Ashwin Narain

Postdoc @genentech, PhD, MS 🧬👨‍🔬🧫 @Uni_WUE, BTech 👨‍🎓 @warangal_nit

Cancer Dependency, TPD, PROTACs, NGS, Microscopy, Proteomics, CRISPR, RNAPII,

[Ashwin Narain @ashwin_narain]

Grateful for my amazing lab mates' support, my advisor's guidance, and everyone who believed in me! Couldn't have done it without you all! A big shout-out to my lab mates for the awesome #PhDHat, summarizing my journey from TSS to PAS (PhD Achievement Site). #PhDone 🎓🙌👨‍🎓

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Congratulations to @ashwin_narain for delivering an outstanding doctoral defense!!! 🎉

[FragileNucleosome @FNucleosome]

The recordings of last week's fantastic seminars from @ashwin_narain & @ErcanLab lab are now online!

https://t.co/bBHriiGhWA

https://t.co/lUg2yZmGkm

[Ashwin Narain @ashwin_narain]

@chrstn_e @ErcanLab Thanks for the opportunity to present my work at @FNucleosome seminars. Was a great learning experience.

[Ben Martin @bmart87]

Topoisomerases, condensin, and Spt6! This #FragileNucleosome seminar is going to be great! Join us tomorrow at noon EDT to hear the latest from @ErcanLab and @ashwin_narain! Register here: https://t.co/qe3aSV0OyA

[Matteo Perino @MatteoPerino_]

Don't miss tomorrow session! Transcription elongation/termination and topoisomerase/condensin with @ErcanLab and @ashwin_narain

[Sebastian M. Markert @sci_bastian]

Marble machine as an intuitive mechanical model of nerve signal propagation.

If you like it, please share. I hope to get enough views so it becomes eligible for the big @veritasium contest :)

https://t.co/rYPpmGecvr

[analytica @analyticaFair]

Most-read analytica news: Obstacles on the racetrack of life 🧬 New picture of the transcription
https://t.co/tahKoCWvi0
@_BikashAdhikari
#analysis #biology #MolecularBiology #biochemistry #genetics #mRNA
📸 Sandy Westermann

[Seychelle Vos @seyvos]

We are looking for a research technician to join our young and dynamic lab. We have lots of interesting projects and are looking for someone who wants to spend a couple years with us. https://t.co/p854s2MpI7 Please RT!

[GRK2243 @grk2243]

Congratulations to another amazing story from @_WolfLab
#sciencetwitter #Science

[Ashwin Narain @ashwin_narain]

@SHAZEBAHMAD8 @_WolfLab @PranjScripts @Pol2Runner @erhard_lab @MolecularCell Thanks @SHAZEBAHMAD8 🍾

[Pranjali Bhandare @PranjScripts]

Thrilled to see my co-first authored research in the wonderful blue hue of @MolecularCell ! 😁 Have a look in here to get to know this superhero of a protein - SPT6!
https://t.co/NS6iv4LGXT

[Ashwin Narain @ashwin_narain]

Great to see my co-first author paper with @PranjScripts online....
Special thanks to @Pol2Runner @_BikashAdhikari
Danke! to @_WolfLab for the great journey from a Master student @GSLSUniWue to publishing my co-first author paper...and next up #PhD...🎓

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Happy to share the latest study from our lab, led by @Pranjscripts @ashwin_narain @Pol2Runner in collaboration with @erhard_lab, now out in @MolecularCell !! Using #TPD #genomics #proteomics and #MathematicalModeling, we found dual roles of SPT6 in #transcription 🧵

[Apoorva Baluapuri @Pol2Runner]

Super excited to have the first paper out as a corresponding author !! Was fun working with @_WolfLab, particularly @PranjScripts @ashwin_narain @_BikashAdhikari. Learnt loads from collaboration with @erhard_lab @DolkenL @MYCGyvers - and fantastic support from @FNucleosome !!

[Ashwin Narain @ashwin_narain]

Thanks a lot to the team @PranjScripts @Pol2Runner @_BikashAdhikari
@_WolfLab
@erhard_lab
@MYCGyvers
@DolkenL
Prof. Schlosser @RVZ_Wuerzburg for the contributions, the editor and the reviewers for a critical but considerate review process.
P.S. Article is #openaccess
...6/6

[Ashwin Narain @ashwin_narain]

Excited to share the details of our story on #histone chaperone SPT6 and its direct role in #transcription studied using #TPD #genomics and #proteomics @MolecularCell.
We found SPT6 not only has a role in RNAPII processivity but also influences RNAPII termination globally
🧵

[Molecular Cell @MolecularCell]

Online Now: Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination https://t.co/CnQCvYqLU2

[Ashwin Narain @ashwin_narain]

We propose kinetically distinct roles of SPT6,
1) it maintains RNAPII processivity by aiding #nucleosome passage of RNAPII, and long-term absence of this activity leads to #epigenetic chaos,
2) SPT6 is vital for successful transcription termination by regulating 3’ pausing...5/6