Louis Maddox

Bio,chem,code∈combiℕatorics. ML & systems biology. Sci paper feed @naivelocus, tech alt. @permutans, & maths papers @appendens.

[Louis Maddox @biochemistries]

#FirstPaper ! 🍾😀💫 Molec. principles of gene fusion-rewired PPI nets in cancer https://t.co/LJQcpbiflM @MRC_LMB @MolecularCell HT @naivelocus

[nature @Nature]

Tasmanian devils’ contagious facial cancers sequenced for first time https://t.co/ElBB7zpzmu

[Louis Maddox @biochemistries]

Potential differences in ion density can occur not just across PL membranes but on microdroplets of water and air, including it turns out biological condensates, driving redox https://t.co/bi4dvXF6y4

[Phys.org @physorg_com]

Newly discovered electrical activity within cells could change the way researchers think about #biologicalchemistry https://t.co/xKcVtvHRVi https://t.co/McmJmtUMIY

[Louis Maddox @biochemistries]

!

[Phys.org @physorg_com]

Researchers decipher the structure of protein methyltransferase from the mpox virus @IOCBPrague @NatureComms https://t.co/hx2ujEbhNU https://t.co/RReYDbp1Nc

[NimwegenLab @NimwegenLab]

Hey, weren't you a co-author on that?
https://t.co/sDBpU9UPnZ
Yes, I was, but the Nature editors neutered the letter to the point that I felt I could no longer in good conscience put my name on it. The most egregious (and final straw for me) was the insistence to change 1/n

[Aaron @aaron_mckenna]

Pretty awesome survey of what ChatGPT can do: https://t.co/Ay54iKkGPq. We've changed our graduate bioinformatics class to allow/encourage LLMs, it's nice to be able to focus on the bigger picture in homework questions (+ edge cases).

[Louis Maddox @biochemistries]

Comparison of 1,800 de novo vs. 1,800 randomly computer generated proteins found they are moderately more soluble, despite similar structural potential/protease resistance after controlling for AA freq/length https://t.co/YyzFqPlWTI
📄 Heames et al. (2023) https://t.co/FBMt78zE10

[Louis Maddox @biochemistries]

✍️ The seahorse has two tendons that allows it to lift its head and suck in prey at high speed https://t.co/J5RjVFZdvF
📄 A power amplification dyad in seahorses (2023) https://t.co/PsWixkvB0y

[Phys.org @physorg_com]

Naming system for #transferRNA fragments to increase research productivity, standardization @naturemethods https://t.co/QZaYuZP4H8 https://t.co/b6x88vYJpt

[Louis Maddox @biochemistries]

“[Smart Immune]’s experimental cancer trial, hop[es] its novel technology will one day allow HIV patients to rebuild their immune system” — Gates Fdn. usually funds ID but is funding early stage trial in leukaemia patients after chemotherapy, could also improve CAR-T

[FT for Schools @ft4s]

Gates Foundation makes unusual investment in experimental cancer trial https://t.co/bnMp489Dgz

[Science Media Centre UK @SMC_London]

expert reaction to reports that £1.6 Billion of R&D funding has been returned to the Treasury
https://t.co/5VNsBSxIut

[Andrew Dunn @AndrewE_Dunn]

NEW: CRISPR pioneer Feng Zhang is building a secretive new startup to solve gene-editing's biggest problem — getting into more parts of the body

Meet Aera Therapeutics, which has raised $200 million to advance Zhang's work: https://t.co/J4jPmPOOvM

[Paul Mainwood @PaulMainwood]

Booking for boosters 50-64s officially opens tomorrow.
If you’re in that age-range, it might just be worth ignoring the front page text and trying the link now. https://t.co/yihROHQUss

[David Dohan @dmdohan]

ProtNLM (Protein Natural Language Model) annotates previously "uncharacterised proteins" in @uniprot in English

Instead of a restricted tag set, it predicts function as language:
[amino acids] -> "CRISPR-associated endonuclease Cas9"

Collaboration between @GoogleAI and @emblebi

[Helen Branswell 🇨🇦 @HelenBranswell]

.@CDCgov releases very preliminary analysis that suggests the #monkeypox vaccine is offering protection after a single dose. But outside experts urge the finding should be interpreted with a lot of caution. https://t.co/xxh8K0y6uu

[Eric Topol @EricTopol]

"We discovered a simple peptide that inhibits
infection by all major variants of #SARSCoV2 with nanomolar efficacies."
https://t.co/SYaja6vO6m
@PNASNews @emkailu @StanfordMed @HHMINEWS

[Eamon C. Corbett @eamon_corbett]

Why do birds have different eye colors? The short answer is we don't know. The long answer is in our new review article, up now as a preprint! We look at the pigments, genes, and evolutionary forces that give birds eyes their colors. https://t.co/XrvuUl3lll

[Mateo Prochazka @teozka]

It's sobering that, globally, we are not able to produce enough supply of smallpox vaccine at pace to meet the demand for monkeypox control. Many countries with hundreds (or thousands!) of cases have not even started vaccinating yet, let alone launched a vaccination strategy.

[Helen Branswell 🇨🇦 @HelenBranswell]

1. There's a new #monkeypox technical brief out from @UKHSA. Always an interesting read.
A 🧵
HSA's modeling suggests the outbreak isn't expanding, though they acknowledge cases are certainly being missed and that makes it hard to accurately gauge things.

[Sebastian Raschka @rasbt]

Want to tinker with the 200M+ protein structures from AlphaFold in your favorite DataFrame format (pandas!)⁉️

Thanks to a kind contribution by @arian_jamasb, this is now possible in the latest BioPandas dev version as of this morning!

https://t.co/CO6DnCcEb2