Welburn Lab

We study the vast roles of kinesin motors during mitosis using a variety of approaches ranging from structural biology to single molecule imaging!

[Welburn Lab @WelburnLab]

Check out our latest work in @JCellBiol characterising the roles of Kif18b in spindle positioning and microtubule depolymerisation! https://t.co/O6K38W11pL

[Ben Craske @bcraske]

Very happy to see our CENP-E review published today in #Essaysinbiochemistry ! @dynamicMT @PPPublishing "Leaving no-one behind: how CENP-E facilitates chromosome alignment" https://t.co/5YVKWOyfIm

[Welburn Lab @WelburnLab]

If you missed it last week, check out our latest preprint on how CENP-E is recruited to kinetochores by BubR1 which is posted on @biorxivpreprint! https://t.co/zTvcUbXgy6

[Welburn Lab @WelburnLab]

Finally, #JournalClub how the structural state of microtubules facilitate preferential localisation of EB1 to the growing tips
https://t.co/IeK1W4Vgn4

[Welburn Lab @WelburnLab]

#JournalClub Stabilisation of end-on attachments by delivery of PP1 to the kinetochore by Astrin's C-terminal RVxF motif!
https://t.co/UNi8AZa6me

[Welburn Lab @WelburnLab]

#JournalClub insights into Kip3 mechanism of microtubule depolymerisation
https://t.co/Z8OGDzpoMV

[Welburn Lab @WelburnLab]

and also....
https://t.co/O0GNfvx7Lx

[Welburn Lab @WelburnLab]

The key theme of our #JournalClub today appeared to be reconstitution of microtubule branching with Augmin, TPX2 and the gamma-TuRC
https://t.co/qQCnSMBrLe…

[Welburn Lab @WelburnLab]

https://t.co/XHmeGCSf8U

[Welburn Lab @WelburnLab]

#JournalClub Comparing the kinetics and microtubule interactions between chromokinesin Kid and Drosophila NOD
Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions To Perform a Similar Function https://t.co/bRVWNwXH6q

[Welburn Lab @WelburnLab]

#JournalClub And finally, a really cool preprint using a dual colour FIONA tracking system to track the stepping of KLP11 and KLP20 heteromeric motors! https://t.co/JcBldTJt7t

[Welburn Lab @WelburnLab]

#JournalClub Predicting the outcomes and precision of CRISPR depends on target site sequence https://t.co/MHa1lg01xn

[Welburn Lab @WelburnLab]

#JournalClub preprint demonstrating meiosis specific roles for kinesins Cin8 and Kip3 in cohesin removal https://t.co/Vx6g5kKo0q

[Welburn Lab @WelburnLab]

#JournalClub Structural insights into how tubulin is detyrosinated by Vasohibins
https://t.co/8lfkhj1NUT

[Welburn Lab @WelburnLab]

#JournalClub from last week - starting with one of many Lis1-Dynein preprints! Lis1 promotes the formation of maximally activated cytoplasmic dynein-1 complexes https://t.co/5bqqqRGfqm

[Welburn Lab @WelburnLab]

#JournalClub Sticking with structural biology, a really cool cryo-em paper on the activation of the NLRP3 inflammasome.. https://t.co/1V1ym3dsUp

[Welburn Lab @WelburnLab]

#JournalClub A structural study shows that microtubule capping proteins which block two protofilaments at the microtubule plus end can inhibit nucleation. https://t.co/iF2xdnHnnO

[Welburn Lab @WelburnLab]

#JournalClub An interesting study demonstrating that introduction of Kinesin-13 specific residues to the Kinesin-1 motor enables it to recognise the microtubule end. https://t.co/r3cBEkRcAZ

[Welburn Lab @WelburnLab]

#JournalClub Zeeshan et. al. show a role for the Plasmodium microtubule depolymerase, Kinesin-8X, in oocyst development during parasite proliferation and transmission. https://t.co/LEKEw7BWVp

[Welburn Lab @WelburnLab]

#JournalClub Using FRET to show that Ndc80 fluctuations between straight and bent conformations impact its ability to bind to microtubules.. https://t.co/kDA0yDzo3a

[Welburn Lab @WelburnLab]

#JournalClub Some beautiful imaging of branching microtubule nucleation via augmin in dividing Drosophila cells.. https://t.co/RkuZZ95Aiy