Angela Yu

Tackling RNA regulation and structure with computation and experiments.

[Angela Yu @angelamyu]

Pleased to present R2D2 (Reconstructing RNA Dynamics from Data) which was published today in @MolecularCell! Massive thank you to ALL of the co-authors and the amazing people in the @LucksLab. I still can't believe my rotation project led to this! Check out this thread:

[The Lucks Lab @LucksLab]

Introducing R2D2 (Reconstructing RNA Dynamics from Data) - a new tool to make movies of cotranscriptional RNA folding pathways published in @MolecularCell from @NorthwesternU, @NUSynBio, and @OhioState https://t.co/gKpo27Fbqe (1/10)

[Lukas Oesinghaus @LOesinghaus]

Just put my first postdoc publication on bioRxiv – designing cell type-specific gene and mRNA therapy from microRNA expression data! Good timing with the recent Nobel Prize, I guess. In essence: You have to use the right type of expression data. https://t.co/ZQlh2FK7IZ

[Angela Yu @angelamyu]

@n_rose_d @CUAnschutz Congratulations!!

[Angela Yu @angelamyu]

@elisew00 Congratulations, that's awesome!

[Angela Yu @angelamyu]

Super happy to have contributed to this team effort! Yet another example of the structural and functional consequences of a single nucleotide change in #RNA. The importance of the wobble pair here is striking. Great work team and especially first author @Laura_M_Hertz!

[LauR(N)A M. Hertz @Laura_M_Hertz]

The first part of my PhD thesis is officially online @NAR_Open!!! So thankful for the collaborations that added so much, from this movie of RNA structure dynamics to showing that RNA can function at 65 °C!!! I will now forever be obsessed with wobble bp and single nt changes

[Liang Liu @Liang_Liu_]

Excited to share my most recent work in @NatureSMB on mRNA 3' processing and the anticancer compound JTE-607: https://t.co/E4eDDazLCD. A huge thank you to my PI @YongshengShi, my collaborators @angelamyu and @seeliglab, and amazing lab mates @YoseopYoon @LVSoles and @mariiellee1

[Angela Yu @angelamyu]

@BiochemPhD @NatureSMB @jjohlin @seeliglab @YongshengShi Thanks! You are correct 🤖

[Angela Yu @angelamyu]

Happy to see our paper on the anti-cancer compound JTE-607 effects on mRNA 3' processing come out in @NatureSMB! Unraveling more drug-RNA processing questions. Congratulations to all my co-authors, including Liang Liu, @jjohlin, @seeliglab, and @YongshengShi!!

[Yongsheng Shi @YongshengShi]

I'm glad that our paper on the anticancer compound JTE-607 has come out in 2023 in @NatureSMB ! Congrats to first authors Liang Liu and @angelamyu
https://t.co/UZ7hn7qKqH

[Angela Yu @angelamyu]

@BiochemPhD Thanks, Khalid!

[Angela Yu @angelamyu]

Very happy to have contributed to this effort. Congratulations, team! Unearthing more of the intricacies of RNA and ligand binding.

[The Lucks Lab @LucksLab]

Preprint alert! "The Effect of Pseudoknot Base Pairing on Cotranscriptional Structural Switching of the Fluoride Riboswitch" in @biorxivpreprint by @Laura_M_Hertz @elisew00 @angelamyu et al.

https://t.co/RVvw8HQBHc

Lots of cool data (including transcribing RNA at 65 °C!)

[Angela Yu @angelamyu]

Having a blast meeting #RNA23 @jrRNAscientists!! We made an RNAbow with our buttons! @rawatravans @CoanMichela @TinaUroda

[Angela Yu @angelamyu]

Excellent collaboration with @YongshengShi, Liang Liu, @jjohlin, and @seeliglab on sequence specificity of the anti-cancer compound JTE-607! Our ML model, Cleavage and Counteraction with Compound 2 on Polyadenylation Outcomes (C3PO), captures polyA sites' JTE-607 sensitivity. 🤖

[Yongsheng Shi @YongshengShi]

New preprint from our lab and a great collaboration with @seeliglab !

The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3' processing machinery https://t.co/audwUX6ZI2

[Angela Yu @angelamyu]

@seeliglab @YongshengShi I second this!

[Angela Yu @angelamyu]

@cam_glasscock @LucksLab ^I take partial credit. Biomolecule separation and detection. Safety shower and ELISA too!

[Angela Yu @angelamyu]

@ParseBio at #ASHG2022. Fantastic talk on their technologies and their updated Evercode v2 kit and applications by @CharlieRoco

[Angela Yu @angelamyu]

Grateful for the opportunity to talk about our exon skipping MPRA in multiple cell lines this morning! This has been an exciting group effort in the @seeliglab! @SamanthaKoplik, Yue Zhang, @CharlieRoco, @dna_rosenberg, @nbogard, Madelyn Shelby, Alex Sabo. #ASHG2022

[Elfride De Baere @elfridedebaere]

Excellent session on Massively Parallel Variant Characterization with nice talks from @angelamyu (splicing) @LaylaSiraj (regulation) @MoezDawood (PALB2 missense) #ASHG22 #VUS

[Angela Yu @angelamyu]

Check out the latest collaboration between @LucksLab and the Chen lab (@TheRNAInstitute) and led by @luyi_cheng and @elisew00! Nothing better than #RNA functional + structural characterization and simulations! Happy to have helped out with this effort and see R2D2 in action.

[The Lucks Lab @LucksLab]

Announcing our latest BREAKTHROUGH ARTICLE in @NAR_Open from @luyi_cheng (@NorthwesternEng @NorthwesternU) @elisew00 @angelamyu and Chen Lab (@TheRNAInstitute) featuring one of our favorite RNA molecules: riboswitches! https://t.co/aMIY9tpciq (Volume on for the soundtrack). 1/

[The Lucks Lab @LucksLab]

New #RNA folding paper up on @biorxiv! Led by @luyi_cheng (@IBiSatNU) w/ @elisew00 @angelamyu, ChenLab @TheRNAInstitute, we show how strand exchange is involved in riboswitch folding. Feat some SHAPE-Seq, flow cytometry, and gorgeous MD simulations!

https://t.co/0WrWKfUzQr

[Angela Yu @angelamyu]

@WeillCornellGS Thank you!

[Angela Yu @angelamyu]

@cbm_student @NIHDirector @NIHFunding @WeillCornellGS Thank you!

[Angela Yu @angelamyu]

Honored to have our R2D2 work and #RNA folding featured in the @NIHDirector blog today!

The @NIHFunding we received helped make it happen. I am particularly grateful for the T32 training grant that supported me during my time as a @WeillCornellGS @cbm_student!

[The Lucks Lab @LucksLab]

We are not the only ones who love RNA folding. Latest blog post from @NIHDirector Francis Collins on our R2D2 work with @angelamyu and Chen Lab: @NorthwesternU @NorthwesternEng @TheRNAInstitute
https://t.co/Rf48rPFgKE