@MolBioMike@biocheMichael For me Bioemu have never worked… compares to my own MD simulations which is indeed my field, really weird and for sure never visites conformations were generared tih Bioemu
What if AI could invent enzymes that nature hasn’t seen? 👩🔬🧑🔬
Introducing 🪩 DISCO: Diffusion for Sequence-structure CO-design
14 rounds of directed evolution and over a year of wet lab work. That's what it took to engineer an enzyme for selective C(sp³)–H insertion, one of the most challenging transformations in organic chemistry.
DISCO surpasses this with a single plate. No pre-specified catalytic residues, no template, no theozyme, no inverse folding, just joint diffusion over protein sequence and structure.
📝 Blog: https://t.co/j9Za0JigfO
📄 Paper: https://t.co/ficrYNBBrM
💻 Code: https://t.co/p81sSwoaPH