Benjamin Klein, MD

Dermatologist and currently postdoctoral fellow @UMich @kahlenberglab 🏳️‍🌈

[Benjamin Klein, MD @ben_derm]

I’m thrilled to share our preprint about the role of ZBP1 and Z-DNA in autoimmune photosensitivity. So grateful to my amazing mentor @Kahlenberglab and our collaborators in @DrBadBug ‘s lab. And great thanks to @WestLabMito for inspiration!

https://t.co/t5wMkqZqMI

[NatRevRheumatol @NatRevRheumatol]

New content online: Cutaneous lupus erythematosus — from pathogenesis to targeted therapy https://t.co/2XzDmIrUdk

[U-M Department of Internal Medicine @UMIntMed]

Dr. Benjamin Klein @ben_derm & the @Kahlenberglab identify key regulators & potential treatment targets in photosensitivity, representing an important step in understanding how to better protect the skin from harmful lesions caused by UV irradiation. https://t.co/QbZZA2Wwbr

[Science Immunology @SciImmunology]

New research suggests that mitochondrial Z-DNA and Z-DNA binding protein drive UV-induced photosensitivity in #lupus and #dermatomyositis. @Kahlenberglab @ben_derm https://t.co/HvbaUQTP6Y

[Science Immunology @SciImmunology]

Science #Immunology's March issue is out!

This month's cover highlights the mechanisms underlying autoimmune #photosensitivity. UV-damaged mitochondria release #ZDNA into the cytoplasm and trigger inflammatory signaling. Read about this research and more: https://t.co/1RxSTu94vd

[Benjamin Klein, MD @ben_derm]

@Lo_Zanzi @Kahlenberglab @SciImmunology Thanks for highlighting our work 😊

[Ivan Zanoni @Lo_Zanzi]

#InterferonFriendOrFoe?! @ben_derm @Kahlenberglab &co show @SciImmunology that UV drives Z-DNA to induce type I & III IFNs in keratinocytes. IFN-I upreg ZBP1 that binds Z-DNA activating cGAS-STING to boost IFNs, photosensitivity & inflammation in #Lupus! https://t.co/dKzTg6BLLj

[Waggoner Lab @LabWaggoner]

ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation
https://t.co/lNElFYDmM0
@SciImmunology @ben_derm @Kahlenberglab

[Allergy EAACI @AllergyEaaci]

Dichotomous STAT5 and STAT6 Activation in T Cells Reflects Cytokine Shifts Between Blood and Skin in Atopic Dermatitis. First author: Andreas Boldt; corresponding author: Benjamin Klein

Read the article here: https://t.co/FAihFiy53w

The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) signaling pathway is central to the pathogenesis of atopic dermatitis. In this study, Bold et al., analyze the STAT activation in T cells in the peripheral blood of atopic dermatitis patients and compare it to that of the skin.

Read more articles published in #Allergy on #atopicdermatitis here: https://t.co/9Ex66XCT04
#Allergy_journal

[Signal Transduction and Targeted Therapy (STTT) @sigtrans_sttt]

#STTT highlight Nordmann, T. M. et al. Spatial proteomics identifies JAKi as treatment for a lethal skin disease: Klein, B., Kahlenberg, J.M. & Gudjonsson, J.E. Proteins lead the way: JAK inhibitors as a new treatment option in toxic epidermal necrolysis. https://t.co/3wTvApkHTf

[Michelle Kahlenberg @Kahlenberglab]

Thanks @MichelGillet for coming to UM for the SBDRC symposium! Excellent talk!

[Michelle Kahlenberg @Kahlenberglab]

I present new work that we are super proud of. Explains why type I IFNs promote enhanced photosensitivity. Outstanding work by @ben_derm and team!!!! Hopefully reviews will go smoothly! 🤞🏻🤞🏻🤞🏻https://t.co/P02Idmoz8L

[A. Phillip West @WestLabMito]

Cool preprint showing that ZBP1 works in concert with cGAS to sense Z-form mtDNA and drive IFN-I in autoimmune photosensitivity. Great to see overlap with our recent work. Congrats to the research team! https://t.co/XSOKBEWlR2

[Antony Psarras @AntonyPsarras]

Our previous analysis of pDCs published in @NatureComms showed that pDCs do not contribute to type I #interferon production in #SLE but they are immunologically exhausted. New work @theJIDJournal from V Werth’s group confirmed our data in cutaneous #lupus!
https://t.co/MYFrusF3vA

[Laurent ARNAUD @Lupusreference]

🚨 Exclusive RED #ALERT on CAR-T cells (click below for more) ⬇️ The @US_FDA has received reports of T-cell malignancies 🚨 including CAR-positive #lymphoma, in patients who received treatment with BCMA- or CD19-directed #CART cell immunotherapies
https://t.co/Kd539rhcKu

[Benjamin Klein, MD @ben_derm]

Honored that I had a talk at #ACR2023 about my project investigating #autoimmune #photosensitivity in #lupus and #dermatomyositis
And thanks to my amazing mentor
@Kahlenberglab

[Antony Psarras @AntonyPsarras]

Great #immunology presented by @ben_derm from @Kahlenberglab at #ACR23 on the role of Z-DNA in keratinocytes and the perpetuation of type I #interferon inflammation in cutaneous #inflammation of #lupus patients.

#sle #rheumatology #dermatology #autoimmunity

[Mount Sinai Health System @MountSinaiNYC]

“The reason I went to medical school [was] to help other people with skin diseases.”
—Dr. @EmmaGuttman

Learn more: https://t.co/ZkBZ52lrep

For an appointment call 212-241-9728 or email [email protected]

#EczemaAwarenessMonth

[John Lukens @LukensJohnR]

cGAS–STING drives ageing-related inflammation and neurodegeneration. Great paper @Nature
https://t.co/prpAkNGfTu

[Journal of Experimental Medicine @JExpMed]

New review from Maelfait @InflamResCen & Rehwinkel @RDMOxford: ZBP1 is an innate immune sensor for double-stranded nucleic acids adopting the Z conformation. Z-RNA/DNA is generated during viral infections and in autoinflammation and cancer. https://t.co/1NKnXQT8U4