Bharat Poudel

Working at interface of Physics and Drug Design.#HalaMadrid

[Bharat Poudel @bharat6774]

Excited to share our latest work on Mechanical activation on AT1 receptor. We have investigated the membrane sensitivity, role of membrane tension on AT1 receptor activation through enhanced sampling and long timescale simulations. #compchem# #GPCR# #MembraneBiology#

[Juan Vanegas @VanegasLab]

A great accomplishment for our lab! Excellent work by Dr. Bharat Poudel: https://t.co/QITfu2M2IX @bharat6774 @uvmcems @uvmvacc @OSUScience @OregonStateBB

[Bharat Poudel @bharat6774]

I dived into mechano-sensitive channels/receptors in 2019, Nobel drops for them in 2021. I geek out over J. Jumper’s algorithm structure prediction since 2020, and he snags a Nobel in 2024. Now I’m have just started MOFs project and guess what? MOF folks just nabbed a Nobel 😀😀

[Wokil Bam @WokilBam21]

I am looking for a graduate student to join my lab to work on the Underwater Vision Profiler (UVP) data to investigate the particle dynamics, and their pivotal role in trace metal cycling in the Southern Pacific and Southern Ocean !!

[Bharat Poudel @bharat6774]

Our work on GPCR responses to the mechanical forces had been highlighted by the Pittsburgh Supercomputer 👇.

[PSC @psc_live]

GPCR proteins are central to cells’ responses to the body’s messages, and are central to over 1/3 of all approved drugs. A team from @OregonState used Anton 2 to investigate the proteins' surprising behaviors.

Read more ➡️ https://t.co/1pt2Q18zed

[Bharat Poudel @bharat6774]

Excited to share our recent publication on thermal degradation of fentanyl and its analogs. These synthetically modified analogs have a huge potential for abuse and been widely spread in the market in the last decade.
#compchem

https://t.co/8uyGdGXjzB

[Bharat Poudel @bharat6774]

The same journal pays nothing for reviewer but charge thousands of $$ for publication. Now they are advising on how to avoid a free labor. Hypocrisy at its finest

[nature @Nature]

It can be hard to say no to service requests in academia.

We sought advice on how to ensure researchers don’t get stuck doing unpaid labour
https://t.co/SlEz9FKkTL

[Bharat Poudel @bharat6774]

@caco3cz That’s interesting.

[Adrian Roitberg 🏳️‍⚧️ @adrian_roitberg]

@GonzaParra_ And the PDB Dataset, a free, public, open repository.

[The Nobel Prize @NobelPrize]

“I got the phone call and my wife promptly started screaming.”

The 2024 #NobelPrize in Chemistry gave David Baker’s household an early wake up call.

We talk about the potential of building new proteins and the inspirational effect his fellow laureates have had on his field.

[Bharat Poudel @bharat6774]

@Nep_Achyut @DhakalGyanendra Chemistry and physics both taken away by ML/AI. May be medicine too in future.

[Bharat Poudel @bharat6774]

Glad, It’s official that ML is now a part of physics.

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

[The Journal of Physical Chemistry @JPhysChem]

Extensive MD simulations (over 175 μs) show that the AT1 receptor, an important GPCR in cardiovascular regulation, is modulated by its surrounding membrane through changes in thickness & stretch @OSUScience @OregonStateBB @VanegasLab @bharat6774 @psc_live
https://t.co/8BlIhz0eLc

[Juan Vanegas @VanegasLab]

Our latest paper is out: @VanegasLab used MD simulations to understand how the function of the AT1 receptor, an important GPCR in cardiovascular regulation, is modulated by membrane thickness and tension. @OSUScience @OregonStateBB @bharat6774 @psc_live https://t.co/oAk7jcwyEi

[Bharat Poudel @bharat6774]

Structural Rearrangement of the AT1 Receptor Modulated by Membrane Thickness and Tension | The Journal of Physical Chemistry B https://t.co/IXWwq8YQln

[Bharat Poudel @bharat6774]

@WokilBam21 Congratulations brother! Well deserved one! Not the roots though but my wings are connected to that school 😀. Can you please hire me as your firs Grad Student?

[Bharat Poudel @bharat6774]

🎯

[Sophien Kamoun @KamounLab]

@moorejh What would happen if the Editor does this and the journal is Nature? Would the author say anything?

[Bharat Poudel @bharat6774]

How can one publish 2.18 papers per day? Does he/she know the title of the paper let alone the science in it? Is it a meaningful contribution to the science? 🤦

[Publishing with Integrity @fake_journals]

.
22 people have published more than 200 papers in 2024 (so far, we still have another six months to go)

We have been doing some research on another project and saw something that we found interesting. We'd be interested to know what you think.

In 2024, 22 authors (according to @Scopus) have published over 200 papers. The table below shows the details (we decided not to show author names at this time).

The author who has published the most papers has authored 261 papers (as at 15 Jun 2024) meaning that he/she has published 1.56 papers every day this year (and counting).

If we exclude weekends (everybody has to rest, right?), then they have published 2.18 papers every day.

Serious question: Is it possible for anybody to contribute in a meaningful way (at least to warrant being at author) when they are publishing a paper every day?

[Bharat Poudel @bharat6774]

Kardashian index 😀😀

[Olexandr Isayev 🇺🇦🇺🇸 @olexandr]

🤯 We should definitely upgrade this and rank US universities by Kardashian index 😉 ( ~ number of twitter followers divided by number of citations). All of these schools are probably overhyped

[Bharat Poudel @bharat6774]

This is indeed a good news but what is puzzling here is the unrealistic hype in the mainstream media, which might creates bubbles. We will still heavily rely on human judgement, clinical trials inclusng other non-AI things.
https://t.co/3QQw3BqRaB.

[Bharat Poudel @bharat6774]

The conclusion was solely based on the presentation presented on the conference. Take it with grain of salt.

[Bharat Poudel @bharat6774]

8-hour time-restricted eating linked to a 91% higher risk of cardiovascular death https://t.co/3R9a0NKdcN

[Bharat Poudel @bharat6774]

This is just a preliminary research presented at the American Heart Association’s Epidemiology and Prevention│Lifestyle and Cardiometabolic Scientific Sessions 2024, March 18- 21, in Chicago. This one is not published yet on a peer reviewed journal.