A.Taguchi

PI - @UOsaka_en @cider_pr
PhD - @HarvardMicro @BBS_Harvard

[A.Taguchi @at_taguchi]

Happy to share our work characterizing a novel streptococcal ABC transporter that exports the antibiotic fosfomycin, now published in @PNASNews! https://t.co/DiatpOEgUv

[Yuan @Yuanqiao1002]

Special Issue on “Microbiota, Infections and Host Immunity” at ACS Infectious Diseases is calling for papers! Co-edited by @Yuanqiao1002 @Matt_E_Griffin and @Hatzios_Lab. Submit your work now https://t.co/KusHeL7JEp Please RT 🙏

[A.Taguchi @at_taguchi]

Happy to see our latest work on pneumococcal pyruvate kinase published in @JMolBiol! In this study, we investigated the molecular factors that make this enzyme prefer GTP synthesis over ATP synthesis https://t.co/jrygXkrppQ

[Nature Microbiology @NatureMicrobiol]

OUT NOW 👉 This marine bacterium captures peptigoflycan fragments from other cells and uses them to build its own cell wall https://t.co/AzTchVIa2c

[A.Taguchi @at_taguchi]

@davidroper2 @jbiolchem Yes, this is our working model for the fosfomycin resistance observed in our pyk mutants.

[A.Taguchi @at_taguchi]

Check out our work on pyruvate kinase in Streptococcus pneumoniae, now available @jbiolchem!

[Journal of Biological Chemistry @jbiolchem]

New in JBC press: "Scientists' work sheds light on the regulatory mechanism of SpPYK and lays the groundwork for antibiotic development that targets this essential enzyme."
Learn more:
https://t.co/Nq0m4rsjYI

[Bailey Schultz @bjschul7]

So excited to share this work from the Walker Lab, now online @NatureMicrobiol (https://t.co/XPtMfjzCeC), in which we uncover a general strategy for bacterial cell envelope polymer acylation using teichoic acid ᴅ-alanylation as a paradigm!

A 🧵 below for anyone interested:

[A.Taguchi @at_taguchi]

Our work on peptidoglycan polymerase inhibitor screening is now online @angew_chem!

[Angewandte Chemie @angew_chem]

A Time-Resolved FRET Assay Identifies a Small Molecule that Inhibits the Essential Bacterial Cell Wall Polymerase FtsW (Suzanne Walker and co-workers) @HarvardMicro @HarvardCCB https://t.co/pVhAEsfTHG

[Nature Microbiology @NatureMicrobiol]

OUT NOW @Nature

👀Coordination of bacterial cell wall and outer membrane biosynthesis

https://t.co/XJxBqyZaS5

[ASM @ASMicrobiology]

New in #JBacteriology! A minireview exploring peptidoglycan glycosidases, enzymes notorious for both the diversity of their specific physiological roles & their nonspecificity for fulfilling the same role within & between bacterial species. Check it out: https://t.co/brGGJJRehg

[bioRxiv Microbiology @biorxiv_micrbio]

Candidate undecaprenyl phosphate translocases enable conditional microbial fitness and pathogenesis https://t.co/NsX6CufJOp #biorxiv_micrbio

[bioRxiv Microbiology @biorxiv_micrbio]

Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation https://t.co/m8rzZYf3Qa #biorxiv_micrbio

[A.Taguchi @at_taguchi]

An excellent @PNASNews commentary on our recent paper that investigated the functions of membrane-bound cell wall hydrolases in S. pneumoniae! https://t.co/GiQzVvg7sS

[A.Taguchi @at_taguchi]

@davidroper2 @PNASNews @IUBiology @HarvardMicro It becomes open access after 6 months, but I can provide the manuscript pdf via email/DM if you are having trouble accessing it. Also we posted a preprint on biorxiv that contains most of our findings https://t.co/MuiNUnGIPz

[A.Taguchi @at_taguchi]

Happy to see our work on S. pneumoniae peptidoglycan glycosidases in @PNASNews! A great collaboration with the Winkler lab (@IUBiology). @HarvardMicro
https://t.co/T4SdxQ5hGy

[Prof. Akiko Iwasaki @VirusesImmunity]

やっと完成しました。日本の皆様のために、mR N Aワクチンの有効性と安全性についてのビデオを作ってみました。お役に立てると嬉しいです。１日も早く、ワクチンを打って集団免疫を獲得しましょう！リツイートお願いします。

https://t.co/i50Zfsf2sm

[A.Taguchi @at_taguchi]

@microbe_megan You could try looking for an alternative company that can service your LC-MS. We did that for our Agilent LC-MS and I became less stressed about mass spec maintenance.

[Laura Kiessling @ChemicalBiology]

ACS Chemical Biology, along with the ACS Division of Biological Chemistry, is pleased to announce the recipient of the 2021 ACS Chemical Biology Lectureship Award – Suzanne Walker, PhD.

https://t.co/nFLLbNgIQU

[Dr. Cassie Joiner @cassie_joiner]

So excited that this story is finally published! 🎉 I hope you all enjoy how we found that protein substrates engage OGT’s TPR domain differently for glycosylation. @HammelForrest @jjanetzko #chemtwitter #glycotime https://t.co/0IdSN9PQEP

[PeptidoglycanPapers @GlcNAcMurNAc]

Biochemical reconstitution defines new functions for membrane-bound glycosidases in assembly of the bacterial cell wall https://t.co/baLlmWFEWO