Dr. Ana Nikolic

MD/PhD. Assistant professor, U of Calgary DPLM. Neuropathologist. PI. 🧠❤️, brain tumor research nerd and part-time bioinformagician. she/her

[My Neuropath News @NeuropathClinic]

Tempered Optimism: Advances in the Precision Medicine Era for Pediatric Low-Grade Glioma
https://t.co/gxtDcDvHt2

[Parmita Mishra @parmita]

A beautiful paper

[Michael 英泉 Eisen @mbeisen]

How do you publish this tree and claim it's a success???!!!

[Dr. Ana Nikolic @anniekey]

Great points here, emphasizing the various degrees of cognitive engagement with AI/LLM use.

[Brian D. Earp, Ph.D. @briandavidearp]

"Writing is thinking." This phrase went viral recently (from https://t.co/4GDZHnm82U), often quoted in the context of objections to use of AI in drafting academic prose. In Nature Reviews Bioengineering we respond: "Thinking is not only writing." Preview below. Shareable full access link: https://t.co/ktHuPFcPga

[Sounak Gupta @Shounak_Gupta]

We have performed germline MLH1 hypermethylation testing for Lynch syndrome in >400 individuals. Using long read sequencing, we have identified MLH1 promoter mutations associated with Constitutional MLH1 promoter hypermethylation in one of the largest studies to date!

[Cell Genomics @CellGenomics]

Hi-C for genome-wide detection of enhancer-hijacking rearrangements in routine lymphoid cancer biopsies https://t.co/aVaVWQl8yV

[NEJM @NEJM]

Presented at #ASGCT2026:

A neuroepithelial tumor occurred in a child who had previously received AAV gene therapy for mucopolysaccharidosis type I. Analysis of tumor tissue showed the integration of rearranged AAV vector elements in the gene PLAG1. Read the full report: https://t.co/M8dzK6UeER

@ASGCTherapy

[Salim S. Hayek, MD @salimhayek]

Physician-scientist pipeline is a retention problem, not a recruitment problem. We lose people in years 5–6 when revisions stack and RVUs absorb protected time. This month's JCI editorial names the connective tissue departments don't fund. https://t.co/DqHaZ7kNZU

[nature @Nature]

Nature research paper: Synthetic super-enhancers enable precision viral immunotherapy

https://t.co/7vmCeFSTkO

[Stephen Turner 🦋 @stephenturner.us @strnr]

PLOS Biology: Formalizing our commitment to code sharing https://t.co/q3cztdw6HP

[Aparna Bhaduri @BhaduriLab]

(1/5) How does glioblastoma maintain its immense heterogeneity? 🧠 Two new companion papers from the Bhaduri Lab @UCLA now on @bioRxiv offer a lineage-resolved view of GBM hierarchies. Let’s dive in! 🧵👇

https://t.co/ss3FWXWakN
https://t.co/DFRqbeEttO

[Jamie Blundell @jrblundell]

In 1999, Tom Maniatis discovered something remarkable: neurons achieve self-avoidance via stochastic methylation of the protocadherin gene cluster.

We've just discovered this locus is an evolvable in-vivo barcode across the human tissues: https://t.co/DMyHA5TIS0 🧵

[Stephen Turner 🦋 @stephenturner.us @strnr]

Ten simple rules for teaching data science https://t.co/2Skk5ObXOv

1: Teach data science by doing data analysis
2: Use participatory live coding
3: Give tons of practice and timely feedback
4: Use tractable or toy data examples
5: Use real and rich, but accessible data sets

[Dr. Ana Nikolic @anniekey]

This is devastating news - Mike was a kind and generous human and classmate and incredibly talented clinician.

[Matt Burke @MattBurkeMD]

It is so painful to share the news of @FralickMike sudden and unexpected passing 💔

Mike was an amazing, inspiring and generous person who touched the lives of many.

As we mourn, please share and consider supporting his wife and 2-year-old daughter. https://t.co/uErWWCFPde

[Dr. Ana Nikolic @anniekey]

@sarthak_s @HotchkissBrain @UCalgary @jeffbiernaskie Congrats!

[Xuebing Wu @wu_xuebing]

Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element https://t.co/MynOLLNvXi

[Anshul Kundaje @anshulkundaje]

The @ENCODE_NIH Phase 4 Registry of candidate cis regulatory elements (ccREs) (2.37 million human and 967,000 mouse cCREs) is officially out

https://t.co/uuJAsO334Z

https://t.co/wtCW3beYlv

Congrats to @MooreJillE
@ZhipingWeng & everyone else.

Lots more incoming ...

[Denis Wirtz @deniswirtz]

What method should you use to track migrating cells?

Read "Methods to analyze cell migration data: fundamentals and practical guidelines" to find the best cell tracking tool.

Download the paper here: https://t.co/3qGrW9OACg

[Luca Pinello @lucapinello]

🎉 Our systematic benchmark of spatially variable gene detection methods is out in @GenomeBiology!
https://t.co/yvJpFkPu3j
We compared major methods so you don't have to. Hope this helps guide your spatial analysis or inspire better methods!
Huge congrats to the amazing team 🙌

[Tony Kwan @DrTonyKwan]

Get your abstracts in by Friday if you want to be eligible for a talk!

We also have many poster prizes that we award and the abstracts also need to be submitted by Friday. The poster sessions are always exciting and buzzing with energy!