Being chakravarthy

சிபிச்சக்ரவர்த்தி | First gen | B cells immunology | Allergy | Antibody discovery | Alpha gal | Infectious diseases | Vaccines | 🇮🇳🇮🇱🇺🇸 | Opinions my own.

[Waggoner Lab @LabWaggoner]

Plasma membrane order maps functional diversity in immune cells @nchembio 🇸🇪 @Sciezgin
https://t.co/d6Xx1ErdNt

[Waggoner Lab @LabWaggoner]

B cell responses to CD40 stimulation ignite anti-tumor immunity by activating CD8+ T cell cytotoxicity @CellReports @hollern_daniel @salkinstitute @khvn15 @Monika_Ramos20
https://t.co/Jv8IIO3Uan

[Waggoner Lab @LabWaggoner]

Targeting tumor-associated macrophages using mRNA lipid nanoparticles for cytotoxic T lymphocyte–mediated cancer immunotherapy @ScienceAdvances
https://t.co/k7UFPRrp8J

[Journal of Allergy and Clinical Immunology @jacionline]

How do innate immune cells interact with adaptive immunity to promote the development of chronic type 2-mediated diseases? A better understanding may be key to the identification of new biomarkers and therapeutic approaches. Review recent advances here. https://t.co/ihYt8xFbhS

[Waggoner Lab @LabWaggoner]

Unphosphorylated tyrosines mediate PD-1 inhibition of T cell signaling condensate formation
https://t.co/DVIlxe0P3D
https://t.co/0A1aZKXylm
@sciencemag @genentech

[Dr. Thomas Ichim @exosome]

Immunological heresy....the T cells in the tumor do not need to be tumor-specific to kill the tumor...

Nature paper

Add some #anktiva by $IBRX , use some dc by #NWBO and you have a great treatment !

https://t.co/jZoJ2IH8zq

[Olivia C. Ghirardelli Smith @oliviacs_]

1/ T cell immunotherapies are thought to require tumor-specific T cells. Very excited to share our work showing how T cells can eliminate tumors without tumor specificity via paracrine signaling. 🧵
https://t.co/p5QnmRtm3f

[Nature Reviews Drug Discovery @NatRevDrugDisc]

This Review in the September issue discusses the evolving landscape of drugs targeting claudins in cancer, including monoclonal antibodies, CAR-T cell therapies, antibody-drug conjugates and bispecific antibodies
https://t.co/8TmtqHUMJB
https://t.co/N44SLrMDyq

[Cell Genomics @CellGenomics]

scXpand: Pan-cancer detection of T cell clonal expansion from single-cell RNA sequencing without paired single-cell TCR sequencing https://t.co/tfQjEYWGGn

[Journal of Clinical Investigation @jclinicalinvest]

Proposing a combination treatment for reducing death from cerebral malaria: https://t.co/BqGOVHvjOz

Alvin H. Schmaier @AlvinSchmaier & team @cwru report on a role for bradykinin in cerebral malaria and find plasma kallkrein inhibitors target host-mediated vascular dysfunction. Combination treatment using kallikrein inhibition and artesunate showed therapeutic benefit in mouse models.
@the_asci
#CerebralMalaria

[Immune Regulation News @Immune_News]

Researchers propose that integrating multiple induction strategies during the Treg cell induction process is crucial for designing Treg cell therapies with superior functionality and broader applications.

Read the full paper here: https://t.co/eJJIUODjdh

Led by first author Yaqi Chen (Zhejiang University) and corresponding authors Yingying Shi (Westlake University) and Jian You (Zhejiang University School of Medicine).

#Lymphocytes #Immunotherapy

[Cell Reports @CellReports]

B cell-guided inflammatory cascade perpetuates ICI-mediated colitis https://t.co/pstBnNqHsd

[Waggoner Lab @LabWaggoner]

Nociceptor activation impedes tertiary lymphoid structure assembly through CGRP. Cigarette smoke engages this neuroimmune axis to promote tumor growth independently of mutagenic effects
@ImmunityCP spotlight
https://t.co/efp4uQL1Kj
on @CellCellPress
https://t.co/zct4FtjJ2G

[Nature Reviews Drug Discovery @NatRevDrugDisc]

The landscape for in vivo CAR T cell therapies
https://t.co/pcCqfaczQI

This article analyses the pipeline of in vivo CAR-T therapies for cancer and autoimmune disorders, highlighting trends in delivery technologies, targets and indications.

[Nature Reviews Drug Discovery @NatRevDrugDisc]

For readers interested in the potential of in vivo CAR-T cell therapies for cancer and autoimmune diseases, here's a comprehensive review by pioneers in the field
https://t.co/AEVGaTClxy
https://t.co/VZojof75jl

[Eric Topol @EricTopol]

In 2025, Keytruda (pembrolizumab) was the number one drug for global sales ~$32 billion, targeting PD-1, for cancer immunotherapy. But we didn't know precisely how it works until today @ScienceMagazine
https://t.co/uIt3jDXzWW
https://t.co/xnxlg6burf

[Nature India @NatureInd]

An experimental antivenom cocktail tested in mice neutralizes toxins from the king cobra and some of its cousins in India

https://t.co/N6bsoEzKsl

[Niko McCarty. @NikoMcCarty]

Bunsen burners don’t reduce contamination. It was all an illusion. My biology teacher was wrong.

This isn’t surprising, though. So much of biology, and the way we do experiments, claims to be “scientific” but is actually swaddled in mysticism.

Just walk into a laboratory and watch biologists for a day; they will do all sorts of weird rituals that — if you ask them to explain — will elicit no answer other than, “Well, that’s the way I was taught to do it.” Why are washes always five minutes long, for example? Why are they always done in groups of three? Did anybody actually ever measure this stuff?

The Bunsen burner wasn’t even invented for its modern use. Robert Bunsen, a German chemist, invented it in the 1850s to heat up his chemical reactions. Microbiologists later used it to flame and sterilize instruments, which makes sense. And then there was all this debate and controversy about Pasteur’s swan-neck flasks, and this idea that microbes were floating in the air and contaminating things, and so microbiologists decided to take the Bunsen burners they had used to sterilize instruments and just …. put the open flames on their benches to sterilize the air. But this was pure mysticism. Nobody ever actually studied whether or not this worked.

Someone ought to open up a lab and raise money to run “mysticism experiments.” Like, how bad is it (really) if we don’t wash things for five minutes in three cycles? How bad would it be if we didn’t incubate with antibodies at 4 degrees Celsius overnight? Why do cells eventually saturate in LB media? (Some people argue it’s because they run out of carbon, but others claim that's totally a lie and it's actually the magnesium.)

Much of experiment is tacit illusion.

[Waggoner Lab @LabWaggoner]

Review @sigtrans_sttt
B cells in cancer: functions, mechanisms and therapeutic advances
https://t.co/VNoaEUeN4g

[David M. Sabatini @DMSabatini]

Very nice paper
https://t.co/iJBoX3hUwa