Alice Chen

[Alice Chen @alice_mc_chen]

Big news in pancreatic research! 🙌
A long-awaited single-cell isolation method for pancreatic acinar cells has finally been published, and it was developed by none other than my talented colleague, @NiravFC! 🎉

[Nirav Florian Chhabra @NiravFC]

📢Finally out in @CellRepMethods! We developed DCTC — an isolation protocol for live cells from murine pancreas
✅No fixation or dead cell removal
✅80-90% acinar cells
⚡️Uncovered acinar cell heterogeneity & ADM dynamics
⭐️scRNA-seq | fow cytometry
📄https://t.co/LWAEqzsQIL

[Erman Akkus @Erman_Akkus]

🚀Eleven clinical trials that will shape medicine in 2026

👉https://t.co/uKrOcFPYN6

#science #research #MedX @1989_mariab @World_Data_A @OncoAlert @DeryaTR_

[William A. Wallace, Ph.D. @WilliamWallace]

A simple guide to how mitochondria work. 4️⃣ primar jobs

Mitochondria are more than the “powerhouse of the cell.” They’re multitasking organelles that control energy, stress, genetics, and even cell survival. Here are the 4 primary jobs they do:

1️⃣ ATP Generation (Energy Production)

Mitochondria convert glucose, fats, and amino acids into acetyl-CoA, which enters the TCA cycle and electron transport chain (ETC).

The result: ATP, the energy currency for everything from nerve signals to muscle contractions.

🟢 Example: Every time you move or think, mitochondria are fueling the process.

2️⃣ ROS Balance - i.e., redox control

As mitochondria make ATP, they also generate reactive oxygen species (ROS) damaging byproducts.

Antioxidant enzymes (like catalase, SOD, glutathione peroxidase) keep ROS under control.

Too much ROS = oxidative stress → cell injury or death.

🟢 Example: Exercise trains mitochondria to better balance ROS, which is one reason it’s so protective.

3️⃣ mtDNA Maintenance (genetic stability)

Mitochondria have their own DNA (mtDNA), which encodes key ETC proteins.

Damage or mutations in mtDNA reduce energy output and contribute to diseases.

mtDNA mutations accumulate with age, linking mitochondria to neurodegeneration and aging.

🟢 Example: Mitochondrial DNA damage is a hallmark in Alzheimer’s and Parkinson’s disease.

4️⃣ Membrane Dynamics (fission & fusion)

Mitochondria constantly split (fission) and merge (fusion) to adapt to stress and demand.

This dynamic reshaping controls quality, removing damaged mitochondria (mitophagy) and keeping networks healthy.

🟢 Example: Impaired fission/fusion is seen in metabolic disorders and neurodegenerative disease.

Mitochondria don’t just make energy. They balance oxidative stress, protect genetic integrity, and constantly remodel themselves to keep cells alive. Supporting mitochondrial health means supporting the foundation of cellular life.

[Cancer Discovery @CD_AACR]

Read this week's Cancer Discovery #ResearchWatch: Cancer Cells Induce T-Cell Dysfunction Through Mitochondrial Transfer https://t.co/1QRlfXKo3l
A summary of the study by Hideki Ikeda, Yosuke Togashi, and colleagues at Okayama University

[Anirban Maitra @Aiims1742]

The new issue of @Cancer_Cell is online - usual eye catching @CellPressNews cover.
An #OpenAccess review on the emerging role of myeloid effector cells in tumor rejection - an updated tumor-immunity cycle, now with reprogrammed/activated myeloid effector cells factored in.

[Thierry Nordmann @NordmannThierry]

Published today! Spatial proteomics reveals JAK/STAT as a target for Toxic Epidermal Necrolysis, an often fatal skin reaction to common medication. We validated our findings in pre-clinical models & successfully treated the first patients worldwide.🧵⬇️ https://t.co/JLHOSf6IAv

[Dr Honey choudhary 🩺 @Doctors__squad]

Blood pressure medications

[Nirav Florian Chhabra @NiravFC]

📢#Metabolic reprogramming in early stage of #PancreaticCancer can be targeted to Inhibit #ADM
@alice_mc_chen @yhnb4f4yqb
https://t.co/ZoW1lPBXz6

[Scholarship for PhD @ScholarshipfPhd]

Structure of Scientific Article

[Wyss Institute @wyssinstitute]

Researchers at the Wyss have developed cellular "backpacks" for macrophages to release a steady stream of cytokines, keeping them activated against cancer.
https://t.co/RtOypAFwUL