Tyler Wish

CEO StillMind Therapeutics

[Tyler Wish @WishTyler]

Magic shotguns vs. bullets — Roth et al., 2004

[Robert Y. Chen @therealRYC]

🚨 Exome-sequencing 470,000 people found a grand total of 0 genes linked to risk of developing an affective disorder that required seeing a psychiatrist.

Rare variants with large effect-size don't cause depression or anxiety.

[Tyler Wish @WishTyler]

Fascinating work on ReHo deficits and hypoperfusion in depression. At Stillmind, our SM-001 program targeting elevated ET-1 GPCR signaling in bipolar disorder addresses related neurovascular mechanisms, highlighting the potential of #precisionneuroscience in mood disorders

[JAMA Psychiatry @JAMAPsych]

Including an inflammation specifier for major depression in the DSM-6 could improve diagnosis, treatment, and research by identifying patients with specific inflammatory biomarkers and depressive symptoms. https://t.co/kXen9Pnnyd

[allen institute @AllenInstitute]

Advances in neuroscience have yielded massive, rich datasets from various analysis techniques and modalities. In a @NatureNeuro perspective, researchers underscore the importance of an integrative approach to render a more complete picture of the brain. https://t.co/RxKI85bD6J

[Robert Y. Chen @therealRYC]

https://t.co/emwDTng3MR

[Bruce Booth @LifeSciVC]

What a journey for Intracellular Therapies Inc ($ITCI) - acquired yesterday at the ripe age of 23 yrs old.

Series A of $2.9M in 2002. Moshe Alafi, called one of the founders of biotech (whose VC firm backed Cetus, Amgen, ABI, others) was the lead of the A-round. Over next decade, the startup raised less than $40M in private capital across at least four rounds - a model of capital efficiency.

As the markets opened in 2013, ITCI reverse merged with a public shell company (mining company Oneida Resources Corp) and began trading late that year.

It already had its gem in hand: in 2013, lumateperone (Caplyta) was in Phase 2 for schizophrenia.

They raised $60M in the PIPE (led by Deerfield), and $120M in a secondary in 2014. This was enough to keep things going for another 8 years. They didn’t raise again until 2022… Wow…

As late stage development costs mounted, on the back of exciting data they raised $460M in 2022... and then again in 2024, $500M…

All-in, ITCI raised $1.2B from investors, private and public. Sold to J&J for nearly $15B.

ICTI was trading at $10 at end of 2013. Bought for $132. Over a 13x in less than 12 years.

An impressive value-creation story over 23 years. And one whose history most of us don't know much about.

[John Ruffolo @ruffoloj]

It’s time to call an election in Canadá so the people can decide the future economic direction.Spending is out of control.Deficit guardrails grossly breached.Debt doubled in 10 years.Taxes are up.Unemployment is up.Interest rates will have to decrease and so plan for a $1.50 USD.

[Harley Finkelstein @harleyf]

@chamath Heart breaking for 🇨🇦

[Nature Reviews Drug Discovery @NatRevDrugDisc]

FDA approves first schizophrenia drug with a new mechanism of action since the 1950s https://t.co/j5X1Jr2fCZ

Karuna/Bristol Myers Squibb’s KarXT (Cobenfy), which acts on M1/M4 muscarinic acetylcholine receptors, expands the treatment landscape beyond dopamine-targeted drugs

[Nathan Benaich @nathanbenaich]

ai in drug discovery is kinda working eyyy

[David Li @davidycli]

"If we take the success rates we observed for AI-discovered molecules in Phase I and II and assume that these hold in the future, and if we combine these with historic Phase III success rates, a striking picture emerges:

the probability of a molecule succeeding across all clinical phases end-to-end would increase from 5–10% to ∼9–18%."

^^^ this is just the very beginning

https://t.co/cWLq5n7TX1

[Eric Topol @EricTopol]

People with 2 copies of APOE4 were known to have a high risk of #Alzheimers.
Today that changed to nearly 100% full penetrance
@NatureMed
https://t.co/2JA7KcpmLC

[Stillmind Therapeutics @StillmindTx]

Today, on #WorldBipolarDay, we stand in solidarity with those living with bipolar disorder. At StillMind Tx, our commitment to pioneering precise medicines for bipolar disorder is unwavering. Let's continue to advocate for understanding, support, and groundbreaking treatments

[NEJM @NEJM]

Original Article: Risk of Autism after Prenatal Topiramate, Valproate, or Lamotrigine Exposure https://t.co/hZY91DqETV

Editorial: Risks of Fetal Exposure to Topiramate https://t.co/OUzjNXTzs7

#Pediatrics

[STAT @statnews]

The biotech industry has finally brought a spate of promising new psychiatric treatments to the table. https://t.co/bo3sRv5Uyz

[Tucker Carlson @TuckerCarlson]

Ep. 68 Whatever happened to the truckers who dared to protest Justin Trudeau? Some of them are still in jail, years later. Trucker Gord Magill explains how darkness has descended on Canada.

[Tyler Wish @WishTyler]

This investment is a testament to the pivotal role Actua and the Federal Government play in shaping our STEM ecosystem. Congratulations to Jen and the entire Actua team for their relentless dedication and impact. Looking forward to the continued growth of our future innovators!

[Actua @ActuaCanada]

Actua is thrilled to be announced as a recipient of the Government of Canada’s Strategic Science Fund and looks forward to continuing to scale and deepen our work to build a more inclusive and diverse #STEM ecosystem. https://t.co/3qoAvAy6IL

[Tyler Wish @WishTyler]

Couldn't agree more with @SwilersRugby! Dr. Pat Parfrey has been a beacon for young athletes, elevated Canada on the world rugby stage, and made invaluable contributions to healthcare and policy in Newfoundland. A true multi-faceted hero. #OrderOfNL

[Swilers Rugby Club @swilersrugby]

Congratulations to our very own Dr. Pat Parfrey on his well deserved induction into the order of Newfoundland and Labrador yesterday!

[tobi lutke @tobi]

It’s tragic what’s happening with with Canadian regulation in this space. It’s probably well meaning, but extremely bad. Push back and let’s focus on building Housing, companies, infrastructure, wealth, and trust. This does none of that.

[@jason @Jason]

this is the best talk I've ever seen at a conference

@bgurley 🐐

[Patrick Dexter @patrickdextervc]

Northwest Passage by the great Canadian songwriter Stan Rogers (1949 – 1983). From the across the Atlantic on the west coast of Ireland, Happy Canada Day! 🇨🇦