abarralw

Postdoc at @pioneerfactors , studying H3K9me3-heterochromatin and pioneer factors

[abarralw @abarralw]

📢Check out our last review on #pioneerfactors in @TrendsGenetics https://t.co/sbkdUxAyJO

[abarralw @abarralw]

@Yaiza_Nunez_Alv Congratulations! Felicidades! 🥳

[Trends in Genetics @TrendsGenetics]

The February issue is live! Multimodal single-cell CRISPR screens, pioneer factors, and transcriptional bursting are just some of the hot topics covered. Check it out!
https://t.co/iAVkkzaV5c
Thanks to Amandine Barral from the Zaret lab (@pioneerfactors) for the cover image!

[abarralw @abarralw]

@dagarfield @TrendsGenetics I would say yes. For example, overexpression of the pioneer factor Sox2 in human fibroblast leads to cell reprogramming. This has also been validated for many other pioneer factors in different cell contexts.

[abarralw @abarralw]

📢Check out our last review on #pioneerfactors in @TrendsGenetics https://t.co/sbkdUxAyJO

[Carmelo Ferrai @CarmeloFerrai]

Pioneer factors: roles and their regulation in development ⁦@abarralw⁩ ⁦@pioneerfactors⁩ https://t.co/xiCPo8Y9sF

[Trends in Genetics @TrendsGenetics]

Pioneer factors: roles and their regulation in development https://t.co/3r2EB2clXJ

[Nature Reviews Genetics @NatureRevGenet]

Pioneer factors — key regulators of chromatin and gene expression https://t.co/xOSqnzbq1L #Viewpoint by Martha L. Bulyk, Jacques Drouin, Melissa M. Harrison (@harrisonflylab), Jussi Taipale & Ken Zaret (@pioneerfactors)

[abarralw @abarralw]

Our review 'The chromatin signatures of enhancers and their dynamic regulation' is now out! https://t.co/QmDW3VFn3S

[abarralw @abarralw]

@serialChIPer @ChrisGinestier @Emmachadtem @AgenceRecherche Congratulations!!!!! 🥳🥳🥳 So happy for you !

[InstituteHumGenetics @IGH_MTP]

@IGH_MTP @CNRS_OccitaniE @umontpellier Mockly et al. show that the miR-34a microRNA is not a tumor suppressor (as assumed for the last 14 years) and therefore resolve several long-standing inconsistencies.
https://t.co/0pvVcSE2sJ

[Cell Reports @CellReports]

Histone marks regulate the epithelial-to-mesenchymal transition via alternative splicing https://t.co/gxgMZaH9CZ

[Molecular Cell @MolecularCell]

SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers https://t.co/7KKrOOvBrD

[Yaiza Núñez @Yaiza_Nunez_Alv]

So happy to see out our latest work!!! An amazing intra and inter lab collaboration to show that locus specific epigenetic dCas9 induced histone modification changes are sufficient to change alternative splicing and change cell phenotype! @IGH_MTP

[ESC & iPSC News @ESC_iPSC_News]

🔎 Montpellier University (@IGH_MTP) researchers characterized the function of an atypical heterochromatin, providing mechanistic insights into its involvement in the maintenance of #cellidentity.

#OpenAccess: 🔓 https://t.co/zxin0fwXty

[Molecular Cell @MolecularCell]

Online Now: SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers https://t.co/Z7L9pTa8Yw

[abarralw @abarralw]

@lab_hat @MolecularCell Thank you Jacques !

[abarralw @abarralw]

Excited to share our paper : 'SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers' is now out in @MolecularCell
https://t.co/lmldpgnYOB

[abarralw @abarralw]

@i_jerko @MolecularCell Thank you Ivana !!!

[abarralw @abarralw]

@david_lleres @MolecularCell Thank you David!

[abarralw @abarralw]

In differentiated tissues, a subset
of these dual domains is destabilized and becomes enriched in active #enhancer marks

[abarralw @abarralw]

Upon SETDB1 removal, dual domains lose both marks. They gain active #enhancer histone marks, #H3K27ac and #H3K4me1, and gain #3D contact with upregulated genes

[abarralw @abarralw]

@giacomo_cavalli @IGH_MTP It was a pleasure too!!😉