Alejo Rodriguez-Fraticelli

Quantitative analysis of aging/cancer heterogeneity - @fraticellilab @icreacommunity @IRBbarcelona @ERC_research @criscancer @CaixaResearch 🇦🇷🇪🇺🇺🇸

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

🚨 NEW @FraticelliLab PREPRINT JUST WENT LIVE

https://t.co/cauXJei5Ji

Here, we describe PLSTCs, Soluplus-based expansion cultures of primary mouse *Acute Myeloid Leukemia* Stem Cells. And then we use LARRY barcoding to identify drivers of leukemogenicity and drug resistance!

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

Hilarious

[Artemy Shumskiy @ArtemyShumskiy]

which ones are missing?

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

@NatReglero @Juanaloca2002 @FundacionAZ @canceryconmetas Congrats Nat!!!! Super well deserved! Keep crushing it!

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

@saima_lab You’re killing it Sai!!!! Amazing!!!! Top of the read pile for us!

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

One of the most important papers of the field in years…. Congrats to the team!

[Caroline Watson @carolinewatson]

How does leukaemia develop? 🩸 How long does it take? ⏳

🌟 Our paper, started back when I was a PhD student in @jrblundell’s lab, is out today in @Nature 🌟

Yearly blood samples from women who developed AML in later life let us trace it back decades 👇
https://t.co/fqyOpc5OKH

[NYGCtech @NYGCtech]

Excited to share our latest preprint! 🎉

SPACE-Tag enables high-throughput spatial chromatin profiling with CUT&Tag.

Huge congrats to Chao, Ruiyang, Sara, Maros, Silas, Ivan, and Sanja! 👏

🔬 https://t.co/Vu14nO7m60

[Josep Carreras Leukaemia Research Institute (IJC) @CarrerasIJC]

🧬 A new study in @Nature, co-led by IJC Director Ari Melnick, shows how mutations in the BAF complex alter the 3D organisation of DNA and can contribute to B-cell lymphoma development in experimental models.

🔗 https://t.co/lrkHWENRKf

[Iñaki Ruiz-Trillo @multicellgenome]

How do cells aggregate and then separate again?
In our updated preprint, we combine experiments & mathematical modelling in a unicellul relative of animals, to provide a framework to ask how genes shared with animals contribute to collective cell behaviour
https://t.co/CCOU4QxZ2Z

[Efeyan Lab @EfeyanLab]

Más allá del titular clickbait, una buena conversación con la periodista Paka Diaz sobre los esfuerzos de mi labo para entender y targetear el metabolismo del cáncer de hígado. @criscancer @CNIOStopCancer https://t.co/6FhhED56nt

[Nina Cabezas-Wallscheid @Nina_CabezasW]

Extremely excited to share our lab's latest findings, now published in Blood 👏🏻🥳 @BloodPortfolio !
We show that young MPP6 is a long-term, lymphoid-biased population with HSC-like properties. Strikingly, upon aging.. 1/5
https://t.co/7UGOcVZS2z

[Mari Carmen Romero-Mulero @MCRomeroMulero]

Our new story is published in Blood! 🩸

Research on blood aging has mainly focused on hematopoietic stem cells (HSCs), while the multipotent progenitors downstream of them, especially the CD150⁻ MPP6, have remained largely overlooked.

https://t.co/YjFLmztIXx

[Kevin Perez @kgiperez]

Can a photo tell how old a mouse is? 📸🐭
We trained a model on 2,846 photos of 1,292 mice from 7 facilities. Mice that look older than their age are frailer and die sooner, and telomerase-deficient G4 mice look ~5 months older.
Preprint ⬇️

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

It’s been a few days and I still can’t fully cope with this pain. I’ve been having panic attacks just thinking of what her family must be going through right now.

Marta Shabazi was much more to me than a classmate, or a colleague. She was in many ways what I always hoped to become. She made it look easy to balance family and science in a calm and joyful way that I had never seen before, and I have admired her for as long as I remember (and of course she knew it, as I told her more than a few times). She had a positive and optimistic attitude towards everything that was contagious to the extreme.

Whenever I think an experiment is impossible, or another play date is throwing my week off… I can still imagine her looking at me telling me that you gotta throw at it all you’ve got.

I will miss you Marta.

[Dan Landau @landau_lab]

Faculty ad is out,

please help spread the word

Come #DreamBig together, without a doubt,

in the best city in the world!

https://t.co/dhSlHbbfJ0

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

I would join this without blinking! Don’t sleep on this one, folks!

[Dan Landau @landau_lab]

🚨We're recruiting! Calling all bold & original thinkers! Folks with imagination, drive & the (rare) ability to find the thin seam where the fantastical and real meet. Come join a thriving science community, in, beyond a shadow of a doubt, the greatest city in the 🌎 @nyknicks

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

@TzelepisLab @Nature @SCICambridge @Cambridge_Haem @Cambridge_Uni But it’s true!!!! Historical collaboration in the making. I’m already looking forward to the trial data!

[Kostas Tzelepis @TzelepisLab]

Today in @Nature we present the development and characterisation of the first-in-class catalytic inhibitor of METTL1 as a new therapeutic strategy against solid and blood cancers.

Another flagship collaboration between my lab @SCICambridge @Cambridge_Haem (@Cambridge_Uni) and @storm_tx, co-led by my brilliant colleague @OliverRausch and driven by Eliza Yankova, Alexandra Sapetschnig and Beth Thomas.

A big thank you to the long list of authors who participated in this study and provided their critical input and diverse expertise. I am also very thankful and lucky to have the continuous support of @wellcometrust, @LeukUK and @CR_UK.

https://t.co/jODFOc9kDq

[Jay Shendure @JShendure]

Our latest, sent on behalf of the outstanding but X-less Aidan Keith: OPTIMuS PRIME-Del uses paired prime editing to program targeted deletions at candidate enhancers, while concurrently replacing them w/ a molecular tag to verify & quantify deletions 1/7
https://t.co/iq41mejHGG

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

@GuiuLab @NatureComms SUPER INTERESTING!!!! IFNg mediates intestinal stem cell inflammatory memory!

[Jordi Guiu @GuiuLab]

Thrilled to share our latest publication in @NatureComms !

Can the intestine remember a previous injury?

We show that intestinal injury leaves a lasting transcriptional and epigenetic imprint that primes the tissue for enhanced regeneration.

https://t.co/7EGJCwRpWo