Zoe S

Smiling as much as I can,coz it's priceless

[Umut A. Gurkan @UAGurkan]

Our new publication in @RoySocChem @LabonaChip Journal introduces the OcclusionChip, a clinical microfluidic platform designed to replicate sickle cell disease-associated microvascular occlusions under chemically induced hypoxia. The study systematically evaluates the efficacy of anti-sickling therapies, demonstrating significant reductions in red cell mediated occlusions, thus advancing the development and testing of targeted therapeutic strategies in the lab.
👉 Access the open access full paper: https://t.co/9oWv9P2qHo
#SickleCellDisease #Microfluidics #BiomedicalResearch #LabOnAChip #Hematology #MedicalInnovation #PrecisionMedicine

[Blood Journals Portfolio @BloodPortfolio]

Voxelotor, GBT021601, PKR activator lower [Ca2+]total by inhibiting Piezo1 and modifying clearance pathways, improving RBC deformability. https://t.co/6J85DM03Gh #sicklecelldisease #SCD @ConquerSCD

[Zoe S @ZoeSekyonda]

@MakBME @cwru @IEEEembs @HeriotWattUni @brian_k_matovu @rkalyes1 @RAEngNews @KertheeKate @sseki_biomed_en @pctechmagazine @DukeU @thedukeofkigezi Thank for hosting, such an honor. More is yet to come

[Makerere University Biomedical Engineering @MakBME]

Honored to host Dr. @ZoeSekyonda , a trailblazing Ugandan biomedical engineer & PhD candidate at @cwru ! 🇺🇬🧬 She shared her groundbreaking research on portable #microfluidic diagnostic tools for anemia & sickle cell disease, transforming blood testing in low-resource settings.

[Umut A. Gurkan @UAGurkan]

American Society of Hematology @ASH_hematology #ASH2024 Annual Meeting is fast approaching, here are some of the new research we will present this year:

📌 1094 A New Diagnostic Method for Premarital Screening of Thalassemia and Hemoglobinopathies: Microchip Electrophoresis (Gazelle) Method
https://t.co/jR5LUiyWEg

📌 2216 Proposed Use of the Microfluidic Impedance Red Cell Assay (MIRCA) to Identify Individuals with Sickle Cell Disease in Need of Second Line Therapies
https://t.co/ci7B7Lruft

📌 3873 The Intracellular Effects of Anti-Polymerizing RNA Aptamers in Sickled Red Blood Cells
https://t.co/koktqEvpQd

📌 1101 Voxelotor and Red Blood Cell Pyruvate Kinase Activator Enhance Sickle Erythrocyte Deformability By Calcium Efflux
https://t.co/Ged9R65oDC

📌Scientific Workshop on Challenges and Novel Technologies in Red Blood Cell Quality Assessment
🗓️📍Time and Location: Friday, December 6, 2024: 2:00 PM-5:00 PM, Room 3 (San Diego Convention Center)
https://t.co/96PbUsdxyc

@cwru @CaseEngineer @CWRUBME @CWRUSOM

[Zoe S @ZoeSekyonda]

@IlahaIsali @AmerUrological @WCMUrology Congratulations @IlahaIsali

[Umut A. Gurkan @UAGurkan]

Happy to share that @ZoeSekyonda's recent paper was selected as front cover in @analystrsc.

In this article, we present a rapid hemoglobin-oxygen dissociation measurement approach to screen for and detect hemoglobin-oxygen affinity abnormalities and to evaluate the function and efficacy of hemoglobin modifying therapies within minutes.
@cwru @CaseEngineer @CWRUBME

Cover art illustration credit: Grace Gongaware

Read the full open access article here:
https://t.co/wWVWiieW9Y

[Umut A. Gurkan @UAGurkan]

I am happy to share a new open-access article from our lab, just published in @analystrsc: "Rapid measurement of hemoglobin-oxygen dissociation by leveraging Bohr effect and Soret band bathochromic shift"

‼️ Despite its vital role in human physiology, hemoglobin-oxygen dissociation measurement is underutilized in basic research and in clinical laboratories, primarily due to the technical complexity and limited throughput of existing methods.

