Amshan Ashraf

brb trying something

[Amshan Ashraf @amshan]

I just did an audit on my life for the last six months. I've gotten rid of 7 out of the 11 bad habits I've been trying to wipe out and added 9 out of 14 new healthy habits I set out to create.

[GREG ISENBERG @gregisenberg]

I just got back from SF and I FEEL INSPIRED.

I spent 5 days with frontier AI model teams, AI startup founders, and 3 billionaires.

My takeaways:

1. I had lunch with 3 billionaires. All of them are buying SaaS companies and rebuilding them agent-first. They were deeply inspired by Bending Spoons and Ryan Cohen's eBay deal. Buy the company, cut the headcount, rebuild the tech, add agents, add features, make more valuable experience, raise prices.

2. The frontier model companies are hungry for usage data from the field. They can see API calls and token counts. They can't see the actual workflows. If you're deep in a niche using these models in ways the model companies haven't seen, that understanding is incredibly valuable. Usage intelligence is the new alpha.

3. Consumer AI is massively underbuilt. Every billboard in SF is either B2B inference infrastructure or vertical agent companies. The entire city is optimized for enterprise. Meanwhile you have companies like Cal AI doing $50M ARR in 18 months as a consumer app. I met with a cool few teams doing consumer AI (@paulscherer / @ekuyda)

4. MCP came up in literally every conversation. The companies exposing their product as MCP endpoints are getting pulled into deals they never pitched for. The ones that aren't are becoming invisible to agents. This is the new SEO. If agents can't find you, you don't exist. Building products for agents is the new zeitgeist in general.

5. Not uncommon for hot seed rounds to be $25-50 million valuations. I saw a Series A at $450 million

6. If I had a dollar every time someone mentioned "forward-deployed engineer" this trip I could have funded a seed round. It's the hottest role in SF right now. The person who sits between the agent and the customer, making sure everything actually works.

7. The mood around open source shifted. A year ago it felt like open source was chasing the frontier models. Now founders are telling me Gemma and DeepSeek are good enough for 80% of what they need at a fraction of the cost. The "which model do you use" conversation is being replaced by "which model for which task." Model loyalty kinda feels dead.

8. Voice agents came up more than I expected. Multiple founders told me voice is the interface for the next billion users. The billion people who will never type a prompt will absolutely talk to one.

9. The Obsidian community in SF is weirdly intense. Multiple founders showed me their vaults unprompted. Like showing someone your home gym. It's a flex now. The quality of your knowledge base (second brain?) is becoming a status symbol among builders.

10. Maybe it was just the people I met but the age of the founders is shifting. I met more founders over 40 this trip than any trip before and more founders under age 21 than ever before. Founders getting older and younger at the same time.

11. I spoke to a lot of fast-growing startups, VCs and frontier models who are hiring content creators right now.

12. The restaurant scene in SF is actually better than it's been in years. Founders are going out more. Alcohol is out, not surprisingly.

13. SF doesn't feel like the only place anymore. We all have access to the same frontier models. We all read the same X feed. A founder in NYC or Lagos is calling the same APIs as a founder in SoMa. So in the past it felt like SF was always lightyears ahead, doesn't feel that way anymore. It's okay not to live in SF and have BIG DREAMS.

14. The coworking spaces in SF are half empty but the coffee shops are packed. People want to be around people. I had a few startup ideas here....

15. Walking around the Mission I noticed something: the street-level businesses, the taquerias, the barbershops, the laundromats, none of them use any AI at all.

16. I heard the phrase "agent debt" for the first time. Like technical debt but for agents. When you hack together an agent workflow fast and never clean it up, the system prompts conflict, the memory gets polluted, the tools overlap. 6 months later the agent is doing weird things and nobody knows why lol.

17. Met a few people who carry two phones now. One for personal. One that's basically an agent terminal running Telegram or iMessage connections to their agent fleet.

It's always amazing to get that dose of inspiration in SF. I FEEL INSPIRED.

But I'm so happy to be back home, locked in and building.

We're 12-18 months into a shift that will take 15 years to play out. The urgency in every conversation was real.

What an incredible time to be building.

[Crémieux @cremieuxrecueil]

Eli Lilly has done it.

They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol.

That means they'll be able to effectively prevent most heart disease with a single infusion!

[Mitchell Hashimoto @mitchellh]

Fork your dependencies, trim them to only your use case, never update unless it breaks for your users. I’ve been vocal about this for 10+ years. I’ve always said that updating is way riskier than latent bugs (which can be tracked and CVEs monitored).

If you are updating a dependency, it’s on you to analyze every single commit in the full transitive set of dependencies. If you dont see anything compelling, dont update!

I remember at HashiCorp once in awhile an engineer would try to update a dep or replace a DIY lib with an external one and id always ask “show me the commit we need.” Dont update for the sake of it.

Feeling pretty swell about this mentality with all the supply chain attacks happening.

[David Sacks @DavidSacks]

Based Bezos is awesome

[OpenAI @OpenAI]

Today, we share a breakthrough on the planar unit distance problem, a famous open question first posed by Paul Erdős in 1946.

For nearly 80 years, mathematicians believed the best possible solutions looked roughly like square grids.

