💜 Inscripción abierta
Diplomatura en Enfermedad Cardiovascular en la Mujer (2° cohorte)
📅 Abril 2026
👩⚕️ Dirigido a profesionales de la salud
Formación actualizada y basada en evidencia.
📩 [email protected]#SIAC#Cardiología#CardioMujer
🧠 Key insight in cardiac amyloidosis imaging
Visual score (Perugini) is NOT the same between planar and SPECT.
➡️ Weak agreement (κ ≈ 0.51)
➡️ Planar imaging → higher false positives
➡️ SPECT = diagnostic standard
🚨 Only SPECT visual score should guide ATTR. @JNCjournal
👉 PCSK9 & Alzheimer’s disease — lipids meet neurodegeneration
PCSK9 is moving beyond lipidology into the neurodegeneration arena.
👆 Mechanistic rationale is strong:
Degradation of neuronal LDLR, LRP1, ApoER2 → disrupted brain cholesterol handling.
👆 Downstream experimental effects:
↑ Amyloid-β accumulation
↑ Tau phosphorylation
↑ Neuroinflammation
↓ Synaptic integrity
👆 Overexpression accelerates amyloid pathology and cognitive decline (preclinical).
👆 Inhibition or genetic deletion mitigates these pathways and preserves cognition in models.
Human evidence tells a different story
👆 Some cohorts show higher PCSK9 levels in CSF and brain tissue.
👆 But large genetic and Mendelian randomization analyses:
No causal association with Alzheimer’s risk.
📍 PCSK9 inhibitors
• Powerful LDL-C reduction.
• No cognitive harm signal in trials.
• Limited blood–brain barrier penetration → effects likely indirect.
📍 Take-home
• Strong biology.
• Weak human causality.
• PCSK9 sits at the crossroads of lipid metabolism and neurodegeneration — best viewed today as a disease modifier or biomarker, not a driver.
🔗 Open Access 10.3390/life15121851
@society_eas
@SIAC_cardio desde su consejo @MujerSIAC, @AmHeartAdvocacy e @IAHFnews se unen para concientizar a la comunidad de toda América sobre las enfermedades cardiovasculares en las mujeres.
¿Sabías que 1 de cada 3 mujeres mueren por una enfermedad cardiovascular?
Hoy #VisteteDeRojo y ayúdanos a esparcir la voz!
#GoRedForWomen @goredforwomen
https://t.co/kbNdkGy1L4
#cvImaging is undergoing a major transformation & this month's #CardiologyMag cover story explores the 🆕 multisociety Advanced Training Statement on Advanced Cardiovascular Imaging & its role in shaping future training pathways for evolving CV care. More: https://t.co/DzeWJr94cL
Si asistes al Congreso #SAC25 te esperamos en nuestro stand (núm 44)
Podrás adquirir nuestros libros
- Libro Azul
- Clínicas Interamericanas
- Cardiologia Crítica
Te esperamos!!!!
@SAC_54
Durante el Congreso #SIACprevent2025 se presentó un nuevo libro SIAC:
“Ateroesclerosis sublínicas: el valor de un diagnóstico temprano”
Editores: Dres. Adriana Puente, Vladimir Ullauri, Mildren del Sueldo, Yoloxochitl García Jiménez, Alberto Lorenzatti y Carlos Ponte
@acepuba@vladullauri1@Mdelsueldo@JYologarcia@ALorenzatti@DrPontecarlosi
FELICITACIONES!!!
Durante el Congreso #SIACprevent2025 se presentó un nuevo libro SIAC:
“Ateroesclerosis sublínicas: el valor de un diagnóstico temprano”
Editores: Dres. Adriana Puente, Vladimir Ullauri, Mildren del Sueldo, Yoloxochitl García Jiménez, Alberto Lorenzatti y Carlos Ponte
@acepuba@vladullauri1@Mdelsueldo@JYologarcia@ALorenzatti@DrPontecarlosi
FELICITACIONES!!!
We’re pleased to share the 2nd edition of Women Who Lead, featuring Dr. @AnaGMuneraE, President of @SIAC_cardio.
With 20+ years in CVD & pregnancy, she champions leadership & equity across the Americas.
Read her story (6-minute read): https://t.co/gNnJAbDqYn
#WomenInCardiology
Who better to have chairing this discussion panel than one of the trailblazers in Women's Cardiovascular Health - Prof C Noel Bairey Merz!😃
A truly amazing expert panel with fantastic discussions and insight from all!
SUCH a great pleasure to host these incredible experts! 😃