Vivek Dwivedi

Post-doctoral C. elegans researcher, Horvitz Lab@MIT

[Vivek Dwivedi @VKDBiologist]

A few cells get kicked out from a C. elegans embryo defective in caspase-mediated apoptosis during the beautifully orchestrated dance of development .

Find out why here: https://t.co/p3Fyj65Joy

[Vivek Dwivedi @VKDBiologist]

My paper on cell extrusion is out in print in the 27th May issue of @Nature ! Have you read it? Did you like it? Have you #SharedIt ? Here’s the free link: https://t.co/qMVzJREQ5k .Please spread the word - RT! #sciart #CellBiology #Microscopy #FluorescenceFriday @MITBiology

[Hitoshi Sawa @dpyNonunc]

なぜ細胞は不均等分裂の後で死ぬのか？
https://t.co/z7vDRdF8Zh
My @Facultyopinions evaluation about the exciting paper by @VKDBiologist.
https://t.co/evGVBzPOqO

[Hitoshi Sawa (En) @uncNondpy]

My @FacultyOpinions evaluation about the exciting paper by @VKDBiologist "Replication stress promotes cell elimination by extrusion"
A reason for cells to die after unequal cell divisions. https://t.co/rgLPhJo9qx

[Vivek Dwivedi @VKDBiologist]

Please RT: an excellent research highlight of our article (https://t.co/p3Fyj65Joy, free: https://t.co/nflscmWszE) on replication stress in cells triggering their elimination by extrusion. #Microscopy #CellBiology #ScienceTwitter #CancerResearch #devbio #scienceisfun

[Nature Reviews Molecular Cell Biology @NatRevMCB]

Now Online Replication stress as a trigger for cell extrusion https://t.co/E1VVzUwJDS

[Vivek Dwivedi @VKDBiologist]

@AgnelSfeir Thank you Agnel!

[Vivek Dwivedi @VKDBiologist]

A few cells get kicked out from a C. elegans embryo defective in caspase-mediated apoptosis during the beautifully orchestrated dance of development .

Find out why here: https://t.co/p3Fyj65Joy

[Vivek Dwivedi @VKDBiologist]

@BurtonNick @VAInstitute This is great news, Nick! Congratulations!!

[Vivek Dwivedi @VKDBiologist]

@AATBioquest @MITBiology Thank you AAT Bioquest!

[Vivek Dwivedi @VKDBiologist]

Cells extruding from a C. elegans embryo. Read how cells get extruded because they enter the cell cycle and get stuck copying their DNA: https://t.co/p3Fyj65Joy. (Free here: https://t.co/nflscmWszE) Already read and liked it? RT! @MITBiology #SciArt #CellBiology

[Vivek Dwivedi @VKDBiologist]

Excellent news Yadira! Congratulations!!

[Patrick Hu @patrickhu]

Another basic developmental process relevant to cancer revealed in #celegans @NIH @NIHDirector @NCIDirector @VUMCHemOnc @VUMC_Cancer

[Vivek Dwivedi @VKDBiologist]

@_lecote_ I think it’s a consequence of being small. But regarding forcing cell division, it would likely need to be done before epidermal enclosure, as the extrusions that we see are only of cells otherwise fated to die by CED-3 before enclosure. The “window” to extrude closes after.

[Vivek Dwivedi @VKDBiologist]

@AdamsBioAging As an author, I couldn’t have wished for a better description! Thank you, Peter!

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

The best papers are the simplest——Replication stress promotes cell elimination by extrusion | Nature https://t.co/76WZ1xRngs

[Vivek Dwivedi @VKDBiologist]

@_lecote_ So it seems the determination of the same cells for the death process might be independent of replication stress. I also think that cells killed by CED-3 in WT don't even get a chance to enter the cell cycle.

[Vivek Dwivedi @VKDBiologist]

@_lecote_ Great question, Lauren! We tested RNAi against cell-cycle genes that promote extrusion in ced-3 mutant animals in a wild-type background for the cell death, but did not see an effect. This suggests that replication stress does not contribute to CED-3-mediated cell death in WT.

[Vivek Dwivedi @VKDBiologist]

@_lecote_ Thank you, Lauren! I am glad you remember our conversations. Yes, S-phase regulators were indeed confusing and there were so many possible explanations at the time. But fluorescent cell-cycle reporters combined with RNAi made very clear what was going on.

[Vivek Dwivedi @VKDBiologist]

@MartinLabMIT Thank you Adam!

[Vivek Dwivedi @VKDBiologist]

@BurtonNick Thank you, @BurtonNick ! Hope you liked the paper.

[Vivek Dwivedi @VKDBiologist]

Cc: @MITBiology