Our latest, now in print in @jclinicalinvest (w/ cover! ๐) Led by @caryboyd3, we identified a functional role for #WNK bodies in K+ homeostasis, highlighting a #condensate ๐ซง that can influence kidney physiology & nephron sexual dimorphism, w/ implications for human health 1/
Was great to catch up with my
@CWRUSOM brother- the amazing @UChiPritzker pulmonologist and bronchoscopist extraordinaire @kylehogarth last weekend in Chicago. Pretty sure this guy can scope a bronchiole if he so choosesโฆ
Our latest, now in print in @jclinicalinvest (w/ cover! ๐) Led by @caryboyd3, we identified a functional role for #WNK bodies in K+ homeostasis, highlighting a #condensate ๐ซง that can influence kidney physiology & nephron sexual dimorphism, w/ implications for human health 1/
๐งต1/
WNK bodies are biomolecular condensates in actionโmembraneless compartments that enable rapid, spatially organized control of NaCl transport based on dietary potassium. A new paradigm in renal signaling and homeostasis. ๐ง ๐งชHereโs the story๐
#WNKbodies#RenalPhysiology
A nod and a wink to kidney-specific WNK1
This issueโs cover features work by Cary R. Boyd-Shiwarski et al. @caryboyd3 on kidney-specific WNK1 as a scaffolding protein that organizes WNK bodies โ structures essential for maintaining blood potassium levels: https://t.co/1Z9qurlWXT
Congrats to Cary Boyd-Shiwarski @caryboyd3 , who expertly saw this through as corresponding author, lab members & alums incl Becca Beacham & @Kate_Querry; and to our collabs incl @okashlan@CBI_Pitt@ShiwarskiLab Aylin Rodan @UofUNephrology Chou-Long Huang & Sean Stocker ๐๐ฅณ/12
More generally, this work extends beyond functional studies in cells to support the relevance of biomolecular #condensates in mammalian #physiology, while hinting @ intriguing connections between condensates & public health. 11/