Cote lab-The KAT in the HAT

Research on chromatin linked to gene regulation and genome stability

[Cote lab-The KAT in the HAT @lab_hat]

Gairdner International Symposium on Cell Signaling in Cancer-great success and first event in our new research building. Outstanding talks and discussions, thanks to @GairdnerAwards and @AxeOnco for their support, and Emilie, Anne-Marie, Michel and Nicolas for their hard work.

[Cote lab-The KAT in the HAT @lab_hat]

Really!

[Véronique Giroux @VeroGirouxPhD]

Great tips, also apply to PIs :)

[Siavash Kurdistani @VashKurdistani]

I wrote a memoir for Michael Grunstein, a pioneer in histone biology and epigenetics, for ⁦⁦@theNASciences⁩. Read about his incredible personal journey and how his career unfolded. https://t.co/lWIAXB804x

[Claudio Alfieri @calfieri84]

I am looking for a highly motivated PhD student to join my lab @ICR_London , please help to spread the message: https://t.co/5QXVx3rkxP

[Cote lab-The KAT in the HAT @lab_hat]

@AmelieFT What is that t-shirt?

[Cote lab-The KAT in the HAT @lab_hat]

@CRC_ULaval @facmedUL

[Cote lab-The KAT in the HAT @lab_hat]

La date limite d'inscription approche, moins de 2 semaines... et c'est gratuit!
Registration deadline getting close, less than 2 weeks... and it is free!

[Cote lab-The KAT in the HAT @lab_hat]

@GairdnerAwards @crchuqc @AxeOnco

[Axe Oncologie @AxeOnco]

👀 Aperçu de la programmation 👀
Dynamiques protéiques et communications cellulaires
✏Inscription: https://t.co/JhhlXPEvew

@crchuqc @chudequebec @GairdnerAwards
#Symposium #Gairdner #Cancer #Recherche #protein

[Axe Oncologie @AxeOnco]

👀 Aperçu de la programmation 👀
Régulation par ARN codant et non-codant
✏Inscription: https://t.co/JhhlXPF344

#Symposium #Gairdner #Cancer #Recherche #ARN
@GairdnerAwards @crchuqc @chudequebec

[Cote lab-The KAT in the HAT @lab_hat]

@NogalesLab @bstask @CellCellPress @FurongLiu @zhenlinUCB Congrats! What a week for @zhenlinUCB !!!

[Cote lab-The KAT in the HAT @lab_hat]

Indeed, clearly supporting the idea that NuA4/TIP60 does not use the same molecular mechanism as SRCAP to engage nucleosomes in order to incorporate H2A.Z. The multiplicity of histone mark reader modules in NuA4 likely playing a role.

[The Nogales Lab @NogalesLab]

Please also take a look at related work by @rklouder and Carl Wu at @HopkinsMedicine diving into different functional states of the human SRCAP remodeler and a comparison with TIP60. Recently out in @biorxivpreprint
https://t.co/yPbyXNEVDK

[Cote lab-The KAT in the HAT @lab_hat]

Big intense efforts by Amel Mameri and Catherine Lachance, with strong help from @deepsud13 , @JonatHumbert , Maxime Galloy @AmelieFT and Jean-Philippe Lambert. @universitelaval @crchuqc @AxeOnco @CRC_ULaval @PROTEOQc

[Cote lab-The KAT in the HAT @lab_hat]

So happy this is finally out. Fantastic collaboration with @NogalesLab to obtain high resolution structure of the human NuA4/TIP60 complex and investigate the function of the TRRAP subunit in recruitment. https://t.co/OuyfTe5eaP

[The Nogales Lab @NogalesLab]

In humans, the essential TIP60 complex is a fusion of 2 molecular assemblies that in yeast perform different functions:
-NuA4 ➡️ a histone acetyltransferase.
-SWR1 ➡️ a chromatin remodeler that incorporates H2A.Z in promoter and enhancer-proximal nucleosomes.
🛠️🧬

[Cote lab-The KAT in the HAT @lab_hat]

https://t.co/3tZWzFk5e2

[Cote lab-The KAT in the HAT @lab_hat]

@doyonlab ours is coming out tomorrow... only TIP60, a few 3 liters preps along the way, from the cell lines from Cell Rep 2015 (https://t.co/6tVGXeqBZo)... I see that they were not able to get NCP-bound TIP60 structures either... we tried with different substrates

[Raquel Cuella Martin @raquel_cuella]

Is anyone interested in coming to work with the amazing crowd at the Cuella Martin lab and our cool projects?
An RA position will open soon, stay tuned!

[Cote lab-The KAT in the HAT @lab_hat]

@Y2K1263 @TrumanLab I feel there is a growing number of companies that now offer the service of endogenous tagging with CRISPR. Promega is one https://t.co/mIiIsXHIwN and Cyagen is another one https://t.co/ZhcOemgo9C

[Cote lab-The KAT in the HAT @lab_hat]

@cardoso_lab @TUDarmstadt @KKolobynina Congrats Dr. Ksenia!

[Cote lab-The KAT in the HAT @lab_hat]

@WhetstineLab @VAInstitute Very true!!