Arpan Samuel Ramtek

🎯 Product @leadsquared | Specialty Coffee Enthusiast | Formerly, Product @plazatweets @Nowfloats @exotel @DigitalDeshin

[Arpan Samuel Ramtek @arpanramtek]

@soaibgrewal @aakrit @177pc Congratulations 🥂

[TheLiverDoc™ @theliverdoc]

Coffee is one of the only drinks with strong evidence that benefits the liver. Here's what decades of research actually says about how to drink it right:

Coffee genuinely lowers liver disease risk.
Meta-analyses show regular drinkers have about 35% lower risk of significant liver fibrosis and nearly 50% lower risk of liver cancer compared with non-drinkers.

Aim for 2–3 cups a day, minimum.
The effect is dose-dependent. The Hepatology socities such as AASLD and EASL says 3 or more cups daily is reasonable for liver benefit, if you tolerate it.

Caffeinated works better than decaf.
But decaf still helps.
Caffeine blocks adenosine receptors that drive liver scarring. Decaf lowers chronic liver disease risk too, just by a smaller margin (UK Biobank, n=494,585).

The target dose: ~300 mg caffeine/day, or 3 cups.
Fibrosis protection kicks in around the 75th percentile of intake, roughly 308 mg caffeine, or 2.25 cup equivalents, per day - the AASLD 2023 advises 3+ cups for liver benefit.

What a "cup" actually means
One standard cup = 240 ml (8 oz), not a 60 ml tiny Indian "cup." A 240 ml filter coffee has ~95–165 mg caffeine. A single espresso shot (30 ml) has only ~60–75 mg.

Coffee-to-water ratio: 1:15 to 1:17.
For filter/drip/pour-over: 15 g of ground coffee to 250 ml water. This is the standard brewing ratio and gives clean extraction of chlorogenic acids and caffeine.

Choose medium roast, not dark.
Medium roast has significantly higher chlorogenic acid (CGAs) content than dark roast. Dark roasting thermally degrades CGAs, the main antioxidant doing liver work.

Arabica beats Robusta.
Arabica beans are richer in CGAs and polyphenols, the antioxidants doing most of the liver-protective work.

A note here:
Arabica for polyphenols, Robusta for caffeine.
Arabica (1.5% caffeine) has more CGAs and polyphenols. Robusta (2.7% caffeine) has more caffeine but a cruder phenolic profile. A 70:30 Arabica-Robusta blend is a reasonable compromise.

Water temperature: 92–96°C.
Just off a rolling boil. Too hot (>96°C) burns the grounds and extracts bitter compounds; too cool (<90°C) under-extracts CGAs and caffeine.

Grind size matters.
Medium grind (table-salt texture) for filter/drip. Coarse for French press. Fine for espresso. Brew time: 3–4 minutes for pour-over, 4 minutes for French press, 25–30 seconds for espresso.

Filtered coffee is the safest daily choice.
Paper filters trap cafestol and kahweol, naturally present plant diterpenes that raise LDL cholesterol if consumed daily in large amounts. Pour-over (V60, Kalita, Melitta) or drip machines with paper filters give you CGAs and caffeine without the cholesterol penalty.

Espresso and French press: fine, but not unlimited.
They retain more polyphenols but also more diterpenes (so more chances of increased lipids). Great occasionally; don't make them your 5-cups-a-day default if you have high cholesterol or heart disease.

South Indian filter coffee: acceptable, with caveats. The metal filter does not remove diterpenes as well as paper, so limit to 1–2 cups/day if you have dyslipidemia. The decoction itself is rich in CGAs. Use less sugar. Skip condensed milk.

BUT ULTIMATE: Drink it black. Or close to it.
Sugar, syrups, flavored creamers and whipped cream cancel the liver benefit, especially if you already have fatty liver, diabetes, or obesity. Skim milk or unsweetened plant milk is fine.

Instant coffee: still works.
UK Biobank (n=494,585) showed instant coffee drinkers had similar reductions in chronic liver disease as ground coffee drinkers. Not as potent, but far better than no coffee.

Cold brew: underrated for the liver.
Medium roast + coarse grind + 6–7 hours at room temperature extracts CGAs and caffeine efficiently with lower bitterness. pH and CGA content are comparable to hot brew.

Timing.
Spread across the day. one at breakfast, one mid-morning, one early afternoon. Stop by 2 pm if you have insomnia.

