Sameed M

Pulmonary & Critical Care @ClevelandClinic. #FOAMed. 🏴󠁧󠁢󠁳󠁣󠁴󠁿🇵🇰🇺🇸Tweets reflect my personal opinion. Director ILD clinic @JeffHealthEH @WeAreJefferson

[Sameed M @_MSAMEED]

Highly recommend attending this session; it was pivotal to help my find guidance and advice for own journey

[Alice Gallo, MD @GallodeMoraesMD]

Today at 3pm at The Learning Studio in the Networking Super Center, join us for a session targeted towards transitions in training for IMGs
@atscommunity @atsearlycareer
#ats2026

[ATS Early Career @atsearlycareer]

Join us in the Learning Studio Wednesday, May 20, at 11AM located at the Networking Super Center (NSC) for our session "Reliable Lung Sounds: Practical AI at the Point of Care".

Add to your itinerary now: https://t.co/XLBNKdwrEy

[Sameed M @_MSAMEED]

Daily SBTs are stand in patients undergoing mechanical ventilation but are there any true minimal ventilator settings for SBT? What do you use
@ZonairKhanMD @Narpaul94 @jamilmshahi @emireles_c @GallodeMoraesMD
Source:
DOI: 10.1056/NEJMoa2209041
DOI: 10.4187/respcare.10642

[Sameed M @_MSAMEED]

@SiaFoundation Big fan of the Sia Project; and this would be perfect for my personal projects, research and discovery journal

[Sameed M @_MSAMEED]

While it is a breath of fresh air to see more vaccine research, for full transparency both these studies in @JAMAPediatrics are simulation, not empirical data from a natural experiment or randomized trial. The model’s conclusions are only as valid as its assumptions. The authors used a “simulated US birth cohort,” meaning all estimates are probabilistic projections, not measured outcomes.

[Sameed M @_MSAMEED]

One of my favorite things to teach in MICU is how to ventilate a patient with asthma. some very basic changes can set your patient for success; let me know what else would you do @emireles_c @Thind888 @IM_Crit_ @jamilmshahi @RobChatburn @chatterJ5 @respresource

[Sameed M @_MSAMEED]

Vaccine prevents shingles that’s an established fact but based on the quoted study it is a little over reach to claim a vaccine “slows aging” from cross-sectional survey data.
Major red flags: they dropped the adaptive immunity domain when it showed vaccine harm; inflammation supposedly improved years later (biologically backwards timing); and neurodegeneration/CV biomarkers were null—undermining their unified “aging” theory. This is association, not mechanism. Healthy-user bias likely explains the entire signal.

A more conclusive study is needed to prove actual effect

[Sameed M @_MSAMEED]

Thank you, your attached article is an excellent read

It is a brilliant deconstruction of one of critical care’s most persistent conceptual tangles. The key insight — that CCP is a conditional binary collapse threshold, not a continuous opposing pressure — resolves contradictions that have frustrated clinicians for decades.

The distinction between active arteriolar closure and passive Starling-resistor behaviour is the crucial move. Applying the vascular waterfall metaphor to arterioles was always a category error. Arterioles snap shut through active smooth-muscle tension — they don’t narrow gradually like a collapsible vein.

The SVR point has direct practical consequences. When collapsed beds drop out of the parallel network, calculated SVR becomes a mathematical artefact of the surviving open pathways — not a true reflection of vasomotor tone. Escalating vasopressors to chase an SVR target in that setting may worsen the very problem you’re trying to fix.

The kidney deserves special mention: Gerota’s fascia means it is uniquely vulnerable to two simultaneous CCP-elevating forces — catecholamine-driven afferent constriction and interstitial oedema causing capsular amplification. This directly explains the U-shaped renal response to norepinephrine.

The most pressing next step is validation of accessible bedside tools — renal resistive index, peripheral perfusion indices, sublingual microcirculatory imaging — that can actually operationalise the Interface 2 concept in real time.

The practical bottom line is simple: when the monitors and the tissues disagree, trust the tissues. CCP finally makes sense when used for what it was always meant to do — identifying when and where flow continuity has been lost, so that therapy can restore it rather than simply chase a pressure number

[Sameed M @_MSAMEED]

The Critical waterfall concept of Perfusion in Shock
Source: https://t.co/puct6jqHYP
@ZonairKhanMD @jamilmshahi @Narpaul94

[Sameed M @_MSAMEED]

The classic Lassie Challenge in the MICU, a must know for everyone when dealing with AKI. @ZonairKhanMD @Narpaul94

[Sameed M @_MSAMEED]

@kojiprecedex @Pocus101 @ZonairKhanMD @Narpaul94 @msiuba Sure here you go

https://t.co/EECkbpsviM

[Sameed M @_MSAMEED]

Diastology Basics in the ICU. @Pocus101 @ZonairKhanMD @Narpaul94 @msiuba

[Sameed M @_MSAMEED]

How to assess PA-RV coupling with echo; Grade I - IV
Source: https://t.co/Sj1Jn1CV7T

[Sameed M @_MSAMEED]

@williamkellymd Condition: autoimmune Pulmonary Alverolar proteinosis

CT pattern: Crazy Paving

Rx: Whole Lung Lavage or inhaled rhGM-CSF

[Sameed M @_MSAMEED]

My approach to cough management in ILD

[Hany Ragy @Hragy]

You pay annual fees, which give you some benefits that include journal access, and congress reduced attendance fee.
But patients in many countries are led to believe that it was those famous societies that approached the doctors and chose them because of their brilliance, not tru

[Hany Ragy @Hragy]

It is important to know that many medical societies charge exorbitant amount of money to give you titles like FACC , FESC , SCAI etc, you apply,if your credentials are approved you get ok’d then you have to pay a hefty annual fee, you are not nominated or selected, you apply& pay

[Sameed M @_MSAMEED]

@hubermanlab Phosphortech full spectrum sunlight bulb (no affiliation)

https://t.co/GPUarSqSn3

[Sameed M @_MSAMEED]

I first write a detail query in Perplexity Search using my preferred AI model, let’s say Claude Opus, with thinking; I can also click additional search options like academia (which includes PubMed etc) and Social to see any anecdotal conversations involved in the background research

Now once the reply is back, perplexity actually quotes sources for each of its statement. I click the sources tab and copy off the ones relevant to me and export them to notebookLLM

NoteLLM then can create my desire output (Infograph’s, pathway, figures, slides)

Back to Perppexiry I add the sources to my Space (a localized search machine), so perplexity creates/replies using only the space sources and I switch to perplexity Computer

We commanded to create a resource library with google like search that reruns the search every Monday for new literature being published on this topic and add it to space that we can search for later

[Sameed M @_MSAMEED]

@perplexity_ai +@NotebookLM is fire. Amazing synergy

[Sameed M @_MSAMEED]

So my job as an academic is to make academic content lets a small lecture for slides or background research for grant

We are investing a therapy let’s name it X for countering Fatigue in Sarcoidosis and current in the grant writing phase

In academia we need less hallucination more accuracy…..