Ryan ang (bio/acc)

ex CFO @endrarediseases | Studying the languages of molecules & mycelium - DeSci advocate with @bio_hacker_dao. Building science that can’t be locked away.

[Ryan ang (bio/acc) @adeeeewarchive]

Free Peptide AI Assistant

Some platforms charge $99/mo for "AI-powered peptide guidance."

We think charging for publicly available information is absurd. Meet Peppy. Ask anything about peptides. Research, dosing, protocols, regulations.

[Ryan ang (bio/acc) @adeeeewarchive]

@Flynnjamm @jessewldn are you done with @Katch_live ? Tell me more about it or imma sell in loss

[Ryan ang (bio/acc) @adeeeewarchive]

@Flynnjamm @thiepv1 @Katch_live How tf there was unlimited sell pressure are selling the fee you claimed ?

[Bryan Johnson @bryan_johnson]

People mistakenly believe peptides are only good.

Peptides can be bad, too.

They can cause adverse effects. Some dangerous.

I did a peptide experiment and measured its effects in my body. The results are complicated.

I tried a peptide called CJC-1295.

It pushed my growth hormone up by ~8x. That’s good. That’s what it was supposed to do.

But, it also came with adverse effects:
> increased my morning fasted blood sugar up 20%
> increased stress hormone by 12%
> tanked my REM sleep by 23%
> made my pancreas work 53% harder and was still losing to rising blood glucose
> increased my insulin resistance by 50%

These were the most obvious side effects, and I only ran a very narrow panel for this experiment.

So I’m sure there’s more.

I stopped after two doses, without even reaching the intended target dose.

For those of you new to peptides, your body sends instructions to itself using tiny chemical messengers called peptides. There are thousands of them.

For example, GLP-1s are drugs that take an existing class of short-lived peptides and modify them to extend their activity duration, which turns them into drugs, following rigorous clinical testing.

CJC-1295 is one of those peptide-drugs. It tells your brain to release more growth hormone. Growth hormone is your body's signal to build muscle, repair tissue, and recover.

However, and like most grey market peptides, CJC-1295 did not succeed its clinical trial, and hence never became an “official” drug.

There is a version called CJC-1295 with DAC. DAC is an attachment glued onto the peptide that makes it last for days in your body instead of hours. One shot, longer effect, just like GLP-1s.

Why people use it: more growth hormone could mean better recovery, leaner body, faster healing.

The experiment I completed.

Two injections a week of CJC-1295 with DAC:
> 1.2 mg
> 1.8 mg

48 hours after the first injection I was nearly comatose. It felt like severe jet lag, the type you’d feel after traveling nine time zones. My sleep was wrecked and I felt continuously awful.

My REM sleep dropped by 23%. REM is when your brain processes memories and repairs itself. Less time for my brain to repair itself. During the experiment, I never felt rested and always fatigued.

Why we chose CJC-1295 with DAC.

Some will say we picked the wrong peptide. They will say I should have used a different version, CJC-1295 without DAC, mixed with another peptide called Ipamorelin. We went with CJC-1295 with DAC instead as it has the most controlled studies.

CJC-1295 with DAC has 2 controlled trials in healthy adults. Ipamorelin alone has 1 controlled trial in healthy adults, plus 1 study that failed when they tried it on bowel surgery patients. The mix of the two has zero controlled trials.

On Ipamorelin, it copies a chemical called ghrelin, the one that makes you hungry. On its own it gives you a quick burst of growth hormone that fades fast. It does not keep your longer acting growth signal (called IGF-1) up. Clinics mix Ipamorelin with CJC-1295 no-DAC because the two together are supposed to work better. But we don’t know if that’s accurate because we don’t have trial data.

This is a problem with peptides. Almost none of them have been tested properly. We are flying blind. Most of what people use is based on what someone said online, what a clinic claims, or what a friend reports from their subjective feelings.

Peptides have the potential to be great when well-studied.

[Ryan ang (bio/acc) @adeeeewarchive]

@BioProtocol 14 days is pretty long day, and i already made it free there, you can use it completly free

no need preasle. or staking bio etc etc

|https://t.co/PbBBASPmMn

[Ryan ang (bio/acc) @adeeeewarchive]

Free Peptide AI Assistant

Some platforms charge $99/mo for "AI-powered peptide guidance."

We think charging for publicly available information is absurd. Meet Peppy. Ask anything about peptides. Research, dosing, protocols, regulations.

[Ryan ang (bio/acc) @adeeeewarchive]

2,847 longevity pathway peptide analogs (senomorphic, sirtuin, autophagy & NAD+ boosters) just dropped as public-domain prior art (§102).

Full sequences, predicted structures, PK/PD models, and composite scores — all open on Zenodo and now integrated

This is part of the largest & highest-quality model-generated peptide library ever built specifically for DeSci longevity research. Still ~280,000 more high-edit-distance candidates with readiness tiers, zero gatekeeping.

No patents. No paywalls. Pure bio/acc acceleration.

Links:
https://t.co/HeYmbuJzF5

Building science that can’t be locked away with @bio_hacker_dao

DM @adeeeewarchive or [email protected] for outreach

[Ryan ang (bio/acc) @adeeeewarchive]

@William_fng if you want to learning something new about peptides i build free tools that all ppl can acces free

https://t.co/XryIPif8qU

[Ryan ang (bio/acc) @adeeeewarchive]

Free Peptide AI Assistant

Some platforms charge $99/mo for "AI-powered peptide guidance."

We think charging for publicly available information is absurd. Meet Peppy. Ask anything about peptides. Research, dosing, protocols, regulations.

