distinct changes in different pharmacological and genetic immunodeficient models of stroked mice 🐭⚡️💉
Read more here: https://t.co/SJyNY55joW
🧵👇🏽 1/11
Wow 🤯 Congratulations @felix_lansing and team 🎉 Amazing work. Looking forward to following the path of designer-recombinases towards the clinic 🩸💪🏼 Keep the exciting work up! 🍀 Check out the great tweetorial below 👇
Our work just got published in @NatureComms. We developed a dual designer-recombinase system that efficiently corrects a 140 kb inversion frequently found in patients with severe Hemophilia A. 1/11 @BuchholzLab_TUD@TakebeLab@tudresden_de @Medizin_TUD
https://t.co/JV5cFIlODQ
Our work is out in @ScienceMagazine! Using integrated spatial genomics technology, we have extensively investigated the single-cell nuclear architecture across cell types in the mouse brain cortex with a great team @LongCai_Lab@gc_yuan@swzheng29#seqFISH
https://t.co/vaqyya0IGN
Incredibly happy to share that our work, co-led with @Tim_Lohoff is now available online at @NatureBiotech 🎉
Feeling very grateful to everyone who was involved in this project 🙏
Explore the data here: https://t.co/19sRiZEQ6W
Paper alert! 🎉 By combining SeqFISH and scRNA-seq data we've generated a spatially-resolved map of cell types and gene expression in the early mouse embryo. https://t.co/D1kMl3BOhz
Our work "Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis" is now out at @NatureBiotech ! Congratulations to all the authors! https://t.co/3edEDr4pdu #seqfish#spatial#singlecell#transcriptomics