Adriana Puente

Cardiologa Cínica y Nuclear, CMN 20 de Nov ISSSTE. Profesor Unidad PET-CT,UNAM. Consejo SIAC Prevencion-Mujer SIAC. Capítulo Mujer ANCAM. FASNC,FSIAC, FACC,FESC

[Adriana Puente @acepuba]

@ctinocomesquita @estelais @NiteroiPref Beautiful view !

[SIAC @SIAC_cardio]

💜 Inscripción abierta
Diplomatura en Enfermedad Cardiovascular en la Mujer (2° cohorte)
📅 Abril 2026
👩‍⚕️ Dirigido a profesionales de la salud
Formación actualizada y basada en evidencia.
📩 [email protected]
#SIAC #Cardiología #CardioMujer

[Claudio Tinoco Mesquita @ctinocomesquita]

🧠 Key insight in cardiac amyloidosis imaging

Visual score (Perugini) is NOT the same between planar and SPECT.

➡️ Weak agreement (κ ≈ 0.51)
➡️ Planar imaging → higher false positives
➡️ SPECT = diagnostic standard

🚨 Only SPECT visual score should guide ATTR. @JNCjournal

[Pablo Corral MD @drpablocorral]

👉 PCSK9 & Alzheimer’s disease — lipids meet neurodegeneration

PCSK9 is moving beyond lipidology into the neurodegeneration arena.

👆 Mechanistic rationale is strong:
Degradation of neuronal LDLR, LRP1, ApoER2 → disrupted brain cholesterol handling.

👆 Downstream experimental effects:
↑ Amyloid-β accumulation
↑ Tau phosphorylation
↑ Neuroinflammation
↓ Synaptic integrity

👆 Overexpression accelerates amyloid pathology and cognitive decline (preclinical).

👆 Inhibition or genetic deletion mitigates these pathways and preserves cognition in models.
Human evidence tells a different story

👆 Some cohorts show higher PCSK9 levels in CSF and brain tissue.

👆 But large genetic and Mendelian randomization analyses:
No causal association with Alzheimer’s risk.

📍 PCSK9 inhibitors
• Powerful LDL-C reduction.
• No cognitive harm signal in trials.
• Limited blood–brain barrier penetration → effects likely indirect.

📍 Take-home
• Strong biology.
• Weak human causality.
• PCSK9 sits at the crossroads of lipid metabolism and neurodegeneration — best viewed today as a disease modifier or biomarker, not a driver.

🔗 Open Access 10.3390/life15121851

@society_eas

[SIAC @SIAC_cardio]

@SIAC_cardio desde su consejo @MujerSIAC, @AmHeartAdvocacy e @IAHFnews se unen para concientizar a la comunidad de toda América sobre las enfermedades cardiovasculares en las mujeres.

¿Sabías que 1 de cada 3 mujeres mueren por una enfermedad cardiovascular?
Hoy #VisteteDeRojo y ayúdanos a esparcir la voz!

#GoRedForWomen @goredforwomen
https://t.co/kbNdkGy1L4

[American College of Cardiology @ACCinTouch]

#cvImaging is undergoing a major transformation & this month's #CardiologyMag cover story explores the 🆕 multisociety Advanced Training Statement on Advanced Cardiovascular Imaging & its role in shaping future training pathways for evolving CV care. More: https://t.co/DzeWJr94cL

[Adriana Puente @acepuba]

@ctinocomesquita @SociedadeRio @uff_br @NiteroiPref @estelais @pabeda1 @glauciamoraeso1 Wonderfull !’

[Adriana Puente @acepuba]

@DrLopezJimenez @smexcardiologia @American_Heart Felicidades !

