Tom Vondriska

Chromatin, heart disease, and other stuff
see thomasvondriska dot substack dot com

[Tom Vondriska @VondriskaLab]

What to think about

https://t.co/AaOMUO3amn

[Dr David Vernon @DrDavidVernon]

i’d forgotten this line, 11 pages into 1984…

[Oded Rechavi @OdedRechavi]

Most experiments fail, and negative results rarely get published. This means LLMs are unaware of the outcomes of most experiments.

[Tom Vondriska @VondriskaLab]

@pmarca this may be fine for Martin Scorsese and you'll get your 100 more movies before he dies. but how will the next Scorsese learn to create?

[Tom Vondriska @VondriskaLab]

https://t.co/peVaxo5Fq6

[Alby Mengele @David_____1]

This is becoming one of my favorite series of tweets

[Tom Vondriska @VondriskaLab]

@andrewwhite01 @Nature @agreeb66 did you consider just pushing it out on internet and not publishing? to avoid the delay?

[Tom Vondriska @VondriskaLab]

@mbeisen @Nature or it shows they are using the existing medium to transcend it

[David Braun @BraunMDPhD]

We are hiring! We are specifically looking for a postgraduate associate - someone who has recently finished university and is ultimately looking to apply to medical school or graduate school.

It is a TWO YEAR clinical/translational position, where you will be interacting closely with patients, involved in translational clinical trials, and working hands on in the lab and with clinical databases.

The ideal candidate is a great communicator, organized, and enthusiastic about patient-oriented clinical and lab research. You will get dedicated mentoring not just on the science and clinic, but also on career/professional development as well.

We are looking for someone to start ASAP! More information here:
https://t.co/RgV4lJw4OM

Please help to spread the word and RT!
@DrChoueiri @VanAllenLab @tompowles1 @YaleCancer @YaleMed @SmilowCancer @kidneycan @OncoAlert @OncLive @KidneyCancer @A_P_S_A @cure_today @yalepathology @Yale_Urology @DrYukselUrun @MarkDSiegel1 @OncBrothers @DrKarineTawagi

[Thomas Massie for Congress @MassieforKY]

I did not see this coming, but my election has become an inflection point for our whole country. Today we make history.

Will you be part of this historic day by voting, calling friends who can vote, posting to social media, or making a donation?

Spread the word fellow patriots!

[Jason Sheltzer @JSheltzer]

My lab at @Stanford is looking to hire postdocs for multiple projects on cancer biology and therapeutics. Our recent work has uncovered some truly remarkable mechanisms for cytotoxic small molecules and we're looking to build on this research. If interested, see below:

[Thomas Massie for Congress @MassieforKY]

In less than four days, our Moneybomb has reached $847,950 thanks to thousands of patriots across the country.

Soon we will buy the final tv ads & mail pieces for the last week of the campaign.

https://t.co/r10M5btnhD is still live and
these donations are critical. Thank you!

[Department of Medicine at UCLA Health @DOM_UCLA]

Congratulations to Dr. Aditya Bardia on his election to the American Society for Clinical Investigation! A leader in precision medicine, Dr. Bardia’s innovative work in antibody-drug conjugates and liquid biopsies is transforming cancer care. Learn more: https://t.co/152LvxOwNC

[Javid Moslehi @CardioOncology]

Excited to announce this special fellowship in #CardioImmunology at UCSF! @UCSFCardiology @UCSF @Cytokinetics @AHAScience @NatureCVR @trogersresearch @CircAHA @RocketPharma @UCSFMedicine

[Abberior @Abberior]

DNA is not static inside the nucleus, and its dynamics play a crucial role in gene activation and DNA repair. By combining MINFLUX with conventional tracking methods, Mazzocca et al. have now resolved chromatin motion across an exceptional dynamic range—from microseconds to minutes:
https://t.co/sKG1DAZWun

🔬 Key findings:
• Chromatin exhibits highly constrained, subdiffusive motion
• Local DNA regions can interact rapidly
• Long-range interactions occur very slowly and are therefore limited
• Structural features such as loop extrusion strongly restrict mobility

Congratulations to Matteo Mazzocca, Anders S. Hansen and all authors for refining our understanding of genome organization and its impact on gene regulation and DNA repair.

[Julio Frenk @UCLAchancellor]

At @UCLA, Dr. Donald Kohn's research is helping improve gene therapy for sickle cell disease by finding better ways to prepare patients for treatment. This condition affects about 100,000 people in the U.S. and millions worldwide. #ResearchPowersProgress https://t.co/DbTostI3hV

[Department of Medicine at UCLA Health @DOM_UCLA]

Congratulations to Dr. Dennis Slamon on his election to the Association of American Physicians! His groundbreaking discoveries, including the development of Herceptin, have saved millions of lives and revolutionized cancer care. Read the full story here: https://t.co/6CHymiiUAk

[Tom Vondriska @VondriskaLab]

Update on talking to whales

[Interspecies Internet @Interspecies_io]

⭐️ @projectceti: New Paper!

“The phonology of sperm whale coda vowels” shows whales produce vowel-like sounds organized in patterns, akin to human phonology.

Learn more here: https://t.co/G5q1ISYcgG

[Tom Vondriska @VondriskaLab]

@LocasaleLab both statements could be true...with some specific context. hers was wildly devoid of any context and your rebuttal missed an opportunity to provide it. 'aberrant glucose metabolism' does little to explain how one should think about proper management of an essential molecule

[Tom Vondriska @VondriskaLab]

Check check a Netter book out of from library

[Sharon Goldman @sharongoldman]

Me: I am very impressed with the new OpenAI image model. Wowza.

My sister, professor of anatomy at a med school: "Ask it to create an anatomically correct labeled image of the human thorax."

Me: ok! Here it is. How is it?

Sister: Oy.

Me: what's wrong with it?

Sister: It has a giant extra set of veins going to the upper lobe of the left lung. The arch of the aorta is way too low. The costal cartilage label is pointing to the lungs. The labels are pointing all wrong. The label to the trachea is pointing to the thyroid gland. The heart label is pointing to the sternum and so on and so forth. I think the leaders on the labels all pointing to the wrong things are the weirdest thing

Me: it's still cute tho

Sister: Oh and there are some crazy bones coming out the side of the neck above the first rib.

Me: 🙂

[Aaron Gwyn @AmericanGwyn]

My Advanced Readers Edition of NO COUNTRY FOR OLD MEN that Knopf sent me when I reviewed it in 2005. It differs in really interesting ways from the finished version of Cormac’s novel. (Apparently these go for big money now).