Arohan Subramanya

Physician-Scientist at the University of Pittsburgh.
K+ 🥑🍌 |🧂&💧| WNKs 😉 | Crowding 🔆 | Condensate Physiology 🎇
🦋

[Arohan Subramanya @arohan_s]

Our latest, now in print in @jclinicalinvest (w/ cover! 🎉) Led by @caryboyd3, we identified a functional role for #WNK bodies in K+ homeostasis, highlighting a #condensate 🫧 that can influence kidney physiology & nephron sexual dimorphism, w/ implications for human health 1/

[Eric Weinhandl @eric_weinhandl]

Adjusted rate of ESKD incidence in the US, as seen in the new USRDS ADR. Hang it in the Louvre.

[Arohan Subramanya @arohan_s]

Was great to catch up with my
@CWRUSOM brother- the amazing @UChiPritzker pulmonologist and bronchoscopist extraordinaire @kylehogarth last weekend in Chicago. Pretty sure this guy can scope a bronchiole if he so chooses…

[Arohan Subramanya @arohan_s]

@Zimmermk1986 @jclinicalinvest @caryboyd3 Thank you!

[Arohan Subramanya @arohan_s]

Our latest, now in print in @jclinicalinvest (w/ cover! 🎉) Led by @caryboyd3, we identified a functional role for #WNK bodies in K+ homeostasis, highlighting a #condensate 🫧 that can influence kidney physiology & nephron sexual dimorphism, w/ implications for human health 1/

[Arohan Subramanya @arohan_s]

@OsamaHarraz @staruschenko @caryboyd3 Thanks so much!

[Arohan Subramanya @arohan_s]

@staruschenko @caryboyd3 Thank you Sasha!

[Cary Boyd-Shiwarski, MD/PhD @caryboyd3]

🧵1/
WNK bodies are biomolecular condensates in action—membraneless compartments that enable rapid, spatially organized control of NaCl transport based on dietary potassium. A new paradigm in renal signaling and homeostasis. 🧠🧪Here’s the story👇
#WNKbodies #RenalPhysiology

[Arohan Subramanya @arohan_s]

@GdC_CCCB_lab @jclinicalinvest @caryboyd3 It is! Thanks so much

[Arohan Subramanya @arohan_s]

@AlanYuNeph @jclinicalinvest @caryboyd3 Thanks Alan!

[Arohan Subramanya @arohan_s]

@Vishal_D_Patel @jclinicalinvest @caryboyd3 Thanks so much Vishal! And congrats re: your own accomplishments of late!

[Arohan Subramanya @arohan_s]

Thank you! @pittkidneyctr was essential for this project

[Univ of Pitt Center for Kidney Research @pittkidneyctr]

As always, @arohan_s & @caryboyd3 have cutting edge research so stunning you’d think you were standing in an art gallery!

Keep WNK-ing, you two!

@PittDeptofMed @PittTweet @PittMedMag @tkleyman @RodTan07 @ManishaJhambMD @PAmarapurkar @RayRenal @ShiwarskiLab

[Arohan Subramanya @arohan_s]

@CBI_Pitt Thanks Simon, Jon, and Mara! Look forward to continuing our collaboration! @pittkidneyctr

[Arohan Subramanya @arohan_s]

Love the tagline!

[Journal of Clinical Investigation @jclinicalinvest]

A nod and a wink to kidney-specific WNK1

This issue’s cover features work by Cary R. Boyd-Shiwarski et al. @caryboyd3 on kidney-specific WNK1 as a scaffolding protein that organizes WNK bodies — structures essential for maintaining blood potassium levels: https://t.co/1Z9qurlWXT

[Arohan Subramanya @arohan_s]

@GermanRick95 @jclinicalinvest @caryboyd3 Thank you @GermanRick95 ! Congrats on your recent study as well

[Arohan Subramanya @arohan_s]

@gerardo_gamba @jclinicalinvest @caryboyd3 Nice editorial indeed… thanks Gerardo!

[Arohan Subramanya @arohan_s]

Congrats to Cary Boyd-Shiwarski @caryboyd3 , who expertly saw this through as corresponding author, lab members & alums incl Becca Beacham & @Kate_Querry; and to our collabs incl @okashlan @CBI_Pitt @ShiwarskiLab Aylin Rodan @UofUNephrology Chou-Long Huang & Sean Stocker 🎉🥳/12

[Arohan Subramanya @arohan_s]

More generally, this work extends beyond functional studies in cells to support the relevance of biomolecular #condensates in mammalian #physiology, while hinting @ intriguing connections between condensates & public health. 11/