It helps across almost every major liver disease.
Evidence supports benefit in fatty liver (MASLD), alcohol-related liver disease, hepatitis B and C, cirrhosis, and liver cancer.

The mechanism isn't magic, it's chemistry.
Chlorogenic acid cuts oxidative stress and liver fat. Caffeine inhibits stellate cell activation (that promotes scarring or fibrosis). Melanoidins and polyphenols reduce inflammation.

Who should go easy.
Pregnancy, children, those with uncontrolled heart rate and rhythmn issues (arrhythmias), panic disorder, or insomnia.

And no, coffee does not undo a bad diet or bad choice - such as alcohol, herbal supplement or that Ayurvedic "liver tonic."

Sources: Modi et al., Hepatology 2010; Kennedy et al., BMC Public Health 2021 (UK Biobank); Fuller & Rao, Sci Rep 2017; AASLD MASLD Clinical Care Pathway 2023; EASL 2016 CPG, Frontiers in Nutrition 2026 (Italian coffee cohort).

[Arpan Samuel Ramtek @arpanramtek]

@lightroastguy About 0.2%

[Arpan Samuel Ramtek @arpanramtek]

Manipal Signal :-/

[Paarug Sethi @paarugsethi]

sony signal is bangalore’s strait of hormuz

[Essential @essential]

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[Arpan Samuel Ramtek @arpanramtek]

@mehulved @wanderingraptor @lightroastguy @sahilk @thipaiah_ Indonesia has such good normal coffee in Jakarta as well as Bali. There is one traceable wild luwak seller https://t.co/UnTlW6wSw1

[Claude @claudeai]

Introducing Cowork: Claude Code for the rest of your work.

Cowork lets you complete non-technical tasks much like how developers use Claude Code.

[Arpan Samuel Ramtek @arpanramtek]

So, Bengaluru Tunnel gets approved. 👀
Also, this is a Moscow Metro Map from 2018

[Arpan Samuel Ramtek @arpanramtek]

@surivinam @pratikpoddar Go to Nerlu (Indiranagar or crescent road) and try the new roaster they have this month. Its called Hill Groove Coffee Roasters.

The Stanmore is the one I recommend. You can buy a 250gm bag of coffee from them, the baristas can grind it as well.

[Soaib Grewal @soaibgrewal]

This makes me nostalgic. cc @arpanramtek

[Arpan Samuel Ramtek @arpanramtek]

@soaibgrewal This is is, right there!

[Arpan Samuel Ramtek @arpanramtek]

@lightroastguy Do it, Do it!

[Arpan Samuel Ramtek @arpanramtek]

@an5rag hey! share your favs as well

[Arpan Samuel Ramtek @arpanramtek]

Version 2 of the 🗺️ Map of Independent Coffee forward cafés of Bengaluru incoming ☕️

[Arpan Samuel Ramtek @arpanramtek]

Happy to report that @BlueTokaiCoffee ‘s NanoX ‘25 is a floral bomb with lots of sweetness as it cools down. No wonder it sold out in 20mins.

It’s a Carbonic Macerated (Process) Brown Tip Gesha (cultivar) grown in Yercaud, India

[Arpan Samuel Ramtek @arpanramtek]

It’s been a couple of months since our first print of the Coffee Forward Cafes in Bengaluru.

It took me about 3 years to visit these cafes and it has expanded even further.

Bengaluru Coffee Shops · Arpan
https://t.co/WvTBs9SpiC

Feedback / Suggestions?
DM me. Thanks

[Lavanya. @lavanyasureka]

This is so cute and available at Nerlu … more people should be talking about this

[Arpan Samuel Ramtek @arpanramtek]

@mehulved @lavanyasureka @footofresh Thanks Mehul! Glad you like it @lavanyasureka

[miten sampat @miten]

"are you doing your life's work?"

great question to ask every once in a while

[Vardhman Jain @lightroastguy]

Note to founders: If you are raising money , do try and raise from strategic investors. It would give you immense confidence on reduction on COGS/Scaling up business/Solving supply chain.

( We raised from a coffee estate and it's helping us with sourcing at a phenomenal price)

[Arpan Samuel Ramtek @arpanramtek]

@neilparikh @RadicalVentures @ForerunnerVC @a16z @felicis @trailmixvc @joinsequel Congrats @neilparikh will def check and share feedback