Aastha Singh

Postdoc @VAInstitute👩‍🔬
PhD @HelsinkiUni🗡
In a love-hate relationship with #alphaSynuclein and #ParkinsonsDisease 🧠
Baker in-the-baking🍰, a doggo-lover😍

[Aastha Singh @asingh2310]

@HND_Lab is recruiting! 🚨

Great opportunity for #postdocs interested in neuroscience, molecular mechanisms, translational models, and therapeutic development.

Share with anyone who may be interested!

#hiring #postdoc #synuclein #tau #parkinson #alzheimer

[Michael Henderson @MXHend]

We’re hiring a Postdoc in the Henderson Lab @ Van Andel Institute!

Join our team studying neurodegenerative disease across scales (molecular → circuits). Flexible, high-impact projects and strong mentorship.

Apply: https://t.co/QJFXnmLiIy

Please share!

[Eric Topol @EricTopol]

AI to understand the language of life.
Our review @NatureBiotech just published
https://t.co/i0WMaXBCHl
Free access https://t.co/3LPulNxlD0
@VishRao5 @serena2z @BrianPlosky @pdhsu @BoWang87 @james_y_zou @marinkazitnik @pranavrajpurkar

[Van Andel Institute (VAI) @VAInstitute]

Congratulations to Dr. J. Timothy Greenamyre, recipient of the 2025 Jay Van Andel Award for Outstanding Achievement in Parkinson’s Disease Research! Dr. Greenamyre received the award today at the Grand Challenges in Parkinson's Disease symposium: https://t.co/pyX2lzXe5N

[Aastha Singh @asingh2310]

@HND_Lab Looks fun!
And what a sweet bunch of people!! 👀

[HND_Lab @HND_Lab]

Had another great summer party! Celebrating 5 years!

[Michael Okun @MichaelOkun]

Boom! Cerebrospinal fluid (CSF) flow extends to peripheral nerves. Alexander Ligocki, Ed Scott and colleagues @UF @UFHealth blow our minds. New paper @ScienceAdvances. What will we call it now? Cerebro-spinal-nerve fluid (CSNF)? or maybe brain-spinal-nerve fluid (BSN)? Just when you think you have a few ground truths of the brain and nervous system, you are humbled again.
Key Points:
- The authors point out that dogma holds that cerebrospinal fluid is responsible for 'maintaining brain homeostasis through nutrient delivery and waste removal for only the central nervous system.'
- They show extensive CSF flow throughout the peripheral nervous system.
- They traced multimodal 1.9-nanometer gold nanoparticles.
- These nanoparticles were roughly the size of CSF circulating proteins.
- They squirted them into the lateral cerebral ventricle.
-They showed incredibly that the particles transitioned from central to peripheral nervous systems at root attachments and transition zones.
- They showed the particles could make it all the way to the axoplasm of distal peripheral nerves.
- Bigger 15-nanometer gold particles were not able to make the journey.
My take: We know that the nervous system does not contain the more traditional lymphatics and has a force field called the blood brain barrier. We know that CSF delivers nutrients and removes waste from the brain and central nervous system. Our previous ground truth was established by studies using dye tracers. Using small gold nanoparticles these authors 'tore down the dogma.' So the real question is whether it is time for a name change? Cerebrospinal fluid (CSF) or cerebro-spinal-nerve fluid (CSNF)? or maybe brain-spinal-nerve fluid (BSN)? Thoughts? Sartor resartus – the tailor re-tailored our view on this important aspect of neuroscience. BRAVO!
https://t.co/63yeOGTaru #parkinson #CSF #cerebrospinal #Alzheimers

[Aastha Singh @asingh2310]

@ScienceofPD @CureParkinsonsT @wembleystadium @Safak_Er_ go get it!!!😍

[Aastha Singh @asingh2310]

@amydjohn Yes, tbh once you acknowledge everyone who should be acknowledged, that's more than enough. It'll be beautiful no matter what!

