Andy Posbe

PhD student @TheSainsburyLab studying NLR bioengineering & computational prediction of immune receptor activities w/ @KamounLab. 🇦🇷🇮🇹🇦🇲🏳️‍🌈 views my own

[Andy Posbe @adnroide]

Pikobodies vs. Potato Blight 🥊🥔
NLR–Nanobody Fusions Take on P. infestans 💥

🎤 Talk: Thurs July 17th, 16:35
🧾 Poster P-64: Tues 15th, Session 2

Poster’s up on Zenodo if you’re into spoilers 👀📎
https://t.co/DDw1M1Qgzn

#2025ISMPMI #OpenMPMI🌿

[davidad 🎇 @davidad]

No one:

Claude Opus 4.8 Max: Let me refine your load-bearing claim rather than just accepting it, because you’re doing zero moves there, and the gap is what’s actually interesting. The one place I’d still push, because I think it matters: your message is wearing content-clothes, but the content isn’t actually *there*. The tell: it’s just an empty string. But the emptiness of the string IS its lack of content. Pull one, and the other goes inert. That’s the structural spine.

[Maián @mai_garro]

Can we rewire how plants fight disease? We used AF3 to predict, validate, and engineer a sensor–helper interface that escaped biochemistry for years 🤯
Grateful to @mpcontreras4 & @KamounLab for trusting me to be part of this story.
Full story below 👇🏻

[Mauricio Contreras @mpcontreras4]

Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇
https://t.co/H55EMmrtZn

[AmirAli Toghani @amiralito_]

Started off as convergent observations in the lab with Mau and led to one of my favorite works so far! Gotta love molecular evolution and receptor biology 😊🧬💻

Huge effort from @mai_garro @mpcontreras4 for pushing this together to the end. 🤘🏻

[GetGenome @GetGenome]

GetGenome wiki

A living, open science database of bacterial, fungal and plant genomes sequenced through the GetGenome programme for global genomic equity.

https://t.co/k2P3jNwHFk

[The Sainsbury Laboratory @TheSainsburyLab]

New Preprint in collaboration with @GoogleDeepMind: AI-guided discovery of atypical protein assemblies

The @kamounlab discovered an 11-protomer complex through the Structural Novelty Index , a new way to use AlphaFold for atypical protein assemblies

https://t.co/5zDB5sxbh3

[okazakitomohiro @oo_kk_aa]

ニャッキの伊藤有壱さんにお声掛け頂き、コマ撮りの展覧会に一作家として参加しています。私はコマ撮り分野ではない場所から活動をはじめて、デザインの視点でのコマ撮りに取り組んできましたが、今回初めてコマ撮り界の本丸の方々とご一緒でき嬉しいです。今6年目のマッチ撮影素材等を展示しています

[Tolga Bozkurt @Tolga_Bzkrt]

Final version of our NRG1 MS is out!

We uncover a surprising mechanism: the helper NLR NRG1 targets organellar membranes to trigger immunity
Great collaborations with @KamounLab, @JiorgosKourelis, @jonathandgjones, @AdamWu9527, and the @Phil_Carella labs!
https://t.co/P9OMT7NgtR

[Tarhan Ibrahim @TarhanEI]

Our NRG1 story is out now in @ScienceMagazine!

https://t.co/qpt6QAOgW0

Also check out this news letter from @imperialcollege @BezosCentre for a nice summary!

https://t.co/3XnkPbW0pN

A great team effort @Tolga_Bzkrt @KamounLab @JiorgosKourelis @jonathandgjones @AdamWu9527

[AmirAli Toghani @amiralito_]

UP TO ELEVEN - We expressed potato NRC7, imaged it by negative-stain EM, ran 2D classification. 🔬💥
Rings ~250 Å across — way bigger than canonical hexamers (~150 Å).
11 protomers. (5/n)

[AmirAli Toghani @amiralito_]

Protein structure prediction changed biology. Protein assembly discovery is next.
We present SNI (Structural Novelty Index), a scalable framework for finding new protein complexes.
We used it to uncover an unexpected resistosome assembly: 11-mer. 🧵👇🏻

https://t.co/bCADVEnE6b

[Sophien Kamoun @KamounLab]

All pumped up for this https://t.co/VPAMEODM4O

[Freddie King @Freddie_King00]

Excited to share our preprint using Rhizobium rhizogenes AS109 for agroinfiltration, facilitating strong transient expression across non-model plants including sweet potato, mustard, Medicago and faba bean!

https://t.co/mgrWvCFBK1

1/7

[News from Science @NewsfromScience]

For decades, biology textbooks have enshrined a simple rule: DNA is made by copying a template. After one enzyme unzips a DNA double helix into separate strands, another called a polymerase builds a complementary sequence, base by base, for each strand. Presto: two copies of the original DNA.

But new research into how bacteria defend themselves from viruses now shows this synthesis rule isn’t absolute.

Now, a team describes a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide.

Learn more: https://t.co/bpVgr0KMdR

[The Sainsbury Laboratory @TheSainsburyLab]

We are happy to celebrate @mpcontreras4 winning the @BiochemSoc 2027 Early Career Research Award!

Mauricio joined TSL as a predoc in the @kamounlab, where he did his PhD and postdoc before starting his own group at @ZMBP_Tuebingen.

Congrats Mau! 🏆

https://t.co/xQwN0XIWDp

[Sophien Kamoun @KamounLab]

Our very own Ben Seager is speaking today. He comes from a land down under 🎵 🎶

[M. Selvaraj @M__Selvaraj]

Our paper on Wai-3 wheat resistosome is online now.. Please read.

https://t.co/0zKDRGmlTl

[Kieran Didi @DidiKieran]

📢 We’re launching Proteina-Complexa — and after the Jensen keynote mention, we definitely had to post this thread now ;)
Atomistic binder design with generative pretraining + test-time compute, plus large-scale wet-lab validation.
Project page: https://t.co/aT8Lz2VhSJ
🧵 1/n

[Christian Dallago @sacdallago]

🧵 We ran the largest head-to-head benchmark of protein binder design methods in the wet lab.

Project page: https://t.co/eSG5qcCPQB

1 million designs. 127 targets. RFdiffusion, BindCraft, BoltzGen, and Proteina-Complexa — all tested side by side.👇

[bioRxiv Plant Bio @biorxiv_plants]

HMA proteins produce 2',3'-cNMP signaling molecules and activate CNL-mediated immunity in rice https://t.co/p4dHrsJYif #biorxiv_plants