Ang Cui, Ph.D.

[Ang Cui, Ph.D. @AngCuiPhD]

✨#ImmuneDictionary✨is out today in @Nature!

Paper https://t.co/XY47lyphjU
Software https://t.co/duoWWcBmTj

We created scRNA-seq dictionary of 17+ immune cell types responding to 86 cytokines in vivo, discovered the immune system is far more complex than previously known 1/

[Ang Cui, Ph.D. @AngCuiPhD]

My lab was very happy to present our latest work at #AAI2025 @ImmunologyAAI in Honolulu, Hawaii! Exciting scientific exchanges with colleagues truly dedicated to driving immunology & immunotherapy research forward.

[Ang Cui, Ph.D. @AngCuiPhD]

Happy to share our publication on a single-cell atlas of human liver immune (myeloid) cells in #HCVCure in the @JHepatology !

A tribute to one of the most remarkable medical breakthroughs of modern times: the #HCVCure. Since the introduction of direct-acting antivirals in 2011, hepatitis C virus (#HCV) infection has become the first chronic viral infection to be curable, with newer generation antivirals achieving a >95% success rate within just 8-12 weeks of treatment.

What lessons can we learn from this success?

Paper: https://t.co/uEYvI2EEAO
Editorial: https://t.co/pT6s39cwx5

As part of a Phase 3b open-label clinical trial, we used single-cell genomics to systematically profile myeloid cells in the livers of individuals with HCV before and after viral clearance. We identified cell populations with immunoregulatory potential during active infections: ISG-high neutrophils and eosinophils were found to upregulate PD-L1 and IDO1, respectively, and proliferating dendritic cells increased post-cure. Further, we identified a correlation between pre-treatment viral load and the post-cure host immune state. We hope the data will inspire the development of immunotherapeutic strategies for other infections that currently lack a cure.

Acknowledging our incredible team for making this work possible @nalatrak, #BoLi, @raychungmd, #NirHacohen, #MichaelWallace, #AnnaGonye, #ChrisOetheimer, #HaileyPatel, @PierreTonnerre, #GeorgLauer, and many others.
@broadinstitute @MGHMedicine @harvardmed #HCV #Liver #Infections #ImmuneCells #SingleCell #DirectActingAntivirals #DAAs

[Edward Chuong @edchuong]

I’m excited to share our latest study led by
@GiuliaPasquesi out today in @CellPressNews , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵

[Michael Fischbach @mfgrp]

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55

[ICIS 🦋 @cytokinesociety.bsky.social @CytokineSociety]

Congratulations to 2023 ICIS YI Award winner recognized as one of the 35 innovators under 35 worldwide by MIT Technology Review!!!

[Ang Cui, Ph.D. @AngCuiPhD]

@CytokineSociety Thank you @CytokineSociety !

[Ang Cui, Ph.D. @AngCuiPhD]

Congratulations Professor Hinton for winning the 2024 Nobel Prize in Physics!

Big day for #AI #ML

[University of Toronto @UofT]

#UofT Professor Emeritus Geoffrey Hinton has won the 2024 Nobel Prize for Physics.

Hinton shares the prize with John J. Hopfield “for foundational discoveries and inventions that enable machine learning with artificial neural networks.” #NobelPrize https://t.co/NkWyAwi3eZ

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

[Alex Chudnovskiy 🇺🇦 @ChudnovskiyLab]

I am happy to share a large part of my postdoctoral work published in @SciImmunology! Using LIPSTIC, we identify and characterize antigen-presenting dendritic cells (DCs) in the tumor-draining lymph node and tumor microenvironment
https://t.co/Xdv7cxYegr

[Waggoner Lab @LabWaggoner]

DCs that present antigen to tumor-specific CD4+ T cells in the tumor and tumor-draining lymph node @SciImmunology @victora_lab
https://t.co/2Wp6zCQYFe

[Ivan Zanoni @Lo_Zanzi]

#SameSameButDifferent! Chudnovskiy @victora_lab &co use #LIPSTIC @SciImmunology to show that only a fraction of DCs interact & activate T cells in the tumor draining lymph node & tumor microenvironment & found IL-27 potentiate anti-tumor T cell responses! https://t.co/IVjm9BhGOg

[Dr. Jean Fan @JEFworks]

Check out our updated #bioRxiv preprint on #bionformatics #Rstats method CRAWDAD (Cell-type Relationship Analysis Workflow Done Across Distances) for quantifying cell-type spatial relationships in #spatialomics data

📰: https://t.co/UMF2d3hetL
💻: https://t.co/132Ug6VQ2Z

[Ang Cui, Ph.D. @AngCuiPhD]

@lindaunobel Thank you! @lindaunobel

[Lindau Nobel Laureate Meetings @lindaunobel]

Congratulations to our Lindau Alumna 2023!😃Ang Cui also participated in one of our #LINO23 Panel Discussions https://t.co/RZ7f0VaV4j

[Ang Cui, Ph.D. @AngCuiPhD]

@QuinaScience Sounds like a plan!

[Ang Cui, Ph.D. @AngCuiPhD]

@QuinaScience Congratulations on this exciting milestone!!

[Ang Cui, Ph.D. @AngCuiPhD]

@jimmykoppel Thank you!!

[Ang Cui, Ph.D. @AngCuiPhD]

I am thrilled to have been selected by MIT Technology Review @techreview as one of the 35 Innovators Under 35 worldwide! #ImmuneDictionary #CytokinesPower #TR35 #biotech
https://t.co/fWxjt4BhDl

[ImmPort @ImmPortDB]

THANK YOU to the ImmPort Big Data in Immunology speakers @NimaAghaeepour, @Reuben6Sarwal, @AngCuiPhD, Dr. Mattew Altman, & organizer @Sanchitab for sharing your research, resources, & AI-ready data sets! Find ImmPort’s free data & resources here https://t.co/taui5hv3hq
#FOCiS2024

[Immunology Podcast @ImmunoPodcast]

Introducing: an immune dictionary! 📘

@AngCuiPhD and a team at the @BroadInstitute created a #scRNAseq dictionary of 17+ immune cell types responding to 86 cytokines in vivo.

📎 @Nature paper: https://t.co/QQ7zt8M2rN
🎙️ Episode: https://t.co/IQOpI6DSkf