Adam Belsom

Developing crosslinking mass spectrometry; Researcher at the TU Berlin

[Rappsilber laboratory @RappsilberLab]

As a final note, sulfo-SDA crosslinks allow AlphaLink2 to position the viral protein within the Cullin4 complex's experimental density. (6/7)

[Rappsilber laboratory @RappsilberLab]

In collaboration with the @rbolab, we are pleased to present AlphaLink2 - a modified version of AlphaFold-Multimer that is capable of directly incorporating experimental residue-residue contact data from crosslinking MS (and potentially other techniques as well). (1/7)

[Rappsilber laboratory @RappsilberLab]

#AlphaLink2 goes #ColabFold 😎 @sokrypton #AlphaFold  https://t.co/21a9LeoMht https://t.co/LbMD8CL9PJ

[Rappsilber laboratory @RappsilberLab]

The AlphaLink2 paper is now online! It’s joint work with @rbolab and @JorgStulke. AlphaLink2 integrates crosslinking MS data into AlphaFold-Multimer. AlphaLink2 really shines for challenging targets like antigen-antibody complexes. https://t.co/G922oFtlCe

[JACS Au @JACS_Au]

Light-Induced Orthogonal Fragmentation of Crosslinked Peptides

Juri Rappsilber et al.

Check it out 👉 https://t.co/NRZ16zh7Hs

@EdinburghUni

[Adam Belsom @adambelsom]

@RappsilberLab @rbolab Exciting times! #RappsilberLab

[Rappsilber laboratory @RappsilberLab]

We and the @rbolab are excited to present AlphaLink https://t.co/RuZvaIehxd a modified version of the AlphaFold2 protein structure prediction algorithm that can directly incorporate experimental residue-residue contact data from crosslinking MS (and potentially other techniques)!

[Ana Perez @ana_aperezl]

Happy to share our latest work @ACSPublications from @RappsilberLab @adambelsom @RappsilberJuri A catalytic peptide to mediate bioorthogonal chemistry by synthesizing two anticancer drugs: paclitaxel and linifanib in lung cancer cells. https://t.co/0AKjU3mw9e

[Adam Belsom @adambelsom]

An open invitation to the Understudied Proteins Initiative | Nature Biotechnology - Sign up now! https://t.co/0SBnW8k6iH

[Adam Belsom @adambelsom]

Understudied proteins: opportunities and challenges for functional proteomics | Nature Methods - the Understudied Protein Initiative! Yeah https://t.co/lEF1Q73oBM

[Adam Belsom @adambelsom]

@Superzeman I'm glad you like it @Superzeman! I guess it is not sold yet because the market is deemed not ready. Photo-crosslinking in general is under-utilised, but has begun to take off. Maybe we should be asking others why they haven't used it yet? #photocrosslinkingMS

[317070 @317070]

Very happy to share my secret project for the last 3 years: we were busy getting AI to run a nuclear fusion reactor. Spoiler alert: it works!
Deep reinforcement learning is pretty great at working with sci-fi things where human intuitions tend to break down.

[Joost Snijder @joostsnijder]

Check out @Tp_woerner's latest on single particle charge detection MS @hecklab! He did an in-depth analysis of the stability of single ions in the Orbitrap leading to some big improvements in ion sampling and resolution. https://t.co/KDoytPaoUA

[Vance Crowe @VanceCrowe]

I asked @leecronin how he defines 'Life' when he says he's creating it from scratch.

His answer started with planes, and ended with my mind blown open —
https://t.co/la5EBVDUrD

[Adam Belsom @adambelsom]

@hecklab @NatureComms @UUBeta @Bijvoet_Centre Great work!

[Adam Belsom @adambelsom]

We are living in exciting times!

[Google DeepMind @GoogleDeepMind]

In a major scientific breakthrough, the latest version of #AlphaFold has been recognised as a solution to one of biology's grand challenges - the “protein folding problem”. It was validated today at #CASP14, the biennial Critical Assessment of protein Structure Prediction (1/3)

[Scheltema lab @[email protected] @xlinkx_pd]

Very excited to see this in print online!! Was a pleasure to work with Alexander Leitner and @RappsilberLab on these recommendations.

[Joost Snijder @joostsnijder]

Check out our new preprint on AAV capsid assembly! Great work by @Tp_woerner @hecklab. He used native MS to show that these capsids are super heterogeneous.
https://t.co/lFmZRGMrZF

[Frank Sobott @FrankSobott]

All crosslinkers out there in the world, please have a look at this: https://t.co/yxGsCyrL1F Major community effort, making the method more reliable and informative. Thanks to Alex Leitner and Juri Rappsilber for making this happen!

[Adam Belsom @adambelsom]

AddThis | Home https://t.co/KtliS6XM1o

Anatomy of a crosslinker