Anders J. Skanderup

Computational cancer genomics

[Elizabeth McKenna @ElizSMcKenna]

✨Highlighting a @CD_AACR Special Issue Commentary for #AACR24: Precision Endpoints for Contemporary Precision Oncology Trials - by Regina Hoo, @drkevin_chua_lm, @pankajpanda86, @anders_js, & @danieltanmd https://t.co/t9vEM2bvty

[Roel Verhaak @roelverhaak]

Really clever approach to help understand the impact of broad copy number changes: Cancer aneuploidies are shaped primarily by effects on tumour fitness https://t.co/ivUKKcKDU6

[Debora Marks @deboramarks]

Can AI help predict pancreatic cancer earlier? https://t.co/2MYkUw1Jbc and https://t.co/5etHrsYkmY

[Chris Sander aka cscbio @sandercbio]

Go cBioPortal ! Lots of new features for easy analytic access to cancer genomics, proteomics and more. Make your own discoveries on community-provided cancer data and analysis tools.

[Communications Biology @CommsBio]

PUREE is a weakly supervised machine learning algorithm that can accurately infer tumor purity from bulk tumor gene expression data: https://t.co/2oTVZbzDCe @anders_js, @RevkovEgor

[Charles Swanton @CharlesSwanton]

Today our important study on air pollutants in the promotion of lung cancer has been published in @Nature led by @WillHilliam @LimEmilia @DrClareWeeden @SwantonLab ...Thread below🧵https://t.co/q1ICykmVox

[Shyam Prabhakar Lab @shyam_lab]

#Fluoxetine (#Prozac) changes so many genes in so many brain regions. Mechanism(s) of action are dizzyingly complex, but some promising themes emerge👇. Long-term collab with @meaneylab et al. Large integrative omics study heroically led by @braincrank_nr. @astar_gis #depression

[A*STAR Genome Institute of Singapore (A*STAR GIS) @astar_gis]

Singapore scientists develop AI-based method to identify cancer mutations https://t.co/uOEOShTqKY

[A*STAR Genome Institute of Singapore (A*STAR GIS) @astar_gis]

To update the classification system for #colorectal #cancer, the team analysed 373,000 #singlecells from 141 #tumour samples collected frm 63 patients in SG, BE, S KR.
Read: https://t.co/odi4RB2Vg1

[A*STAR Genome Institute of Singapore (A*STAR GIS) @astar_gis]

1 of the deadliest cancers with diverse etiological factors worldwide. We found unprecedented genomic diff. segregating distinctively across ethnicities & stressed the importance of differential disease biology & management in HCC across ethnicities.

https://t.co/urG7WXcqVg

[Niranjan Nagarajan @NiranjanTW]

Our recent preprint trying to explore the tricky question of “blood microbiome”! Great work by an amazing intern in the lab @cedriccstan guided by @minghao_chia https://t.co/ZnY3dGFns2

[Nature Communications @NatureComms]

VarNet, a weakly supervised #deeplearning model for somatic #VariantCalling in cancer that does not require human-engineered features or heuristic filters

#CancerResearch by @anders_js @kiran__chari et al.

https://t.co/5zWdwOPn1p

[Nature Genetics @NatureGenet]

‼️ OUT TODAY @NatureGenet
📰 Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer
��🏿‍🤝‍🧑🏼 @iaintan_mdphd @shyam_lab @astar_gis and colleagues
👇🏿
https://t.co/zhvwCeKeGl

[Anders J. Skanderup @anders_js]

Excited to share our new study and resource on tumor metabolism with @rohatgineha @astar_gis. Using tumor transcriptome deconvolution, we identify metabolic differences of cancer and stromal cells inside tumors. Some expected and unexpected findings ... https://t.co/PP80Qrj41B

[Roel Verhaak @roelverhaak]

Those signatures that were reported in that amazing 18k WGS analysis paper in Science yesterday? They can all be browsed on the amazing Signal resource portal! https://t.co/dUch3H9alQ. 😎

[Roel Verhaak @roelverhaak]

Effective drug combinations in breast, colon and pancreatic cancer cells. 2025 drug combinations vs 125 cancer cell lines 😮https://t.co/M7VWb9hVei

[Roel Verhaak @roelverhaak]

Wonderful portal that enables exploration of the phenomenal Hartwig metastatic cancer WGS/RNAseq cohort.

[Chris Sander aka cscbio @sandercbio]

Collaboration with Sjoerd van Hagen, Sander Rodenburg and Elena Garcia Lara @TheHyveNL and Augustin Luna @canninl - more to come as CPTAC enters its next phase. Go proteomics in cancer profiling!

[Daniel Tan @danieltanmd]

Excited that our paper is online! Highlights how pervasive lineage transition occurs at a transcriptomic level in T790M neg resistance, suggesting the potential for tissue-based integrative analysis to forecast resistance trajectories in EGFR M+ NSCLC. https://t.co/OBUF8vXdoU

[Nature Communications @NatureComms]

New paper by @anders_js @GuanhuaPeterZhu @astar_gis shows that nucleosome-dependent degradation and 6 regulatory regions are predictive of #circulating #tumour #DNA burden throughout #cancer #progression

#CancerResearch @NatResCancer

https://t.co/ZxUGRd5AsX