Adina Abeles

Social scientist working on climate, criminal justice, immigration, housing. Also a mom.

[Alex Rives @alexrives]

Today we're announcing ESMFold2, an open scientific engine to power prediction, design, and discovery across protein biology.

The new model delivers state of the art performance on protein interactions, especially antibodies, a critical modality for therapeutics.

We have designed and validated miniprotein binders and single chain antibodies across five therapeutic targets that are important in cancer and immunology. We are seeing very high success rates, and affinities at levels consistent with therapeutic activity.

We’re also releasing an atlas of 6.8 billion proteins, and 1.1 billion predicted structures.

ESMFold2 is built on a state of the art language model that has been trained on billions of protein sequences.

A world model of protein biology emerges through language modeling.

We’ve used the techniques of mechanistic interpretability developed to understand large language models to understand the concepts ESM uses to represent proteins.

The model’s representation space has a compositional organization of features across scales, levels of complexity, and abstraction, that reflects and mirrors the understanding of protein biology developed through a century of empirical science.

This understanding emerges without prior knowledge, just from language modeling of protein sequences.

Language models are becoming a powerful substrate to understand and program biology.

The design of protein interactions is one of the most fundamental problems in biophysics, and has critical implications for the discovery of new medicines. A simple gradient based search with the model was able to discover high-affinity protein binders.

I'm excited by the potential this has to accelerate basic science and the understanding of proteins. And especially for the new avenues it opens up for therapeutic design and medicine.

[Adina Abeles @atabeles]

@HemaPreya @PolPsyISPP Requesting to silence research because you don’t like it normalizes bias. I think the questions asked and approach make this an important piece of research that we could all learn from.

[Adina Abeles @atabeles]

@Kaiping_Chen Yikes! Glad you are ok!

[Adina Abeles @atabeles]

@NikFeldman Done

[ADL @ADL]

ADL is announcing Campus Antisemitism Legal Line (CALL) in partnership with @HillelIntl, @brandeiscenter & @gibsondunn - a helpline for Jewish students & faculty on college campuses across the US that will help provide legal services in a climate of increasing antisemitism: https://t.co/ohq1e6dFfu

[Bari Weiss @bariweiss]

Around the world, young people are tearing down photographs of innocent Israelis abducted by Hamas. One of them is Sarah.

My Old Friend Is Ripping Down Posters of Kidnapped Children . . .

Read @cmittel5 in @TheFP:

https://t.co/28IpHAp8Ke

[ADL @ADL]

In the aftermath of Hamas's massacre of over 1,400 people in Israel, Jewish students are being assaulted, intimidated & harassed on campus. Urge your Senators to support a resolution to condemn the rise of antisemitism on college & university campuses. ➡️ https://t.co/iASYMOoMpB

[The Free Press @TheFP]

An Israeli student assaulted at Columbia.

A Jewish student’s dorm room set on fire at Drexel University.

A Stanford University professor separated students by Jews and non-Jews in class.

Our institutions of higher education are alive with hate.
https://t.co/zQz1TuKqF9

[J.K. Rowling @jk_rowling]

We said ‘never again.’ The UK was a safe haven. Now, after the biggest massacre of Jews since the holocaust, British Jewish children are being advised to hide their identities as they walk to school, for their own safety. There should be mass outrage that this is necessary.

[Adina Abeles @atabeles]

@mbfc_discussion @MontereyBayFC Such a bummer!

[The Just Trust @thejusttrust]

We don’t even have the words to describe how important and powerful this is. You’ll just have to watch…. @nytimes @VisitingRoomPr https://t.co/ESkDTmyROz

[Robb Willer @RobbWiller]

🚨🚨Come work with us!🚨🚨

I'm excited to announce that Stanford's Polarization and Social Change Lab is recruiting two new, post-doctoral positions: a Postdoctoral Scholar and a Research Scholar! See full thread below for info on both. Please share!

[Adina Abeles @atabeles]

@RobbWiller @GreggRSparkman @NatureComms @howelaurenc Lots of thoughts here. Could be that elite cues indicate no R support for any policy coupled with lessening cue for denying climate change outright.

[Carl Nasman @CarlNasman]

“It’s just summer.” 🙄 https://t.co/f03z18cMTX

[Adina Abeles @atabeles]

@JonathonSchuldt @RoperCenter @pete_enns Congrats! This is great!

[The Late Show @colbertlateshow]

Looking for ways to support the people of Ukraine? Here's how:

World Central Kitchen
https://t.co/xVdxJQ9Tln

Razom for Ukraine
https://t.co/93efmZbyWJ

Nova Ukraine
https://t.co/0B37mLRjZb

United Help Ukraine
https://t.co/4RzKuYmkFN

Global Giving
https://t.co/LLkgQE7YOF

[Adina Abeles @atabeles]

@davidmmarkowitz @PsychScience Great news! Congrats!

[Monterey Bay Aquarium @MontereyAq]

Deep-sea animals may look out of this world, but they’re not as weird as you might think! Aquarium scientists Alicia, Ellen, MacKenzie and Tommy are here to set the record straight in our latest video collaborocean with @MBARI_News! #IntoTheDeep
▶️ https://t.co/9MxSHAsjnr

[Adina Abeles @atabeles]

See this announcement on investments in people and tech. Which carbon dioxide removal technologies are you most excited about? Or skeptical about?

[Chan Zuckerberg Initiative @ChanZuckerberg]

Smart and thoughtful technology + innovation are a 🔑 part of addressing the #ClimateCrisis

That’s why we’re supporting scientists + entrepreneurs to develop + scale climate solutions 🧵⬇️ https://t.co/sUWkpTf1FR