We're looking for a senior level resident/early career faculty to join our team as an Associate Editor to help with
✅reviewing new case submissions
✅collaborating with case submitters and experts in the field
Learn more: https://t.co/QEISNP9tmm
📅Due August 15!
Happy 250th birthday, America! We got you a present. 🇺🇸
The red, white, and blue stars of this globular cluster shine like a sparkler waved on a dark night in this image from @NASAHubble, released in celebration of the United States' 250th anniversary.
🚨 NRGGU006: prospectively validated 🎯 PAM50 = predictive 🔬 biomarker for ARPI in #ProstateCancer!
Adding apalutamide 💊 to salvage RT (no ADT) boosted 5-yr bPFS (72% vs 54%) & MFS (95% vs 82%) in luminal B tumors ➡️ no benefit in others. @DrSpratticus#ASTRO25#RadOnc
Comparison of toxicity w 3D v IMRT in RAPIDO: IMRT worse.
Table summarizes studies of 3D v IMRT in rectal ca – w RAPIDO, data mixed.
Caveat that RAPIDO didn’t require OAR delineation/ specify constraints, but good reminder that advanced tech doesn’t guarantee better outcomes.
#ESTRO25 has come to an end. Really enthusiastic being in the ESTRO25 mentoring programme ! The guidance of an experienced mentor is invaluable for young radiation oncologists, offering critical support as they develop clinical expertise and professional identity. Looking forward
STORM-PEACE V trial reported by @ZilliThomas#ESTRO25
Pelvic ENI superior to MDT for pelvic relapses after local Tx for #prostate cancer (6mo ADT each)
Improves
Biochemical PFS
Locoregional PFS
MFS
ADT free survival
Tox NS
ENI clear SOC
Online @TheLancetOncol
Cc @piet_ost
Live from #ESTRO25:
From STOMP , EXTEND to RADIOSA and 🔜 X-MET—the evidence is growing:
✅SBRT alone is good.
🌟🌟 🔥SBRT + ADT is better.
Personalized MDT strategies are here to stay.
Stronger together 💪🏻🙌.
#PCa#SBRT#MDT#XMET
BCT is safe & effective for BRCA1/2 carriers—no impact on OS or DMFS
CBC risk (esp. in BRCA1) supports considering bilateral mastectomy
Personalised decisions, early BRCA testing & expert counselling are key
#ESTRO25#BreastCancer#OncoAlert@OncoAlert@UNI_FIRENZE@AOUCareggi
“Primary end-point met!
The shorter, reduced dose IMRT regimen offers major advantages to patients. “
Can we start applying this into practice ? Or should we be more prudent because it is just a phase 2 trial ?
Great presentation by @MontefioreD regarding the results of the de-escalation radiotherapy in the PLATO ACT 4 trial which have been just published today.
Phase 2 trial, T1-T2 N0/NX 2:1 reduced dose IMRT vs standard dose.
GTV 41.4 Gy in 23 fr and CTV 34.5Gy in 23 fr vs GTV 50,4 Gy/28 fr and CTV 40 Gy in 28 fr.
Both arms associated with standard concomitent chemo MMC 12 mg/m2 Day 1 and Capecitabine 825mg/m2 BD po on RT days.
Bounce (defined as an increase > 0.2 ng/mL) following ultra hypofrac #radiotherapy, is frequent (36%) & associated with improved prognosis.
Data from HYPO RT PC at #ESTRO25
Possible bias (bounces by definition have a decrease in PSA after the rise) role of 3y landmark analysis
4.1 years follow up of DBCG Skagen trial showed that 40Gy/ 15 does not cause > lymphedema vs 50Gy /25
The risk of LRF, DM and death not higher with 40Gy/15 vs 50Gy/25. However BCM higher using 40Gy/15, raising concerns.
BC was worse with 40Gy/15 in all subgroups tested. #ESTRO25
Results from the 10-year efficacy and late normal tissue effects in the *FAST-Forward* randomised trial, confirm 26Gy/5Fr as appropriate SOC for breast/chest wall/ partial irradiation. presentation by Brunt Adrian Murray at #ESTRO25