US - California: CDPH statement - 3rd #H5N1 confirmed human case confirmed by the CDC. + 2 more possible cases identified with CDC tests pending. All are animal contact, mild symptoms. https://t.co/tYjbx7kZVz h/t Commonground
@jbloom_lab What is the effect of S323 on HA stability? Looks suspiciously close to the fusion peptide and several other mutations well described to affect stability.
Doses of an experimental #Marburg vaccine — designed at the @NIH's Vaccine Research Center & being developed by @sabinvaccine — arrived in Rwanda on Saturday where a clinical trial will soon get underway. Photo: Sabin Institute https://t.co/QblwMkTDF1
@mvankerkhove of @WHO urging for evidence driven policy, equitable access to safe and effective vaccines, building Pandemic Influenza Preparedness (PIP) strategy, and platforms to facilitate sharing of key reagents
An important study by F. Eun-Hyung Lee's team shows that long lived plasma cells (the source of long-term circulating antibodies) fail to establish after mRNA vaccination (even combined with SARS-CoV-2 infection). 🧵 (1/)
https://t.co/Z15xiyxCLS
Amazing, quick work! Would like to hear what is happening in NA/2SBS also. A160T restores a glycosylation site that could affect HA:NA balance e.g. https://t.co/HLDjg7rjsA
Here is analysis of HA mutations in H5 influenza case in Missouri resident without known contact w animals or raw milk.
TLDR: there is one HA mutation that strongly affects antigenicity, and another that merits some further study.
CDC confirmed a human case of H5 bird flu in Missouri in a person who has fully recovered. This is the 14th case in the United States in 2024. An investigation into the potential exposure is ongoing, but the public risk assessment remains low at this time. Read more: https://t.co/yzwencYOZx
Why are some people volunteering to be infected with diseases?
Dr @anikasinga from @ImperialInfect shares preliminary insights and findings on the SARS-CoV-2 human challenge study with @BBCNews#COVID19
https://t.co/h2lkl5USNy
Clinicians detail H5N1 infections in 2 Michigan farm workers
One patient had conjunctivitis in one eye, and the other had longer lasting flulike symptoms.
https://t.co/RZ2tDHYJML
MSC has published its findings on the 2023 clinical academic survey, revealing an ageing workforce and continuing gender and ethnic imbalances in clinical academia.
Press release: https://t.co/1937d0UN4R
Interactive tool: https://t.co/RoV1VpfSKN
3rd US #H5N1#birdflu case, this one with respiratory symptoms. Farm worker in Michigan who wasn't wearing PPE. Said to be recovering. https://t.co/NdS5cBRyFg
Agree with all of this - great article in @NatureMedicine - "Why diversity is needed at every level of clinical trials, from participants to leaders"
https://t.co/ZoZC9PNTRJ
To further protect the U.S. livestock industry from the threat posed by highly pathogenic H5N1 avian influenza, @USDA is sharing a number of actions that we are taking with our federal partners to help us get ahead of this disease and limit its spread. https://t.co/c1t2TdfTyE