Postdoc @VAInstitute👩🔬
PhD @HelsinkiUni🗡
In a love-hate relationship with #alphaSynuclein and #ParkinsonsDisease 🧠
Baker in-the-baking🍰, a doggo-lover😍
We’re hiring a Postdoc in the Henderson Lab @ Van Andel Institute!
Join our team studying neurodegenerative disease across scales (molecular → circuits). Flexible, high-impact projects and strong mentorship.
Apply: https://t.co/QJFXnmLiIy
Please share!
Congratulations to Dr. J. Timothy Greenamyre, recipient of the 2025 Jay Van Andel Award for Outstanding Achievement in Parkinson’s Disease Research! Dr. Greenamyre received the award today at the Grand Challenges in Parkinson's Disease symposium: https://t.co/pyX2lzXe5N
Boom! Cerebrospinal fluid (CSF) flow extends to peripheral nerves. Alexander Ligocki, Ed Scott and colleagues @UF@UFHealth blow our minds. New paper @ScienceAdvances. What will we call it now? Cerebro-spinal-nerve fluid (CSNF)? or maybe brain-spinal-nerve fluid (BSN)? Just when you think you have a few ground truths of the brain and nervous system, you are humbled again.
Key Points:
- The authors point out that dogma holds that cerebrospinal fluid is responsible for 'maintaining brain homeostasis through nutrient delivery and waste removal for only the central nervous system.'
- They show extensive CSF flow throughout the peripheral nervous system.
- They traced multimodal 1.9-nanometer gold nanoparticles.
- These nanoparticles were roughly the size of CSF circulating proteins.
- They squirted them into the lateral cerebral ventricle.
-They showed incredibly that the particles transitioned from central to peripheral nervous systems at root attachments and transition zones.
- They showed the particles could make it all the way to the axoplasm of distal peripheral nerves.
- Bigger 15-nanometer gold particles were not able to make the journey.
My take: We know that the nervous system does not contain the more traditional lymphatics and has a force field called the blood brain barrier. We know that CSF delivers nutrients and removes waste from the brain and central nervous system. Our previous ground truth was established by studies using dye tracers. Using small gold nanoparticles these authors 'tore down the dogma.' So the real question is whether it is time for a name change? Cerebrospinal fluid (CSF) or cerebro-spinal-nerve fluid (CSNF)? or maybe brain-spinal-nerve fluid (BSN)? Thoughts? Sartor resartus – the tailor re-tailored our view on this important aspect of neuroscience. BRAVO!
https://t.co/63yeOGTaru #parkinson #CSF #cerebrospinal #Alzheimers
@amydjohn Yes, tbh once you acknowledge everyone who should be acknowledged, that's more than enough. It'll be beautiful no matter what!
I wish you good luck with the writing! 🥰
Indeed, thesis acknowledgments are love letters.. just a tad professional. ❤️
Check out this beautiful compilation of PhD students' emotional rollercoaster in black and white..
#PhD#AcademicChatter
https://t.co/YDczvfWDvR
There's never been a disease-modifying drug for Parkinson's disease to slow its progression. Now there may be two emerging.
—GLP-1
https://t.co/CMerh986a1 @NEJM
—anti-synuclein antibody https://t.co/3DRvOabAKv
@NatureMed
OUT NOW!
Based on our last work, you asked if we have tested the combination of @alpha_synuclein PFFs and 6-OHDA in animals.
Presenting to you, PFF+6-OHDA in mice, along with the effect of #CDNF in these animals.
Excited about this one!
@LabVoutilainen@EJNeuroscience
New research from @asingh2310@MerjaVoutilain5 & colleagues reports that cerebral dopamine neurotrophic factor (CDNF) rescues to some extent a 6OHDA model of #Parkinsons, but not the combination of 6-OHDA + alpha synuclein preformed fibrils
https://t.co/Fzarn3mZNN
📢 Happening now!
Proud and/or possessive, you decide!
See you at Board J10. Looking forward to exciting discussions and possible collaborations!
11th November 2023
@SfNtweets#SfN23#alphasynuclein#Parkinsons
‼️Novel mouse model of #PD
Presenting some freshly brewed data on..
"Combination of alpha-synuclein PFFs and 6-OHDA to develop a mouse model of #Parkinsons disease"
When: 11th Nov, 1 pm - 5pm
Board: J10
If you don't find me around, dm me!
@SfNtweets#SfN23
If you're my ocean, I'm your wave 🎶🌊 "Hass Hass" with @diljitdosanjh and Sia is out now! https://t.co/NUFnRJ5N5r - Team Sia
[video description: clips from the "Hass Hass" music video with a cartoon of Sia and Diljit dancing with a woman and admiring fireworks]