I wish you good luck with the writing! 🥰

[Aastha Singh @asingh2310]

Indeed, thesis acknowledgments are love letters.. just a tad professional. ❤️

Check out this beautiful compilation of PhD students' emotional rollercoaster in black and white..

#PhD #AcademicChatter

https://t.co/YDczvfWDvR

[Aastha Singh @asingh2310]

Defended my PhD @helsinkiuni #ftdk a couple of days ago 🎓 and today, made my way to the Nobel Prize Museum 😎

I think I'm doing okay.. pretty much on the right track! 😉

@LabVoutilainen ❤️
#PhDone 🗡️
#WhatsNext 🫣
#nojinxies 🧿

[Aastha Singh @asingh2310]

@Safak_Er_ @ucl @BiochemSoc Deal! 😎

[Aastha Singh @asingh2310]

@Safak_Er_ @ucl @BiochemSoc 😭 without meee!

I wish you a super fun and productive conference!😎 And ofc, enjoy Crete! 😍

[Jari Yli-Kauhaluoma @JYK_Viikki]

🦉#PhDDefense at #FTDK! @asingh2310 June 14, noon, Aud. 1041, BK2, Viikink. 5, “Optimization of alpha-synuclein-based models of PD...” All welcome! #pharmacy #viikkicampus @lifescihelsinki @helsinkiuni
📽️live stream: https://t.co/Na7BRmAV3f
📗thesis book: https://t.co/A1dxiBjRJv

[Eric Topol @EricTopol]

There's never been a disease-modifying drug for Parkinson's disease to slow its progression. Now there may be two emerging.
—GLP-1
https://t.co/CMerh986a1 @NEJM
—anti-synuclein antibody https://t.co/3DRvOabAKv
@NatureMed

[Jari Yli-Kauhaluoma @JYK_Viikki]

The Viikki Chemistree 2023🌲
Happy Xmas!
#FTDK #pharmacy #Biocenter2 #chemistree #Xmas #ViikkiCampus @LifeSciHelsinki @helsinkiuni

[Aastha Singh @asingh2310]

OUT NOW!

Based on our last work, you asked if we have tested the combination of @alpha_synuclein PFFs and 6-OHDA in animals.

Presenting to you, PFF+6-OHDA in mice, along with the effect of #CDNF in these animals.

Excited about this one!

@LabVoutilainen @EJNeuroscience

[The Science of Parkinson's @ScienceofPD]

New research from @asingh2310 @MerjaVoutilain5 & colleagues reports that cerebral dopamine neurotrophic factor (CDNF) rescues to some extent a 6OHDA model of #Parkinsons, but not the combination of 6-OHDA + alpha synuclein preformed fibrils
https://t.co/Fzarn3mZNN

[Aastha Singh @asingh2310]

📢 Happening now!

Proud and/or possessive, you decide!

See you at Board J10. Looking forward to exciting discussions and possible collaborations!

11th November 2023

@SfNtweets
#SfN23 #alphasynuclein #Parkinsons

[Aastha Singh @asingh2310]

‼️Novel mouse model of #PD

Presenting some freshly brewed data on..
"Combination of alpha-synuclein PFFs and 6-OHDA to develop a mouse model of #Parkinsons disease"

When: 11th Nov, 1 pm - 5pm

Board: J10

If you don't find me around, dm me!

@SfNtweets #SfN23

[Aastha Singh @asingh2310]

Obsessed!
SIA singing in Punjabi is such a vibe!✨

While doing some #GFAP analysis, playing on loop today.. Hass Hass🎶💕

[sia @Sia]

If you're my ocean, I'm your wave 🎶🌊 "Hass Hass" with @diljitdosanjh and Sia is out now! https://t.co/NUFnRJ5N5r - Team Sia

[video description: clips from the "Hass Hass" music video with a cartoon of Sia and Diljit dancing with a woman and admiring fireworks]