Michael Weiss

Solve aging, end disease / Interested in partial reprogramming / Co-Founder of the AI industry's annual conference @ai4conferences & prev. @longevitysummit

[Jacob Kimmel @jacobkimmel]

in our 2026 @newlimit progress update, we announced our first candidate medicine.

it has the one of the most striking effects i’ve ever seen.

a single treatment accelerates recovery from alcohol in old animals. it’s so dramatic you can see it with your bare eyes!

[vittorio @IterIntellectus]

this is actually insane

> be tech guy in australia
> adopt cancer riddled rescue dog, months to live
> not_going_to_give_you_up.mp4
> pay $3,000 to sequence her tumor DNA
> feed it to ChatGPT and AlphaFold
> zero background in biology
> identify mutated proteins, match them to drug targets
> design a custom mRNA cancer vaccine from scratch
> genomics professor is “gobsmacked” that some puppy lover did this on his own
> need ethics approval to administer it
> red tape takes longer than designing the vaccine
> 3 months, finally approved
> drive 10 hours to get rosie her first injection
> tumor halves
> coat gets glossy again
> dog is alive and happy
> professor: “if we can do this for a dog, why aren’t we rolling this out to humans?”

one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline.

we are going to cure so many diseases.
I dont think people realize how good things are going to get

[Bo Wang @BoWang87]

I’m not an aging biologist, but I have to say — @davidasinclair is one of the clearest science communicators out there.

The way he explains aging really stuck with me:
it’s not just “damage,” it’s loss of biological information.
And in theory, information can be restored.

75% age reversal in animals in 6 weeks.
FDA-cleared human trial now underway.

Video source : @vitrupo

[Michael Weiss @ahumanmichael]

The recording of history should be a raw data feed of the present.

Let the future interpret the data as they see fit.

[David Sinclair @davidasinclair]

In the future, we will be shocked people once waited to get a disease before they were treated

[Aravind Srinivas @AravSrinivas]

Demis is a genius and he should be given all resources in the world to make this happen.

[Bo Wang @BoWang87]

Shift Bio is leading the way in using foundation models for rejuvenation research! Excited to see the breakthroughs they’ll bring in the years ahead!

[vittorio @IterIntellectus]

HOLY SHIT IT'S HAPPENING

AI can now write genomes from scratch.
Arc Institute an NVIDIA just published Evo-2, the largest AI model for biology, trained on 9.3 trillion DNA base pairs spanning the entire tree of life.

it doesn’t just analyze genomes. it creates them
1/

[Michael Weiss @ahumanmichael]

Healing has always been a reactive practice.

When someone gets sick or hurt and shows symptoms is when treatment gets applied.

The shift to proactive medicine is what longevity biotech / regenerative medicine / aging interventions are all about.

The only symptoms humans of the near future should suffer from is a bioclock that says a bit of aging occurred.

[Michael Weiss @ahumanmichael]

Bold statement, but it's great getting more people to attach health and longevity to AI's progress.

[AshutoshShrivastava @ai_for_success]

Dario Amodei : AI could double lifespans in 5 years.

Thoughts??

[Michael Weiss @ahumanmichael]

It's so cool this happened, let alone 60 years ago...

In 1962, Gurdon discovered that the specialization of cells is reversible. He replaced the nucleus of a frog egg cell with the nucleus of a mature intestinal cell, and the egg cell developed into a tadpole.

[Pearl Freier @PearlF]

FT reports from Davos that Isomorphic Labs' co-founder said they'll have an AI-designed drug in trials by end of '25. "We’re looking at oncology, cardiovascular, neurodegeneration, all the big disease areas, & I think by the end of this year, we’ll have our 1st drug." Link: https://t.co/1Hr9USt7ia

[Chan Zuckerberg Initiative @ChanZuckerberg]

It’s an incredible time in biomedicine. We’re applying advances in large language models to accelerate research.

We recently shared initial cell models that will help researchers discover the cellular basis of health & disease, with lots more to come https://t.co/1IInT7ly8R

[vittorio @IterIntellectus]

sam altman: “we will see diseases get cured at an unprecedented rate … what this will do to cure the diseases at a rapid rapid rate”

immortality is not too far ahead. we live in the most incredible of times

[Michael Weiss @ahumanmichael]

That may be the case, but since we can change somatic mutations through epigenetic tinkering (ie oskm), this zinger ain’t so zingy.

[Buck Institute @BuckInstitute]

Reconciling 2 major explanations for #aging, study in @NatureAging finds somatic mutations are fundamental driver of aging and #epigenetic changes simply track process. Reversing aging may be harder than previously thought. Time to rethink strategies?
https://t.co/7oH1ks04zw

[Longevity Biotech Fellowship @LBF_org]

1/ 🧵Announcing CORHORT 6 of the Longevity Biotech Fellowship —the most hardcore community of longevity accelerationists! Join 700 members working to SOLVE aging entirely.

⌛️Deadline: Mar 14
Kickoff Retreat: Mar 31 - Apr 4 in Berkeley.

👉Apply: https://t.co/1fuIo0jZ5r

[Peter H. Diamandis, MD @PeterDiamandis]

I’ve allocated $650,000 to longevity. Aging is the world’s largest untapped market...here's why:

[Antonio Regalado @antonioregalado]

OpenAI built a model to improve "reprogramming" of cells by suggesting how to re-engineer Yamanaka factors.

Did the work with Retro Bio, longevity company funded by Sam Altman.

https://t.co/E6yIKvLw3R

[Alex Colville @AlexJColville]

This tweet just made the @WSJ! @X helping to make news yet again. We’re in a once in a decade, 2 month window for policy change to catalyze a world for longevity interventions to help prevent awful diseases. What do ppl think is most impactful lever that the new admin can pull?!?

[Michael Weiss @ahumanmichael]

Gene editing > epigenome editing > what’s next?