Trace Henry

Med Affairs @AdaptiveBiotech | Occasional thoughts | UMich PhD @UM_MNI

[Trace Henry @_Trace_Henry]

@shelbynewsad "immune profiling tests showing all diseases you’ve been exposed to" --> love this one

[Trace Henry @_Trace_Henry]

@andrewpannu Really interesting analysis, but anito-cel not on market yet. Abecma (BMS/Bluebird) likely the better comparator in the BCMA CAR-T space

[Trace Henry @_Trace_Henry]

@hannu @threadreaderapp unroll

[Trace Henry @_Trace_Henry]

@hardimanjames @ronalfa @UnlearnAI Discovery/Pre-clinical I get, but what's the angle where ML has outsized impact in Ph3 specifically? Better pairing of unique patients groups w/ ever more narrowly defined targeted compounds? Synthetic control arms?

[Trace Henry @_Trace_Henry]

@subatomicdoc @rweichselbaum @MichaelTMilano @fumikochino @TheLizArmy @cd_fuller @IshwariaMD @maryam_lustberg @DavidSteensma @achoud72 @adamhayden I thought this was a good relatively recent overview of how the philosophers seem to be thinking about things https://t.co/I6F6XZU0X2

[Trace Henry @_Trace_Henry]

@gottapatchemall Really enjoying this genuary series. Hope you keep it up.

[Trace Henry @_Trace_Henry]

@SaKrabbe @DZNE_en Congrats Sabine! Well deserved.

[Adi Shavit @AdiShavit]

Mathematician and genius John Conway, inventor of The Game of Life has succumbed to COVID-19 today. What a terrible loss for the world. RIP.

[Addgene @Addgene]

New modular ion channels and selective, sub-nanomolar potency agonists (uPSEMs) were developed from Scott Sternson's lab @HHMIJanelia. This system is effective in the brain of rodent and primate models. #chemogenetics https://t.co/hVwLzHxzFu

[Huisken lab @huiskenlab]

In collab. w/ @OICE_Imaging we present an animated transformation of a growing #zebrafish nervous system via 3Dscript, imaged on a custom-built #lightsheet microscope. While the time-lapse progresses, the image volume is spatially transformed. Read more: https://t.co/oir6hQZQ16

[Trace Henry @_Trace_Henry]

@YttriLab @CMU_Bio Heeeeeeeyyyyy congrats!

[Trace Henry @_Trace_Henry]

10,000 compound, multibehavioral zebrafish screen to ID neuroactive drugs w/ appetite modulating effect. With validation in mice! https://t.co/DDrCKiffWd

[Trace Henry @_Trace_Henry]

@YttriLab Hey now, a triple bypass before 50 is a small price to pay for having a six pack. Plus I heard that you can achieve 100% cerebral capacity once your brain starts processing ketones

[Victor Corces @CorcesVictor]

Our new perspective suggesting that 3D chromatin organization is an emergent property of chromatin-bound proteins was just published https://t.co/KLOImQlzJu

[Eric Schreiter @ERSchreiter]

Our paper describing improved CaMPARI variants for marking neuronal activity is out: https://t.co/CcbHKXhumK
We also describe an antibody that is selective for the photo converted (red) form. Reagents are available, let us know how we can help!

[Ran Blekhman @blekhman]

Say you pick 100 random bioinformatics software tools -- how many will you actually be able to access, install, and run?

Our new paper: https://t.co/rllGmGdL1s

[Sabine Krabbe @SaKrabbe]

Our preprint describing how adaptive disinhibitory gating by VIP interneurons supports associative learning is now online: https://t.co/X4I5jVfItr @FMIscience @imed_tweets

[David Margolis @MargolisLab]

'a library of 230 AAVs. ~11% target expression to neuronal + glial cell types in mouse retina, mouse brain, non-human primate retina in vivo, and in human retina in vitro... recording, stimulation, characterization, intersectional labeling of cell types' https://t.co/azYOCp8UNV

[Carsen Stringer @[email protected] @computingnature]

Thread: A picture is worth a thousand words, and your brain needs billions of neurons to process it. Why do we need so many neurons? To find out, we recorded thousands of them in mouse visual cortex. Here’s some data, and a link to the paper:
https://t.co/XsrxRsLzS1

[Davi Bock @dddavi]

And, a preview of what the whole fly brain EM dataset's user community has been up to while we rewrote, etc. ~5 mm traced cable length shown here!
beautiful visualization by @uni_matrix, somewhat mangled by my downsizing & trimming to only 180° rotation
#ASAPbio #bioRxiv