Bill Ling

Chemical Engineering PhD @Caltech

[Mikhail Shapiro (same on bsky) @mikhailshapiro]

Congrats to Dr. @ZhiyangJin on a phenomenal PhD thesis defense on acoustic biosensors! 🎉

Zhiyang's work broke fundamentally new ground in connecting ultrasound to dynamic cellular signals such as proteases and calcium.

[Mikhail Shapiro (same on bsky) @mikhailshapiro]

Can you evolve an acoustic protein? Yes, but first you have to invent a system for high throughput acoustic screening!

Congrats to @robertchurt, @ZhiyangJin and colleagues on this advance in biomolecular ultrasound. #gasvesicles

https://t.co/rpT5m9eKvk

[George Lu @georgeluPhD]

#gasvesicles are tiny gas-filled organelles that serve as flotation devices for microbes, and microbes pack them in a beautiful honeycomb pattern to maximize space-saving. What is the protein that regulates this process, and what is the role of #condensate? See our paper @NatureMicrobiol, and cheers to all the collaborators @lingchongyou, Ashutosh Chilkoti, Yifan Dai, and @alexholehouse.

[Bill Ling @bill_ling]

@NikoMcCarty I thought @mikhailshapiro discovered them 😃😃

[Jacob Robinson @JTRobinsonLab]

Can’t wait to take the next step with @motifneuro!

This funding will allow us to launch the first clinical trial with magnetoelectric-powered implants - a new architecture for neuromodulation.

Credit to team at Motif and the supportive environment at Rice and the Launchpad!

[Mikhail Shapiro (same on bsky) @mikhailshapiro]

Where do #gasvesicles live in a mammalian cell?
The cytoplasm, as we can see w/bioorthogonal labeling w/FlAsH!

Congrats to Erik Schrunk, co-sr auth @di_wu_ & co on a fractional labeling method that may also be useful for other protein nanostructures.

https://t.co/r9tJH5XQBN

[Whitney Griggs @WhitneySGriggs]

A paper from my PhD is officially out today at @NatureNeuro where @SumnerLN and I demonstrate a closed-loop ultrasound-based brain-machine interface (BMI)!!

Link to paper - https://t.co/IlpcDYkjHr

A #tweetprint. 🧵1/12

[Sumner L Norman @SumnerLN]

Forest Neurotech is hiring!

Three roles on the engineering team (Palo Alto, CA)

- Principal Mechanical Engineer
- Principal Electronics Systems Engineer
- Principal Engineering Program Manager

@ all my Neurotech friends -- please share 😊

https://t.co/tjTBLdr9fG

[Mikhail Shapiro (same on bsky) @mikhailshapiro]

Can we image intracellular calcium with ultrasound?

Yes, w/ultrasonic reporters of calcium - URoCs!

Congrats to @ZhiyangJin and co-authors on creating the first genetically encoded acoustic biosensors of this universal cell signal based on #gasvesicles.

https://t.co/cXqHM3awH4

[Nature Materials @NatureMaterials]

Magneto-gas vesicles, protein nanostructures with enhanced ultrasound signal and sensitivity, enable the non-invasive, long-term and quantitative monitoring of the mechanics of three-dimensional tissues and animals @yonsei_u @mikhailshapiro @IBS_media https://t.co/u3DKCWVLS1

[(Amir)Hossein Salahshoor @HosseinSalahsho]

Excited to start my new journey as an Assistant Professor @DukeEngineering Most sincere gratitude goes to my supervisors and mentors: @JulianRimoli , Rafael de la Llave, Michael Ortiz, @mikhailshapiro, Ravi... and thanks to many incredible colleagues at Georgia Tech and Caltech

[Maxwell Robb @Maxwell_Robb]

Delighted to share the latest paper from @TheRobbGroup in collaboration with @mikhailshapiro’s group online now in @PNASNews. Mechanophore activation using #biocompatible focused ultrasound! Huge congrats to @Molly__McFadden and @yuxing_yao and coworkers! https://t.co/W18TZg5zKt

[Mikhail Shapiro (same on bsky) @mikhailshapiro]

Can a living material made of bacteria sense when it's too cold and make a chromophore to heat itself up with sunlight? 🌞 Yes, using thermal bioswitch circuits!

Congrats @LealiaXiong, Michael Garrett and collaborator Julia Kornfield on this paper.

https://t.co/t401vEemGD

[Daniel Heller @Dan_A_Heller]

New technologies to study the hallmarks of cancer! Congrats @mijinee_hi and @magdalinipan and colleagues at @MSKCancerCenter on putting together this terrific review of micro/nanotechnology approaches to investigate tumor ecosystems, in Nature Cancer. https://t.co/sQfAi5RCjK

[The Chan Lab @TheChanLab]

🚨🚨🚨New paper🚨🚨🚨

@Matt___Nguyen et al. found that NPs exit solid tumours through the lymphatics in a size dependent mechanism, and proposed a new mechanism of NP delivery to tumours called the Active Transport and Retention (ATR) principle 🥵🌶️

https://t.co/VUUW69JsHT

[Bill Ling @bill_ling]

Excited to share our study on the blood interactions of GVs! Special thanks to @ko_polymer for developing the surface functionalization chemistry and @ben_stordy @TheChanLab for their work on the protein corona!

[Mikhail Shapiro (same on bsky) @mikhailshapiro]

What's the bloody mechanism behind the ultrasound contrast dynamics of #gasvesicles in circulation?
Congrats to @bill_ling and collaborators at @Caltech and @TheChanLab on finding out!
https://t.co/hHqWMEP8R2

[George Lu @georgeluPhD]

#gasvesicle requires a coordinated effort of 7-20+ proteins to assemble. As a first step to unravel this intriguing process, we constructed a systematic protein interaction map and hypothesized proteins in each assembly stage. Big cheers @ManuelIburg & co.
https://t.co/dQ31rf9QfD

[Bill Ling @bill_ling]

Also check out this study from @QionghuaS @ZLi44to91 and @georgeluPhD showing another approach to make tiny GVs for imaging lymphatic tissue!

[George Lu @georgeluPhD]

We have shrunk #gasvesicleto the size of a virus, and to our knowledge, these are the smallest stable, free-floating bubbles made to date. Check out the 50-nm GVs and our demo of their penetration to lymphatic tissues. Congrats to @QionghuaS @ZLi44to91.
https://t.co/wFicnmztZm

[Bill Ling @bill_ling]

Excited to share our work on tiny #gasvesicles for ultrasound imaging and therapy!

[Mikhail Shapiro (same on bsky) @mikhailshapiro]

Honey, we shrunk the #gasvesicles!
Congrats to @bill_ling et al on a new class of Truly Tiny ultrasound agents with dimensions of ~60nm. They're small but mighty - producing ultrasound contrast, seeding therapeutic cavitation, and getting into tumors. https://t.co/kaTV7EtRrA

[George Lu @georgeluPhD]

Microbes pack #gasvesicle into tight bundles to save their cytosolic space, and yet the molecular mechanism underlying this process remains unknown. Now we may know why. Grateful to our collaborators Chilkoti Lab and @lingchongyou. More detail -> (1/n)
https://t.co/RaoxlllC5k