[SIAC @SIAC_cardio]

Si asistes al Congreso #SAC25 te esperamos en nuestro stand (núm 44)

Podrás adquirir nuestros libros
- Libro Azul
- Clínicas Interamericanas
- Cardiologia Crítica

Te esperamos!!!!
@SAC_54

[Adriana Puente @acepuba]

También disponible en versión electrónica (e-book). Adquiérelo en: https://t.co/LTtcQzLM7i o si lo prefieres versión en físico https://t.co/2c96UFzkCo @SIAC_cardio @MujerSIAC @siacprevent @ancam @adribaran @Mdelsueldo @CardioPaty

[SIAC @SIAC_cardio]

Durante el Congreso #SIACprevent2025 se presentó un nuevo libro SIAC:
“Ateroesclerosis sublínicas: el valor de un diagnóstico temprano”

Editores: Dres. Adriana Puente, Vladimir Ullauri, Mildren del Sueldo, Yoloxochitl García Jiménez, Alberto Lorenzatti y Carlos Ponte
@acepuba @vladullauri1 @Mdelsueldo @JYologarcia @ALorenzatti @DrPontecarlosi 
FELICITACIONES!!!

[SIAC @SIAC_cardio]

Durante el Congreso #SIACprevent2025 se presentó un nuevo libro SIAC:
“Ateroesclerosis sublínicas: el valor de un diagnóstico temprano”

Editores: Dres. Adriana Puente, Vladimir Ullauri, Mildren del Sueldo, Yoloxochitl García Jiménez, Alberto Lorenzatti y Carlos Ponte
@acepuba @vladullauri1 @Mdelsueldo @JYologarcia @ALorenzatti @DrPontecarlosi 
FELICITACIONES!!!

[Adriana Puente @acepuba]

@SIAC_cardio @AnaGMuneraE @Risantilopezcar @aracelilm @gonzaeperez @MujerSIAC @SIAC_MCP @ElectroSIAC1 @siacprevent @adribaran Disponible en versión e-book

[Adriana Puente @acepuba]

Felicidades a todos los colaboradores !!🙏🍀✅🌹💖

[Women As One @WomenAs1]

We’re pleased to share the 2nd edition of Women Who Lead, featuring Dr. @AnaGMuneraE, President of @SIAC_cardio.

With 20+ years in CVD & pregnancy, she champions leadership & equity across the Americas.

Read her story (6-minute read): https://t.co/gNnJAbDqYn

#WomenInCardiology

[INOCA INTERNATIONAL @InocaInternati1]

Who better to have chairing this discussion panel than one of the trailblazers in Women's Cardiovascular Health - Prof C Noel Bairey Merz!😃

A truly amazing expert panel with fantastic discussions and insight from all!

SUCH a great pleasure to host these incredible experts! 😃

[Claudio Tinoco Mesquita @ctinocomesquita]

🚀 PET/CT is rocking in cardiology guidelines!
✅ Superior to SPECT for CAD & CMD
✅ MBF/MBFR for risk stratification
✅ Stronger role in #Endocarditis, #Sarcoidosis, #Amyloidosis & transplant vasculopathy
@escardio @American_Heart
https://t.co/8wZ4CY9Pt5
@MyASNC @JNCjournal

[Adriana Puente @acepuba]

@ctinocomesquita @uff_br @estelais @sbmnuclear @BrunoLimaMDPhD @PanithayaC @nuclearsbrandao @pabeda1 @rafanuclear @MyASNC Congrats to Giovani and Davi for their excellent researchs !! And also for your mentee Claudio 🎉🎊

[Adriana Puente @acepuba]

@ctinocomesquita @aglavam @nuclearsbrandao @ap08891516 @MyASNC @almallahmo @sbmnuclear @DICSBC 👏👏👏👏

[Roxana Campisi, MD, MTSAC, MASNC @roxanacampisi]

Congratulations to Drs. Fernanda Merani, Adriana Puente, and Lucas Gutiérrez on receiving the FASNC distinction! 👏🎉 #ASNC2025 @MyASNC
@fermerani
@adrianapuente lucasgutierrez
@Ggrossman11 @ctinocomesquita

[Adriana Puente @acepuba]

@roxanacampisi @MyASNC @fermerani @adrianapuente @Ggrossman11 @ctinocomesquita Very grateful to ASNC and your own person !🙏