Walter Muskovic

Post-doctoral researcher @ Garvan Institute of Medical Research, using single-cell sequencing to investigate the brain cancer glioblastoma.

[Anna Cuomo @AnnaSECuomo]

Check out our latest work, introducing SAIGE-QTL, a new robust and scalable method for single-cell eQTL mapping! Tweetorial by the amazing @weizhouw👇

[Walter Muskovic @WalterMuskovic]

@Miguel_RuizC @drjosephpowell Hi @Miguel_RuizC it's hard to define a 'normal' range as different cell types vary in their nuclear fraction values. I'd recommend comparing NF values within all cells of a given type to identify cell-free droplets/damaged cells

[Manu Saraswat @manusaraswat10]

Want to apply #deeplearning in your #regulatory #genomics analyses but overwhelmed by suite of interpretation tools? Check out ExplaiNN: interpretable and transparent neural networks for genomics with @NovakovskyG @ofornes @sara_mostafavi @WyWyWa 🧵👇
https://t.co/DwzQ6Jiqnm

[Annabel Crabb @annabelcrabb]

Australian women took a good look at the prime ministerial bulldozer... and sent him a John Deere letter. Here's my column on why https://t.co/IjkqjaDpiK

[ElowitzLab @ElowitzLab]

Many intercellular communication systems (BMP, Notch, Wnt, FGF, etc) use sets of promiscuously interacting ligand and receptor variants rather than seemingly simpler one-to-one architectures. Why? Our 2 papers grappling w/this question just out in @CellSystemsCP

[Seyhan Yazar @seyhanyazar]

Excited to share our work on single cell eQTL mapping of OneK1K Cohort (1000 individuals 1000 cells) that’s just published in @ScienceMagazine. Thanks to our amazing team @josealquicirah, @WingKristof, @FairfaxKirsten, @MGraceGordon, @yimmieg, @AlexWHewitt and @drjosephpowell!

[Joseph Powell @drjosephpowell]

Our work “Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease” just published in @ScienceMagazine. The work started with the creation of the OneK1K cohort, consisting of scRNA-seq data on PBMCs from ~1000 donors https://t.co/Uzskay7TeM 🧵

[Walter Muskovic @WalterMuskovic]

@ChiragNepal @tangming2005 I don't think MALAT1/NEAT1 enrichment is a consequence of cell damage. I think the pool of RNA becomes depleted of cytoplasmic transcripts lost through the damaged cell membrane, so the nuclear-retained transcripts will make up more of the pool of sequenced RNA from those cells

[Eric Lam @EricCELam]

This is the way..

[Blake Robert Mills @BlakeRobMills]

✨✨ PACKAGE UPDATE ✨✨
MetBrewer 0.2.0 is officially out 🥳 Available both on Cran and through my GitHub here: https://t.co/wYHMEKoJLH

New Palettes are out and some amazing new features. Full description of what has changed below :)

#MetBrewer #rstats #r4ds #dataviz

[Drew Neavin @drneavin]

Have you ever wondered which demultiplexing and doublet detection methods to apply to your single-0cell dataset? Wait no more! We've developed Demuxafy, an easy-to-use software platform to support method selection and execution for single-cell demultiplexing and doublet removal.

[Joseph Powell @drjosephpowell]

Introducing Demuxafy: Improvement in droplet assignment by integrating multiple single-cell demultiplexing and doublet detection methods. Work led by @drneavin as part of the sceQTL-gen consortium https://t.co/Dr8qOmjpWF

[Ming "Tommy" Tang @tangming2005]

1/ single-cell RNAseq data matrix is sparse. dominant 0s makes gene-gene correlation calculation hard. Tools that I know to tackle this problem #scRNAseq :
https://t.co/6LfiwAIXUU

[Walter Muskovic @WalterMuskovic]

@drjosephpowell Link to the paper here :)
https://t.co/OGxYQyoVBb

[Walter Muskovic @WalterMuskovic]

Great response so far to the autoimmune community survey, check it out if you haven't already
https://t.co/9XFFSTsTx3
#Spoonie #ChronicIllness #Autoimmune #InvisibleIllness #NEISvoid

[Gene Networks in Disease @GND_crew]

Milestone alert 🚨 the #ChronicIllness #PatientAdvocacy project has hit 1000 participants!

Thank you all for chronicling 162 illnesses, snapshot below where text size = number of responses.

Sneak peek of what your responses are showing us, a 🧵… 1/

#InvisibleIllness #NEISvoid

[Anna Liza Kretzschmar @hydra_hamster]

12% of #Australians suffer from #ChronicIllness

#DiagnosticJourneys can be long, hard & exhausting

#Spoonie voices are often unheard in #research

#PatientExperience & practice is key for precise research, yet many feel unheard, alone & defeated

#SVCRS2021 1/

[Walter Muskovic @WalterMuskovic]

Living with an #AutoimmuneDisease or know someone who is?
Check out @hydra_hamster'stwitter presentation today at 2:45 as part of #SVCRS2021 and check out the autoimmune community survey
https://t.co/9XFFSTsTx3
#Spoonie #ChronicIllness #Autoimmune

[Walter Muskovic @WalterMuskovic]

Interested in lncRNAs? Check out our new paper up on bioRxiv where @MK_CCI and I use high temporal resolution RNA-seq time series data to demonstrate both human and mouse lncRNAs mirror the expression of nearby protein-coding genes https://t.co/Od8EYrtXlN

[Alicia Oshlack @AliciaOshlack]

We are recruiting group leaders! Come and join me and set up your own research group at @PeterMacRes