Ángeles Tepper, PhD

🇨🇱 PhD Neuroscience (PUC) 🇬🇧 WIN Global Scholar (Univ of Oxford) 🇺🇲 Visiting scholar at CONNplexity Lab (Purdue University) 🇦🇷 Bioengineer (UNER)

[Barbi Corvalan 💚 @BarbiCorvalan]

Que necesario este contenido. Hay que viralizarlo

[VULGA @vulgarcite]

Este experimento es una genialidad.
4 niños intentan hacer funcionar aparatos analógicos.

[Oded Rechavi @OdedRechavi]

when it's your turn to give lab meeting and you don't have new results to show

[Luiz Pessoa @PessoaBrain]

𝗜𝗻𝘁𝗲𝗿𝗲𝘀𝘁𝗲𝗱 𝗶𝗻 𝗶𝗻𝘁𝗲𝗿𝘀𝗲𝗰𝘁𝗶𝗼𝗻 𝗼𝗳 𝗰𝗼𝗻𝗰𝗲𝗽𝘁𝘂𝗮𝗹 & 𝗲𝗺𝗽𝗶𝗿𝗶𝗰𝗮𝗹 𝗯𝗿𝗮𝗶𝗻 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵?
Some of this year's discussions in Neurosci & Philosophy Salon:
Brain networks
Consciousness
Causation
Emergence
Mental disorders
https://t.co/QjpquHFDHA

[Nicholas Fabiano, MD @NTFabiano]

This is 1 cubic millimeter of the brain.

57,000 cells, 150 million synapses & 230 millimeters of ultrafine veins.

[Ángeles Tepper, PhD @angietepp]

NEW PAPER OUT 🥳 (it's open access)

⭐Longitudinal changes in striatocortical connectivity in first-episode psychosis associated with the emergence of treatment resistance⭐

See the summary figure for more info, or read the full article at:
https://t.co/VVB1LCVkCx

[Oxford Centre for Integrative Neuroimaging @OxfordCIN]

Registration is still open for #FSLCourse2025. Register now to secure your spot!

💻 Fully online course
🗓️ September 15th-26th
🧠 Lectures & practicals on structural, functional, diffusion and resting state brain image analysis
🔗 https://t.co/glliv7yHaX

[The OpEd Project @TheOpEdProject]

We are in a war of ideas for the future of our nation and our democracy. This is about all of us, but it is not only about us; it is also about those we lift up. So right now, we encourage you to think of whose voices you believe in, that we need to hear from in this moment, if we want to build a democracy and the world we want to live in – we urge you to send them to one of our “Write to Change the World” workshops. It is open to everyone, regardless of identity, position, or means. We seek to over-represent the underrepresented, and scholarships are available for anyone who needs them.

Upcoming workshops:
👉🏾 July 16 & 17 (2:00 pm - 5:30 pm ET)
👉🏾 July 24 & 25 (10:00 am - 1:30 pm ET)

Register here: https://t.co/nEZmIrTmwe

[Oxford Centre for Integrative Neuroimaging @OxfordCIN]

Time is ticking! Applications for the 🌍 OxCIN Global Scholars Programme 🌍close on June 30th.

Are you an early career researcher from the Global South, interested in online training in MRI physics & analysis using FSL? Apply here: https://t.co/Q7l0Soi995

Please repost!

[Eric Topol @EricTopol]

How exercise protects the brain through neurovascular-associated astrocytes and neuroplasticity:
Results of elegant single cell/nuceli studies in the experimental Alzheimer's model @NatureNeuro
https://t.co/3f8sCT51DC

[Michael Okun @MichaelOkun]

