Barbara Grünwald

PI @UniklinikEssen @unidue_zmb, adjunct @pmcancercentre. Systems Biology & Heterogeneity Lab.
Came for the science, stayed for the phenomenal people. She/her

[Barbara Grünwald @BarbaraGrnwald]

So excited to share this with you all!😃@rmkhokha and I revisit a core assumption in cancer biology: is tumour heterogeneity a reflection of disorganization? Our thoughts on how self-organization shapes tumour tissues, and why that matters for oncology: https://t.co/c3iTg9oIsJ

[Giulia Biffi @BiffiGiulia]

🎉 Very happy to have had the opportunity to contribute to this latest @DiseasePrimers #Review on #PancreaticCancer together with a number of great colleagues! @ednacukierman @EileenMOReilly @SaurLab @BarbaraGrnwald ...

Hope it is a useful read! 😊💜

https://t.co/Q6dZPdHClD

[Anirban Maitra @Aiims1742]

The New York Munich Goettingen crew has landed in Lisbon for @BottonChampPanc #PancreaticCancer research meeting!
@SaurLab @MaxReichertMD @ChiaraFalcomata @BarbaraGrnwald

[Anirban Maitra @Aiims1742]

Terrific preprint by @hartjackson using imaging mass cytometry (IMC) & matched genomics for building multimodality prediction models:
Integrated spatial proteomics of human PDAC uncovers an expanded tumour–immune– stroma spectrum with genomic associations
https://t.co/zb4njVsBId

[Mikala Egeblad @megeblad]

Proud to share @niseto’s (new PI @TheCrick) paper:
As a postdoc (@CSHL/@HopkinsMedicine), he found #NETs in necrotic tumors—I shrugged. But he looked closer: NETs block tumor vessel perfusion, causing necrosis, hypoxia, EMT & #Metastasis.
https://t.co/gsaUTA1dfw
@JHU_BDP @Nature

[Barbara Grünwald @BarbaraGrnwald]

@Aiims1742 @rmkhokha Always so kind, Anirban, thank you!

[Barbara Grünwald @BarbaraGrnwald]

So excited to share this with you all!😃@rmkhokha and I revisit a core assumption in cancer biology: is tumour heterogeneity a reflection of disorganization? Our thoughts on how self-organization shapes tumour tissues, and why that matters for oncology: https://t.co/c3iTg9oIsJ

[Barbara Grünwald @BarbaraGrnwald]

Huge thanks to @naturerevcancer, especially @gabe__brewer and our thoughtful reviewer (whoever you are) for their valuable feedback and help 🙏

[Grainne O'Kane @graokane]

Final COMPASS trial data advanced #PDAC
➡️268 WGS& 253RNA-seq
➡️basal-like& hi GRIm-S ⬇️OS, both unique TME inc CD8 variation,NB primaries vs mets
➡️LTS :HRD, KRAS WT
➡️KRAS major enriches basal, >type II DM
➡️LAPC≠intact SMAD4
➡️47% receive 2nd line tx
https://t.co/wXcQY1kPvR

[Irene Esposito @IEspositoPATH]

First day @EurPancClub 57th meeting in Düsseldorf https://t.co/XJZ40R2wrr 🤯🤯🤯 Joint post-graduate course with @ESP_Pathology: Great start with excellent pathology talk by Volkan Adsay 👏🥇💥💥💥

[Anirban Maitra @Aiims1742]

New cross species study examining #PancreaticCancer precursors in @jclinicalinvest from @NeehaZaidi @wonjinho1 @DrLizJaffee @hopkinskimmel
Spatial Proteomics and Transcriptomics Reveal Early Immune Cell Organization in Pancreatic Intraepithelial Neoplasia
https://t.co/UpJrd2CYYt

[Anirban Maitra @Aiims1742]

Funny how two of the more interesting pieces of data at #ASCO25 have little to do with extraneous medications per se, but rather the body’s circadian rhythm and physiology:
1: Exercise after surgery
2: Checkpoint inhibitors in the morning

[Irene Esposito @IEspositoPATH]

https://t.co/Zrtjqh5QOT

[Emre Kocakavuk, MD, PhD @ekocakavuk]

Evolutionary fingerprints of epithelial-to-mesenchymal transition | ⁦@Nature⁩ https://t.co/oU1aRyHKfq

[Eduard Porta @eportacangen]

It took 3 years, 4 rounds of reviews, 96 VISIUM samples, 10 cancer types, and 1 clinical trial, but it's finally out:

The spatial landscape of Cancer Hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity

Here's what's new 👇

https://t.co/WMCyTWhVOX

[Barbara Grünwald @BarbaraGrnwald]

🚨New paper alert: Intratumoral co-existence of PDAC subtypes -- what's the environmental drivers and underlying mechanisms?

A fantastic collaboration with @ShivKSingh6's team, just out in @NatureComms !👨‍🔬

[Shiv K Singh & Lab @ShivKSingh6]

📢 Excited to share our study in @NatureComms, previously available on bioRxiv by Klein et al.
👉 https://t.co/tqT4g9d39B

[Barbara Grünwald @BarbaraGrnwald]

... @c_mccloskey1 @fpvyas @Kazeera2 Dr. Melanie Börries’ team, at @pmcancercentre @OICR_news @UHN and @Uniklinik_Fr

[Barbara Grünwald @BarbaraGrnwald]

💜 It is extra sweet to see this work having impact because it was 100% driven by collaboration.

A shoutout to phenomenal colleagues who just never hesitate to offer their best, including @rmkhokha @KislingerThomas @LabNotta ...

[Anirban Maitra @Aiims1742]

Another seminal paper - this one from @BarbaraGrnwald & @rmkhokha in @CellCellPress on Spatially confined sub-tumor microenvironments in #PancreaticCancer really helped define the concept of "neighborhoods" in this disease. Published in 2021 and cited close to 300 times.
https://t.co/g692Xbv71e

[Anirban Maitra @Aiims1742]

Which are the highest cited original research publications in #PancreaticCancer over the past five years (from 2020 to 2024 end)?
All metrics obtained from Google Scholar (caveat: GS tends to OVERESTIMATE citations but the trends are consistent overall).
🧵 Below:

[Barbara Grünwald @BarbaraGrnwald]

... please go right ahead and send me your CV plus a brief description of your interests and expectations.

[Barbara Grünwald @BarbaraGrnwald]

📢We are hiring on several levels: research admin (50%), PhD student and post-doc! 🧑‍🔬👩‍🔬🧪🧬🧫

Official job postings to follow but if you already agree that tumor ecosystems and translational systems biology are totally awesome...