New print🚨🚨
@nicobuchon and I just published our new review in #frontiersinimmunology
about mosquito blood feeding, the different layers of innate immunity, and the microbiota, and how they all shape vector competence..
New paper in Nature Communications 🚨
How do cells remove DNA lesion–stalled RNA Pol II?
We uncover a hierarchical clearance pathway: TFIIH first, ubiquitin/VCP backup → protects genome integrity.
🔗 https://t.co/XWRzRPvWCd
#DNArepair#RNApolII
Excited to share our new Nature study! 🧬
We (@UruciSidrit et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful co-directional clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
https://t.co/oVshI7n2Mt
Our first group method paper is out in @STARProtocols from the @bmbSDU@NATsdu, presenting a robust imaging approach to monitor de novo RNA synthesis at DNA DSBs! Huge shout-out to all co-athors and to our collaborators from the @Bartek_Lab https://t.co/6PuUoixirt
Check out our latest review, published in BioEssays, on how DNA damage triggers secretory responses that drive aging across tissues and the potential ways to delay systemic decline.
Read it here: https://t.co/poNV69BEcF
New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling @CellReports. Congratulations to first author Antonio Galarreta and to all co-authors. https://t.co/WE2QHsIs0S. #Microscopy#RNAiScreen#Condensates
Are transcription-associated histone marks involved in restoring transcription after DNA damage in human cells?
Read the surprising outcome in our new preprint 👇
https://t.co/aGBipaHqhK
Very proud of this international collaborative team effort defining ERCC1-hepatorenal syndrome as a severe multisystem DNA repair disorder with high mortality and pediatric liver cancer risk. Thanks to all families and collaborators. @LUMC_Leiden https://t.co/k8sk8Dlj5N
📣New opportunity for #Postdoc researcher!📣
If you are interested in #telomeres and #Cancer, and want to study how TERRA supports survival of ALT cancer cells, don’t miss this chance!
Application details at https://t.co/8EMn5oIvx1. Email us ([email protected]) for more info.
Here is the link https://t.co/sPOgaWVDFy for everybody to read our most recent Review on #aging and #cancer published in @NaturePortfolio Aging coauthored with @LTrastus - happy to read your comments.
https://t.co/Kc6EgXY88Y
New paper with @KokicGoran and @SvejstrupLab in Cell Press! We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.
Great teamwork by @dianavandenheu2 , @MartaRodrgzMart, Paula van der Meer!
https://t.co/MofmQmpccW
1/6
🚨 New publication in @MolecularCell ! We reveal STK19 as essential transcription-coupled DNA repair factor, stabilizing the TC-NER complex and enabling efficient RNA Pol II ubiquitylation & TFIIH recruitment.
➡️https://t.co/Rzzah46RMJ
I’m so thrilled to share my first first-author pre-print! 💪🎉🥳
This was an amazing collaborative work from @Tanejalab, @AguileRloop and @lugerlab!
How do #chromatinremodelers, #Rloops and mutations in #cancer correlate? A small 🧵below for you!
https://t.co/IocbZWYMwK
📣New opportunity for #Postdoc researcher!📣
If you are interested in #telomeres and #genomestability, don’t miss this chance!
Application details at https://t.co/Z50GFthXVi. Feel free to DM or email us ([email protected]) for more info.
Vacation code: IMM/CT/71-2024
How are DNA-protein crosslinks like camptothecin-induced TOP1ccs resolved?
Check it out in our freshly baked @NatureComms paper: https://t.co/qekcMCaxbL
@duxin_lab