Today marks a historic milestone for the type 1 diabetes (T1D) community: the @US_FDA has approved Tzield for use in individuals ages 8–17 with stage 3 T1D. This is the first disease-modifying therapy ever approved for stage 3 T1D!
Tzield preserves beta cell function in newly diagnosed individuals, which has been shown to result in fewer hypoglycemic events, lower insulin use, reduced burden of care, and improved A1c. We'll keep working to ensure people with stage 3 T1D everywhere, not just in the U.S., have access to therapies that help them live healthier lives.
Breakthrough T1D and the T1D Fund have supported the development of this therapy for over 30 years, and we're grateful to the FDA for recognizing the urgent unmet need in T1D and expediting Tzield's approval through the accelerated approval pathway. We also thank @sanofi for their continued research and the T1D community for advocating for therapies that change the course of this disease. Read more here: https://t.co/OaU1VQV1cZ
oh you don't believe in the acceleration of biology?
ask yourself why:
- Moderna and Merck's personalized mRNA cancer vaccine just cut melanoma recurrence by 49% over 5 years. presented at ASCO 2026 this week. the same mRNA tech from COVID is now fighting cancer
- CAR-T therapy used to take weeks in a specialized lab. in vivo CAR-T is now a single injection. off the shelf. moving into autoimmune disease and cardiac fibrosis
- Ginkgo Bioworks' Nebula is the world's largest autonomous lab. running 36,000 reactions and generating 150,000 data points per loop. 24 hours a day. no human required. Amazon plugged them in as the wet lab backbone for their Bio Discovery platform
- Isomorphic Labs raised $2.1B to design drugs with AI. the lab is becoming software
- the first reverse-aging drug was injected into a human this week. Life Biosciences. David Sinclair is bullish
this is june 2026
and as if thats not enough, we have the Superhuman Fund II actively backing the infrastructure that makes all of this possible at scale
if you are building in this space, let's talk
bio/acc
This tool was proposed 15 years ago and considered nearly impossible to build.
Today, the laser phase plate can now image the majority of human proteins that cryo-EM couldn’t touch.
Every one of those proteins is a potential drug target.
In a series of 3 papers and preprints, we’re thrilled to share with you the working laser phase plate. In collaboration with research led by Holger Müller at UC Berkeley, this is a huge innovation in imaging to make small and faint objects inside cells visible. https://t.co/trnQhI6OJr
“Because we believe the best operating systems aren’t just built on big breakthroughs. They’re built on sweating the details” - WWDC 2026
Is it too much to hope Steve Job’s philosophy is coming back to Apple?
First time applying to YC with @Adam_Biotech. Got rejected, but being in the top 10% means we’re on the right track.
Proof you should be building based on a pain point YOU have experienced yourself.
We’ll be back for Fall @ycombinator!
SO excited to continue building @Adam_Biotech at Offseason II @fdotinc this summer.
Getting to go back to obsessively building in SF after a year in Seattle is going to be amazing.