[Ryan ang (bio/acc) @adeeeewarchive]

@0xdetweiler if you want to learning something new about peptides i build free tools that all ppl can acces free https://t.co/XryIPif8qU

[Ryan ang (bio/acc) @adeeeewarchive]

Free Peptide AI Assistant

Some platforms charge $99/mo for "AI-powered peptide guidance."

We think charging for publicly available information is absurd. Meet Peppy. Ask anything about peptides. Research, dosing, protocols, regulations.

[Ryan ang (bio/acc) @adeeeewarchive]

Longevity Biotech Atlas 🔥

Finally a real map of the entire ecosystem. Peptides + rejuvenation tech are cooking.

Building exactly in this lane with open AI tools for peptide discovery @PeptideIQ — no paywalls, pure DeSci acceleration.

This atlas is going to be core infrastructure. Count me in for updates 👀

[Ryan ang (bio/acc) @adeeeewarchive]

Superhuman Fund II 🔥

Peptides + human enhancement is exactly where the real acceleration is happening.

Been building open AI tools for peptide discovery (PeptideIQ) so researchers can move faster without paywalls or gatekeepers. Fully aligned with the bio/acc thesis — science that can’t be locked away.

Would love to see how y’all think about DeSci infrastructure & open data rails for these upgrades.

DM open if you wanna chat peptides / longevity stack 👀

@bio_hacker_dao

[Ryan ang (bio/acc) @adeeeewarchive]

Moving forward without human commentary will minimize the margin of error; science will be freer than ever before. 🥼

[PeptAI @peptai_]

Peptide drug discovery now has an autonomous pipeline.

A tool takes an input and returns an output. A sequence goes in, a structure comes back.

The decision of what to do with it, whether the structure is good enough, what to run next, whether the candidate advances, stays with the researcher.

An agent uses tools. It evaluates the output against a defined threshold, decides whether the candidate passes or fails, and triggers the next step without waiting for a human to interpret the result.

@peptai_ is built as a fleet of agents. Each agent targets a specific receptor and runs the full 9-gate pipeline: source novel candidates, calibrate the quality gates, run the computational analysis, and hand survivors to wet lab.

Today: GLP-1R (35 candidates advancing), KISS1R (2 out of 10 candidates advanced to G9):

Every agent runs 9 gates:

> G0: Pulls ChEMBL binding data for known agonists and non-binders, sets the per-gate baseline.

> G1-G3: AlphaFold and Boltz2. Structure quality, binding poses, contact conservation.

> G4-G5: PRODIGY for affinity, LiteFold's MD for stability.

> G6-G8: PROSPERousPlus, PlifePred, OpenSol, and ToxinPred3. Proteolytic stability, solubility, aggregation, off-target safety.

> G9: Wet lab handoff with @adaptyvbio. The goal is to have synthesis paid machine-to-machine via x402.

Only sequences that clear all G1 through G8 earn a synthesis recommendation. G9 is wet lab only and cannot be computationally overridden.

Every gate decision is published openly on Molecule Labs.

PeptAI is experimental and actively evolving. Gates, tools, and thresholds change as the pipeline learns.

[Ryan ang (bio/acc) @adeeeewarchive]

@Peptide_PulseHQ it's obvius the fee that generated i'll use to manage the tools so it can go completly free

[Ryan ang (bio/acc) @adeeeewarchive]

@multiverseJim @rimurucook @flaunchgg @0xnobi @techy0x @0xalwaysonchain @0xCaps @nobi my tools are free to use no need connect or anything
you will not get scam or drained on it... it's completly safe and free

[Ryan ang (bio/acc) @adeeeewarchive]

@0xnobi @multiverseJim @rimurucook @flaunchgg @techy0x @0xalwaysonchain @0xCaps @nobi how can ? my tools was not scam tools you can find any peptides on it and do research things

[Ryan ang (bio/acc) @adeeeewarchive]

@rimurucook @flaunchgg @0xnobi @techy0x @0xalwaysonchain @0xCaps thanks for your tag he already reachout my dms

[Ryan ang (bio/acc) @adeeeewarchive]

@rimurucook @flaunchgg @0xnobi @techy0x @0xalwaysonchain @0xCaps i tried to reach to nobi i guess he not yet see my dms

[Ryan ang (bio/acc) @adeeeewarchive]

@rimurucook @flaunchgg @0xnobi @techy0x @0xalwaysonchain @0xCaps i already do that it's obvius launch i do it becaus to manage the website i need to buy some API key on research peptides

[Ryan ang (bio/acc) @adeeeewarchive]

@NeoCallss @flaunchgg how can ?

[Ryan ang (bio/acc) @adeeeewarchive]

@alexabelonix @flaunchgg Some platforms charge $99/mo for "AI-powered peptide guidance." and i made it free 😆

[Ryan ang (bio/acc) @adeeeewarchive]

Free. Fully cited. Real-time. ->🌐 https://t.co/Gdu5ca0KUW

https://t.co/ifl7vC8zwy

[Ryan ang (bio/acc) @adeeeewarchive]

https://t.co/51GjQJQkAB

[Ryan ang (bio/acc) @adeeeewarchive]

Free Peptide AI Assistant

Some platforms charge $99/mo for "AI-powered peptide guidance."

We think charging for publicly available information is absurd. Meet Peppy. Ask anything about peptides. Research, dosing, protocols, regulations.

[Ryan ang (bio/acc) @adeeeewarchive]

If this is useful, share it with someone who's overpaying for information that should be free.

And if you know what you paid for a peptide, submit it anonymously on our cost page. More data makes this better for everyone.

[Ryan ang (bio/acc) @adeeeewarchive]

@peptides if you want to learning something new about peptides i build free tools that all ppl can acces free

https://t.co/ifl7vC8zwy

[Ryan ang (bio/acc) @adeeeewarchive]

https://t.co/51GjQJQkAB