Maria SOKOLOVA

Lise Meitner Research Group Leader @MPI_Biochem since March 2024
Bacteriophages

[NatureStructMolBiol @NatureSMB]

New online! Host transfer RNA guides assembly of viral RNA polymerase https://t.co/wzht1SFJTu

[Cell @CellCellPress]

Now online! mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity https://t.co/xkjftU5vFs

[NatureStructMolBiol @NatureSMB]

New online! Promoter proximal pausing of RNA polymerase across evolution https://t.co/rgDqVAImDI

[Cell Biology J-Club @cell_club]

Mitochondria directly interact with the nuclear pore complex | Nature https://t.co/x9YeBPQ9kE

[Rafa Pinilla-Redondo @rafapinilla92]

Phages invented sgRNAs before humans!!

Obviously, for mischief… 😈

Loved seeing this story unfold!
https://t.co/bRrxAHpgPG

[Christine Mayr @Mayr_Christine]

Finally out in @Cellcellpress!
Proteins with long intrinsically disordered regions (IDRs) are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
https://t.co/Pa4bWYhOMe

[Science Magazine @ScienceMagazine]

Key human defenses against pathogens were forged billions of years ago in microbial battles with viruses.

Learn more: https://t.co/NqwQk38nzX @NewsfromScience

[Sergey Ovchinnikov @sokrypton]

ESMfold2, includes support for protein-protein interactions, DNA/RNA, small molecules. Including colab notebook!
https://t.co/kivCKw9AxL

[Vivek Mutalik @vivek_mutalik]

🔔 New Preprint 🎉 from https://t.co/22jmPoaXR8
🥳 Super excited to share our work on generating systematic 95 phage-99 MDR P. aeruginosa strain interaction dataset & use of ML to predict phage susceptibility & phage cocktails from target genome sequences alone, w validations.

[Rob Lavigne @RobLavigne1]

Check out our latest contribution: How a Patient’s Voice inspired our development of implementing phage therapy for Hidradenitis Suppurativa patients https://t.co/sMXFjB0Xlz via @LinkedIn

[Andre Cornman @ancornman1]

Predicting protein-protein interactions (PPIs) at proteome scale can take months with co-folding models due to massive all-vs-all comparisons required.

We are excited to announce FlashPPI, a contrastive model that predicts proteome wide physical interfaces in minutes. 1/🧵

[Jianan Zhao | Graph/LLM/AI4S | Postdoc Spring ’27 @AndyJiananZhao]

📢 RaftPPI @ ICLR 2026: proteome-scale protein–protein interaction retrieval with residue-level fidelity. For N proteins of average length L, exhaustive scoring costs O(N²L²). We approximate this with per-protein embeddings + ANN search → GPU months → GPU/CPU minutes. 1/4 🧵

[Jordy F. Botello @JordyBotello]

Some molecular machines, like ribosomes, persist for long periods in cells

Could molecular aging of ribosomes shape how proteins are made?

In our preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10)

https://t.co/kT2WTUN7T9

[Vivek Mutalik @vivek_mutalik]

Excited to share this review🔔, we spent sometime thinking about
phage–microbiome–immune–oncology axis for phage therapy in cancer!
#phage
Phage therapy in oncology: opportunities for cancer prevention and treatment: Trends in Molecular Medicine https://t.co/rxn8RCCU1p

[Kotaro Kiga @KotaroKiga]

Very excited to share our new paper! Homing endonuclease SegB drives segmental amplification of anti-defense loci, enabling phages to escape multiple bacterial defense systems.
https://t.co/fxHCmBmYoL
Big thanks to Kotaro Chihara and to the Vasili lab.

[Nature Reviews Microbiology @NatureRevMicro]

New online! Phage host range: determinants, dynamics and applications https://t.co/NWaShIVE70

[Nature Microbiology @NatureMicrobiol]

Nuclease–NTPase antiphage defence systems use conserved molecular features to control bacterial immunity https://t.co/pGgCKIUeHD #MicroSky

[hnisimasu @hnisimasu]

な・・・何を言っているのかわからねーと思うが・・・Scienceに論文を書いていたら、Scienceに論文が出た・・・DRTの恐ろしさの片鱗を味わったぜ・・・
https://t.co/K2cIuJg362
https://t.co/CqlMRQFaby

[Joe Bondy-Denomy @joeBondyDenomy]

Phage community: our plasmids for executing phage transposon mutagenesis are now on AddGene and I would love for you to try it out! It is powerful for ID'ing all essential genes and knocking out all non-essentials in a single experiment :) New exp here:
https://t.co/rLtpaXWXR6