👉 We present a rapid hemoglobin-oxygen dissociation measurement approach to screen for and detect hemoglobin-oxygen affinity abnormalities and to evaluate the function and efficacy of hemoglobin-modifying therapies within minutes.

👉 We anticipate this method's broad adoption will democratize the diagnosis and prognosis of hemoglobin disorders, such as #sicklecelldisease.

👉 This method has the potential to transform the research and development of new targeted and genome-editing-based therapies that aim to modify or improve hemoglobin-oxygen affinity.

Kudos to @ZoeSekyonda, PhD candidate in our lab, who has led this highly complex and challenging project for many years. @CWRUBME @CaseEngineer @cwru

Initial successful validation of the technology was achieved at @cwru and @UHhospitals in Cleveland, Ohio, and at @JcrcUganda in Kampala, Uganda, where Zoe is from.

I would like to thank @nih_nhlbi @NIBIBgov and @ASH_hematology for supporting Zoe and this project.

Link to full article:
https://t.co/wWVWiieW9Y

[Zoe S @ZoeSekyonda]

@IlahaIsali @LauraBukavinaMD Congratulations @IlahaIsali

[CWRU Engineering @CaseEngineer]

.@CWRUBME PhD student, Zoe Sekyonda, has been selected as RADx Tech DIVE fellow. @NIBIBgov

Sekyonda's device rapidly measures oxygen levels in blood samples and through this fellowship, she will learn how to create a business model to attract investors. https://t.co/eyAkK3jse9

[Zoe S @ZoeSekyonda]

@WCMUrology @WeillCornell @nyphospital @AmerUrological @RodriguezMDUrol @UroResidency @UrologyMatch @UroAcademic Congratulations @IlahaIsali. Well deserved. Happy for you

[Umut A. Gurkan @UAGurkan]

Congratulations to @ZoeSekyonda, PhD candidate in our lab for being a part of this prestigious @NIBIBgov
fellowship! @CWRUBME @CaseEngineer @cwru

A new RADx® Tech fellowship helps underrepresented innovators advance their technology
👇
https://t.co/QUEyWd6USU

[Umut A. Gurkan @UAGurkan]

The best part of @ASH_hematology #ASH23 is having fun and discussing science with collaborators, past and current member of the lab. @drtolutolu @RanAnPhD @ZoeSekyonda @SolomonOshaba

[Zoe S @ZoeSekyonda]

@UAGurkan @ASH_hematology @CaseEngineer @CWRUBME Thanks you @UAGurkan for your unwavering support and mentorship

[Umut A. Gurkan @UAGurkan]

Congratulations and #ASHKudos to @ZoeSekyonda for winning @ASH_hematology Graduate Hematology Award and Fellowship. @CaseEngineer @CWRUBME

[Umut A. Gurkan @UAGurkan]

Wonderful to get together with our lab’s current and past members at @ASH_hematology #ASH23 in San Diego. #ASHKudos to them for presenting their wonderful work here. @SolomonOshaba @ZoeSekyonda (New ASH graduate fellow) @RanAnPhD (@UHouston), Chloe Turpin. @CWRUBME @CaseEngineer

[Umut A. Gurkan @UAGurkan]

Premier event in #hematology🩸is approaching fast, @ASH_hematology #ASH23. We have exciting new research to share for the 1st time: 1/6: Novel RBC Adhesion and Deformability Assays Reveal Deleterious Effect of Diabetes on RBC Health. @CaseEngineer @cwru 👇 https://t.co/8YP68UyMJR

[Zoe S @ZoeSekyonda]

@aimbe It was a privilege and an honor to part of this year public policy institute . Thank you @aimbe for hosting and for the travel award. Thank you @UAGurkan, @CaseEngineer, @CWRUBME

[AIMBE @aimbe]

Thank you to all of the students who participated in the AIMBE Public Policy Institute! A perfect ending to a 2-day science policy workshop with a U.S. Capitol tour.

[CWRU Biomedical Engineering @CWRUBME]

#CWRU biomedical engineering student Zoe Sekyonda received the American Society of Hematology's 2023 Graduate Hematology Award.

A warm congratulations to Zoe for this impressive achievement!
https://t.co/rQW4nyxeE7