BREAKING: Your brain’s connective tissue isn’t just glue: It’s a switchboard for neuromodulation. We used to think that astrocytes (the beautiful star-shaped glial cells) were the brain’s 'support staff.' But thanks to exciting new work from Guttenplan and colleagues this week in Science, we have more evidence that glia are more than just passive observers. They are active gatekeepers, controlling how brain circuits turn on and off in response to neuromodulators like dopamine, norepinephrine, and glutamate not to mention 'electricity.'
Key Points:
- The gating is driven by GPCR signaling and internal cell state, not just calcium.
- G protein–coupled receptor (GPCR) activity in astrocytes, especially via the dopamine D2 receptor (Dop2R), changes how these cells regulate circuits.
- Dopamine responses can be flipped from inhibitory to excitatory via astrocyte control.
- Astrocytes can reverse how neurons react to dopamine, dramatically changing behavior in animal models.
- These mechanisms are ancient and conserved across species.
- From fruit flies to rats, astrocytes play this surprising regulatory role meaning human relevance is likely high.
- Glia may hold the key to improving neuromodulation therapies.
- By targeting astrocyte gating mechanisms, we might one day use this to fine-tune DBS or pharmacological treatments more precisely and effectively.
- The bottom line? Glia are emerging as not just as glue, but as circuit integrators.
- Glia could be the secret to unlocking smarter, more personalized neuromodulation.
My take: This isn’t just basic science, it’s a potential game changer for how we think about treating Parkinson’s, depression, epilepsy, and beyond. If astrocytes can 'gate' neuron responses, then targeting glia may be the next frontier in brain modulation therapies like deep brain stimulation (DBS), focused ultrasound, or even neuropharmacology. Glial cells, especially astrocytes, aren’t just background noise; they dynamically shape how neurons behave. This study uncovers a 'gating' mechanism, where one neurotransmitter can flip a switch in astrocytes that changes how they respond to other astrocytes and the surrounding brain tissue. The findings are conserved across species: flies, zebrafish, and mammals. This data collectively suggests that incredibly this process likely has a fundamental role in brain evolution and function. Astrocytes are not passive. They actively decide how and when neurons fire. Exposure to neuromodulators like norepinephrine could potentially unlock how the astrocyte respond to other transmitters such as dopamine and glutamate.
#GliaMatters #Astrocytes #Neuromodulation #Parkinsons #Neuroscience #DBS #BrainHealth
https://t.co/6VedYGyKLa @ParkinsonDotOrg @FixelInstitute

[Aristotle Voineskos @AVoineskos]

While evidence is increasing that psychedelics offer some benefit, we don’t need to relearn the lessons of the past in relation to psychosis risk. A precision health approach is needed. And what’s almost certain is that these are not for teenagers with developing brains.

[Shruti @heyshrutimishra]

MIT University just released free online courses.

No payment required.

Here are 10 courses you don't want to miss in 2024:

[Chenxin Li, PhD (@chenxinli2.bsky.social) @ChenxinLi2]

@chorye I have an illustrated repository called “friends don’t let friends make bad graphs”. https://t.co/KeSsEcrvOk

Comes with counter-examples, examples, and explanations.

[Dr. Glaucomflecken @DGlaucomflecken]

Elsevier is losing editors

[Ángeles Tepper, PhD @angietepp]

Gender inequality is associated with differences between brains of men and women.

Study with 7876 fMRI scans from 29 countries.

👏👏

https://t.co/yGAzMuNDKI

[Ángeles Tepper, PhD @angietepp]

👏👏👏

[Imaging Neuroscience @ImagingNeurosci]

All NeuroImage and NeuroImage:Reports editors have resigned over the high publication fee, and are starting a new non-profit journal

https://t.co/DmnwDKVCK7

This comes with great regret, and a huge amount of thought and discussion- please read announcement to get more details.

[Matthew Betts, Ph.D. @MTJBetts]

PhDs have a range of transferable skills but are not taught how to market them.

Here are 10 high-value transferable skills:

[Joaquín Goñi @jgonicor]

Intra and inter-individual variability in functional connectomes of patients with First Episode of Psychosis. Great work led by @angietepp (visiting scholar at CONNplexity Lab during 2020/21). With Dr. Nicolas Crossley and team. https://t.co/9IDAdZVUmZ

[Javi López ⛩️ @javilop]

La AI está cambiando el mundo, pero la mayoría no sabe cómo comenzar a utilizarla en su día a día.

He estado varios meses buscando las MEJORES herramientas de IA para que tú no tengas que hacerlo.

¡Vamos allá!

10 aplicaciones de IA para hacerte la vida MUCHO más fácil 🧵👇