Aessandra Fiore

[Aessandra Fiore @aleflow3r]

I am deeply grateful to all coauthors and collaborators @University of Verona for their dedication, expertise, and teamwork throughout this project. A special thank you to our funding agencies, @AIRC_it and #FIS3, for making this work possible.

[Aessandra Fiore @aleflow3r]

🚀 I'm over the moon to share that our latest research has been published in Molecular Cancer!

📝 Metabolic plasticity underlies ferroptosis resistance driven by mutant p53 in pancreatic ductal adenocarcinoma
by Adriana Celesia et al.
🔗 Read it here: https://t.co/Lu04cX57hK

[Aessandra Fiore @aleflow3r]

We show that pharmacological reactivation of wild-type p53 disrupts this adaptive program, restores ferroptosis sensitivity, and significantly enhances cancer cell death both in vitro and in vivo.

[Aessandra Fiore @aleflow3r]

In our study we demonstrate that mutant p53 promotes resistance to ferroptosis by orchestrating a metabolic adaptation that preserves mitochondrial function and rewires cellular metabolism. This metabolic plasticity enables pancreatic cancer cells to withstand ferroptotic stress.

[Aessandra Fiore @aleflow3r]

Thrilled and grateful to share that I’ve been awarded a FIS3 Grant (€1.3M) for the FerroPan project!
In the next 5 years, we’ll explore ferroptosis and metabolic pathways to push toward a real shift in PDAC therapy.
Looking forward to 5 years of exciting science🔥

[Sorrell Lab @Sorrell_Lab]

Excited to share our study showing that dietary depletion tryptophan has profound effects on liver cancer. Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis https://t.co/gzcuNC0LXy
Thank you @Zhu_Lab, @RJDLab, @ASolmonson, and Jerry Shay

[Rosenblatt Lab @RosenblattLab]

After ~12 years of hard labor, lots of push back and excitement, we are pleased to present our paper showing a new mechanism for the many features of asthma that came out in Science today with an awesome review by Jeffrey Drazen and Jeffrey Fredberg.https://t.co/weExktome9

[Fondazione AIRC per la ricerca sul cancro @AIRC_it]

Si sono aperti questa mattina I Giorni della Ricerca, la nostra campagna che da quasi 30 anni si pone l'obiettivo di informare sui più recenti progressi della ricerca oncologica e raccogliere nuove risorse da destinare al lavoro dei ricercatori.

Il ricco palinsesto di appuntamenti dei Giorni della Ricerca è iniziato con la Cerimonia a Palazzo del Quirinale, durante la quale il Presidente della Repubblica Italiana Sergio Mattarella ha consegnato il premio AIRC “Credere nella Ricerca” a @FederfarmaITA, per l’impegno profuso in attività di sensibilizzazione e in iniziative per il sostegno alla ricerca sul cancro; ad Antonio Pescapé dell’Università Federico II di Napoli, per aver contribuito a diffondere la conoscenza della missione di Fondazione AIRC tra le nuove generazioni; a Mara Venier per il suo impegno continuativo a fianco di AIRC nel sostenere la ricerca sul cancro attraverso le trasmissioni televisive. Il Premio scientifico biennale AIRC “Beppe della Porta” è stato consegnato ad Andrea Necchi dell’Ospedale San Raffaele di Milano per gli studi pioneristici sull’utilizzo dell’immunoterapia neoadiuvante nel carcinoma della vescica.

Sono intervenuti Andrea Sironi, Presidente AIRC, Federico Caligaris Cappio, Direttore scientifico AIRC, Luca Boldrini, oncologo e ricercatore al Policlinico Gemelli di Roma, la Ministra dell'Università e della Ricerca @BerniniAM e il Ministro della Salute Orazio Schillaci.

#IGiornidellaRicerca

[Stefano Ugel @StefanoUgel]

Happy to share a link to our recent article published in Oncoimmunology 😉. We demonstrated the ability of immune checkpoint inhibitor therapy to mitigate systemic inflammation and impair MDSC dependent immunosuppression.🎯

https://t.co/ttDlQtd0yZ

[Aessandra Fiore @aleflow3r]

Powerful message and inspiring science from Maya Schuldiner at #FEBS2023

[Aessandra Fiore @aleflow3r]

Great talk from our @Federica_Danzi at the #Febs2023

[Molecular Oncology @MolOncology]

@Federica_Danzi concludes the Cancer and Aging session at
#FEBS2023 with insights into how #TP53 influences signaling in #PDAC and chemoresistance

[Peter J Murray @pjmurray_lab]

Do you want to learn about how regulated tryptophan metabolism controls immune responses? This review coalesces a lot of very new, and older, research to give an overview of IL4i1 and IDO1 immunometabolism. https://t.co/v5Xzvklb17

[Stefan Ledinger @SLedinger]

As the field of metabolomics advances, a theme is emerging in my recent discussions: metabolomics data can be especially powerful when combined with other methodologies, capitalizing on the strenghts of different technologies. Mult…https://t.co/gYtxq8YPa2 https://t.co/lIXqFWJrnh

[Metabolomics Papers @Metabbot]

To metabolomics and beyond: a technological portfolio to investigate cancer metabolism. Signal Transduct Target Ther #metabolomics https://t.co/dUiFwqyXQy

[Aessandra Fiore @aleflow3r]

Delighted to see our last review online in Signal Transduction and Targeted Therapy: "To metabolomics and beyond: a technological portfolio to investigate cancer metabolism". Excellent job of @Federica_Danzi 🔥 https://t.co/Dush6yazhC

[Aessandra Fiore @aleflow3r]

#sciencegreetings #biorender @BioRender

[Aessandra Fiore @aleflow3r]

📣Beyond excited to share that my #MFGA has been funded. For the next 5 years we'll be working on understanding the role of mutant p53 in regulating ferroptosis in #PancreaticCancer📣#myfirstgrant #Airc Thanks to @AIRC_it and @UniVerona

[Aessandra Fiore @aleflow3r]

📣Very excited to see this paper finally out!Great job from @JoBaBrue and @pjmurray_lab in dissecting how Torins regulate the GCN2 pathway📣

[Peter J Murray @pjmurray_lab]

This is our current model for how torins block GCN2 activity from @JoBaBrue’s paper https://t.co/kH7e3qpyBd.

[Oded Rechavi @OdedRechavi]

Early career researcher