Vijay K. Yadav (VJ)

Scientist investigating the biology of aging

[Vijay K. Yadav (VJ) @VijayYadavLab]

New in @sciencemagazine we report a role of taurine deficiency as a driver of aging.
https://t.co/lVd5w4SoEr
https://t.co/eqx9F8hXdE
I thank all the collaborators and funders as well as my present and past institutions in USA, UK and India for supporting my team.

[Mike Lustgarten, PhD @mike_lustgarten]

A null mutation in SERPINE1 protects against biological aging in humans

https://t.co/gAuMJVSoOo

[Dr. Catharine Young @DrCatharineY]

The hill I will die on - we have to rethink graduate training.

“Scientists are trained for a world where data speaks for itself. Where misinformation moves slowly. Where scientific expertise naturally rises above noise. That world is gone.”

https://t.co/hWv5M8SQjk

[Matt Kaeberlein @mkaeberlein]

Finally—this is the kind of study the field has been waiting for.

A 720-person randomized clinical trial testing low-dose rapamycin in adults 65+ is about to get underway at @UAZPharmacy , with the goal of answering a simple but critical question: can we actually improve healthspan in humans?

In this episode, I sit down with Dr. Bonnie LaFleur to break down the design, the science, and why this trial is different:

• Real clinical endpoints (frailty + inflammation)
• Long-term follow-up (years, not weeks)
• Deep phenotyping—genetics, epigenetics, immune profiles, and more
• Early data suggesting no major safety signals at weekly dosing

We also dig into what we still don’t know—pharmacokinetics, individual variability, and whether rapamycin can truly shift the trajectory of aging in people.

This is a big moment for the field. Not hype. Not speculation. Data.

🎧 Full episode here: https://t.co/3NQmcAr6s1

[Vijay K. Yadav (VJ) @VijayYadavLab]

@HeWaHippo https://t.co/UAmxWNO9qZ

[Vijay K. Yadav (VJ) @VijayYadavLab]

#Taurine supplementation, #methionine restriction, and moderate exercise synergistically #extendslifespan while preserving reproductive capacity in Drosophila. This suggests that uncoupling the traditional trade-off between lifespan and functional #health is feasible.

[Vijay K. Yadav (VJ) @VijayYadavLab]

@HeWaHippo We investigated this metabolomic connection sometime ago. What pathways it corrects downstream of methionine remains to be seen. Here is a link. https://t.co/OHe2Ixy4oS
https://t.co/xuhdd01RXt

[Vijay K. Yadav (VJ) @VijayYadavLab]

https://t.co/0n0ojWyaxP

[Vijay K. Yadav (VJ) @VijayYadavLab]

Key metabolites predictive of biological aging, such as #taurine and citrate, were not captured by traditional age analyses, pointing to their potential role as #biomarkers for #healthyaging.

[Vijay K. Yadav (VJ) @VijayYadavLab]

Metabolomic signatures of extreme old age in human: New England Centenarian Study. https://t.co/gTto0FHdA3

[Toru Takumi @ToruTakumi]

Happy to share my students’ study
@CellReports
Parvalbumin interneurons in the insular cortex control social familiarity and emotion recognition: Cell Reports https://t.co/ODnv6hVQV7

[Vijay K. Yadav (VJ) @VijayYadavLab]

Tried my hands on making, in a healthy way, Bhuna Gosht (Goat meat) for Saturday dinner. My son enjoyed it with rice and home made roti and said it is the best meat he has ever had, which made up for all the efforts!!

[Vijay K. Yadav (VJ) @VijayYadavLab]

@LabSpiegelman Rest in peace. Dave was a wonderful scientist, always ready to provide his scientific insights with amazing historical background.

[Vijay K. Yadav (VJ) @VijayYadavLab]

Taurine levels correlate with thyroid function in humans and taurine supplementation shows beneficial effects on thyroid functions in animal models. Will it do the same in humans? https://t.co/rg17yBUlUm
https://t.co/pRvr8hfTag

[Rutgers Health @rutgershealth]

A Rutgers study finds people use 100+ chemicals daily through personal care products, some linked to cancer & hormone disruption. The good news? Safer choices = lower exposure.
Learn how to reduce your risk: https://t.co/RFPE6tcjhi

[Vijay K. Yadav (VJ) @VijayYadavLab]

#Taurine as a potential #prophylactic or #therapeutic agent to reduce symptomatic #malaria
https://t.co/NpmjkD0XI5

[Vijay K. Yadav (VJ) @VijayYadavLab]

#Nonuniversality of #inflammaging across #human populations. Wonderful work from Alan Cohen @ColumbiaAging https://t.co/0KAVPGt85W

[Vijay K. Yadav (VJ) @VijayYadavLab]

@MissLadyLee Taurine supplementation makes animals live longer (worms, mice) and healthier (worms, mice, monkeys), and conversely if you make animals taurine-deficient they have poor health and have 40% shorter lifespan. For details putting the setudies in context see: https://t.co/6omEPOyDMM

[Vijay K. Yadav (VJ) @VijayYadavLab]

A reccent important study in the area of taurine biology by De Cabo's group provides new insight into changes in blood taurine levels in humans. In response to requests and tags I thought I will provide my point of view. @NirBarzilaiMD @davidasinclair @EricTopol @mkaeberlein

[Vijay K. Yadav (VJ) @VijayYadavLab]

Long road from #animal research to #humans. #Taurine was first noted as beneficial for stroke and #cardiovascular diseases prevention in stroke-prone spontaneously #hypertensiverats. Okamoto K et al., Jpn Circ J. 1963, 27: 282-293.
For further read: https://t.co/hdGuWXfM5Y

[Vijay K. Yadav (VJ) @VijayYadavLab]

#Taurine ameliorates #blood pressure and #vascular function in patients with type 2 #diabetes: Randomized, double-blind, placebo-controlled clinical trial. https://t.co/zQJkMAaReO

[Vijay K. Yadav (VJ) @VijayYadavLab]

For further read please see: https://t.co/6omEPOzbCk

[Vijay K. Yadav (VJ) @VijayYadavLab]

A reccent important study in the area of taurine biology by De Cabo's group provides new insight into changes in blood taurine levels in humans. In response to requests and tags I thought I will provide my point of view. @NirBarzilaiMD @davidasinclair @EricTopol @mkaeberlein

[Vijay K. Yadav (VJ) @VijayYadavLab]

Nice to see some media outlets stay with available scientific evidences when writing news articles. https://t.co/rLJobxsrZ3