An OpenAI model has now disproved that belief, discovering an entirely new family of constructions that performs better.

This marks the first time AI has autonomously solved a prominent open problem central to a field of mathematics.

[Kekius @kekius9]

"Don't try to directly seek money or happiness. Focus on creating tangible value and contributing more to society than you take. The rewards will come naturally." — Elon Musk

[Marc Lou @marclou]

@deckard_the_dev I used to

And that ended up killing my productivity because context switching is the bottleneck

[Google @Google]

Gemini 3.5 Flash is built to help you execute complex, agentic workflows.

3.5 Flash rivals flagship models to deliver frontier performance for agents and coding, at the lightning speeds you expect from the Flash series.

[himanshu @himanshustwts]

i still think about an incredible combination of both.

sam was right for that particular timeline (2019) but you can pull off many many things now and it is rewarding ngl.

[@levelsio @levelsio]

If Claude Code keeps being slow like this while I pay $200/mo (and they don't let me pay more)

They will essentially force me to leave to Codex and I don't want to

But it's soooooo slooooooooooooowwwww

[Erin Price-Wright @espricewright]

If you're a naturally anxious person, I recommend pursuing a high stress career path where at least you'll be compensated for anxiety you're going to have anyways.

[Maziyar PANAHI @MaziyarPanahi]

GPT-5.5 + OpenMed Agent planning a 64-step clinical workflow.

Watch plans, sub-plans, and tool calls materialize, every step visible, every finalization gated.

Medical intelligence on @huggingface.

The loop is the product.

[🍜 @cprkrn]

HOLY FUCKING SHIT OMG CLAUDE JUST CRACKED THIS SHIT, THANK YOU @AnthropicAI THANK YOU @DarioAmodei NAMING MY KID AFTER YOU 😍

https://t.co/gObNirRDpS

[Aaron Levie @levie]

Forward deployed engineers, or equivalent, are about to become one of the most in-demand jobs in tech. And one of the most important functions for AI rollouts.

Deploying agents is far more technical of a task than most people realize, often far more involved than deploying software. Software generally works the same way every time, and generally for the past few decades has been updated versions of an existing technology or concept (which basically means easier for the enterprise to update their workflows on a newer system).

With agents, you’re actually deploying the equivalent of work output within the enterprise. The customer is effectively using you as a professional services provider for a task, which they expect to get solved nearly end-to-end now. This means you need to actually deeply understand the business process as a vendor, and get the customer from the current to the end state seamlessly.

Companies need help figuring out which models will work best for their workflows, they need extensive evals setup often, they need change management support for workflows, they need to get their data setup for the agents, and constant tuning of the agentic system for their process.

Massive role in tech now. And another example of the kind of highly technical work that AI is creating.

[Bryan Johnson @bryan_johnson]

This is it.
Everything learned spending millions on longevity.

From: Your Immortal Unc and Auntie.
To: Our Immortal nieces and nephews.

0. Sleep is the world's most powerful drug.
1. Be in your bed for 8 hours
2. Same bedtime every night, any time before midnight
3. Don’t eat right before bed
4. Calm foods for dinner
5. No screens 1 hour before bed
6. Avoid added sugar (be aware it’s in everything)
7. Avoid all things in an American convenience store
8. Avoid fried foods
9. Shoes off at the door
10. Eat whole foods, particularly veggies fruits nuts legumes berries
11. Walk a little after meals or air squats
12. Get your heart rate high routinely
13. Lift heavy things
14. Stretch daily
15. Water pik, floss, brush, tongue scrape, morning and night
16. Make an effort to drink water
17. Get sunlight when you wake up (UV is low)
18. Protect skin in midday sun
19. Stand up straight
20. See at least one friend once a week
21. Avoid plastic where you can (in all things)
22. Circulate air in rooms
23. When stressed, breathe, learn to calm your body
24. Go to the dentist
25. Avoid sitting for long times
26. Protect your hearing, the world is too loud
27. Alcohol is bad for you
28. Finish coffee before noon
29. Avoid bright lights after sunset
30. If obese, look into a GLP
31. Sleep in a cold room
32. Texting while driving is dangerous
33. Turn off all notifications
34. Limit social media use
35. Don’t smoke anything
36. If you struggle to sleep, read a physical book before bed
37. 1 hour before bed have a calm wind down routine: bath, read, light walk, listen to music
38. The body is a clock and loves routine. Have a daily morning and evening schedule.
39. Avoid long distance travel where you can
40. Baby steps first: incorporate new things slowly
41. Do less… most things don’t work.

Bonus points if you get your blood checked.

Start here, it will change your life.

[Low Level @LowLevelTweets]

nah im just not gonna run npm install anymore

[Jay Yang @Jayyanginspires]

Co-founder and CEO of Stripe’s advice to ambitious people:

[Justin Welsh @thejustinwelsh]

A simple life hack:

Make decisions that the status quo would call unreasonable. Leave stable jobs you hate. Say no to that promotion you don't want. Walk away from money that comes with strings attached.

Great lives are built on unreasonable choices, not common ones.

[Wisdom Stoics @WisdomStoics]

take the risk.

[Nivi @nivi]

I don’t believe in a permanent underclass, but a whole new layer of high-agency people are being activated by AI.