Michael Sheets

Bioengineering grad student at BU, BioBuilder educator, @OlinCollege alum. Synthetic biology, human-centered design, & fermented foods. He/him.

[Michael Sheets @biotaxis]

This was an exciting project, and I am so glad we get to share it now!

[Mary Dunlop @DunlopLab]

Antibiotic resistance genes have been a core tool in synthetic biology since the start. In our new preprint by @biotaxis, we develop tools that will enable control over bacterial survival in space and time using light. 🦠💡
https://t.co/VKe2XowiZ5

[Josh Leonard @TheLeonardLab]

An excellent contribution to the literature on SynBio education - congrats to the team @EngBioRC !

Introduction to Engineering Biology: A Conceptual Framework for Teaching Synthetic Biology | ACS Synthetic Biology https://t.co/eBRNGmxgoz

[B is @[email protected] @[email protected] @thuronyi]

Minipreps! They're a fact of life. But if they don't bring you joy, you might want to try new tactics or treat yourself to some fun new toys!

Our lab has done 2,625 minipreps so far. Let me share a few tidbits about our approach and our favorite pieces of equipment. 🧵 (1/n)

[Systems Sally @SystemsSally]

On Thursday we had the pleasure of hosting the Tyngsboro High School's BioBuilderClub Team at our Learning Lab! While here, they performed a bacterial transformation with the DNA plasmid they designed. Great work from these amazing students! #tpsprepares #biobuilder

[Mary Dunlop @DunlopLab]

Our latest paper is out! Light-inducible expression of antibiotic resistance genes. Led by @biotaxis, with help from @NathanTague2. Constructs are on @Addgene if you want to try them out.

[Michael Sheets @biotaxis]

Excited to share my latest work! We use light to turn on antibiotic resistance, and can use this to boost fatty acid bioproduction.

[Ross Cloney @rosscloney]

And to wrap up today's paperfest, @biotaxis and co in the @DunlopLab at @BostonU_BME present an optogenetic toolkit for light induced antibiotic resistance

https://t.co/eyt8Wue6np

[Chappell Lab @ChappellLab]

Delighted to share our latest paper on the RENDR platform — an engineered ribozyme that can convert RNA signals into orthogonal protein outputs. Published in @NatureComms and led by @laurgamb, @AOStaubus, @Kimwai_Mo, and @andrea_faint. Supported by @NSF

https://t.co/2h7vOd2Cuw

[Systems Sally @SystemsSally]

We are now accepting applications for the 2023 Apprentice Challenge Class! BioBuilder's 8 Week program for Boston area high schoolers that prepares students for summer internships at area academic labs and life science companies.

https://t.co/c2r5vdWzjC

[Kathryn Brink @kathryn_brink]

Interested in bacterial peptide sensing? Check out my latest paper! Thanks to all of my amazing co-authors in
@LabTabor lab + beyond: @synthetic_queer Andrew Mu @KGroszman @KyVanHoang @kevin_lorch @bhpogostin @DrGunn43 @jeffrey_j_tabor https://t.co/gX20h1810H

[EBRC @EngBioRC]

Join the EBRC SPA December 6 for Data and Engineering: Operating at the Technical Interface. Panelists will discuss transitioning to industry, their current role, and valuable data-specific skills. Learn more and register here: https://t.co/ot6LGRP4C0

[Michael Sheets @biotaxis]

@CarlDenard That sounds like a great course! @meeeeechigan @EngBioRC and I put together an Into SynBio slide deck recently: https://t.co/OaiFB3fF0T

[Joff Silberg @JoffSilberg]

Super excited that our paper with @ajofranklinlab, i.e., CAF, is out (https://t.co/QOFzt1IFG6) with @meeeeechigan, @su2lin_SEU, Xu Zhang, and George Bennett. Congrats to all!!!

[Mary Dunlop @DunlopLab]

Very excited to share our new preprint where we use a deep learning-based feedback algorithm to control gene expression in real time in thousands of single E. coli cells in parallel. This work was led by @jblugagne and @cblassick. 1/

[Michael Sheets @biotaxis]

I learned so much through making these slides, and I hope they'll help you learn (and teach) too! Very excited to share a new course module that covers the theory, core tools, and impacts of engineering/synthetic biology: https://t.co/zYDzD2lkqB

[EBRC @EngBioRC]

Looking to teach #engineeringbiology in your course? EBRC is excited to announce a new resource! Our modular slide deck on the impacts and principles of Engineering Biology, by Michael Sheets @biotaxis and Josh Atkinson @meeeeechigan: https://t.co/bYhy7Pbt57

[Möglich Lab @MoeglichLab]

Here's our new article -- potentially, everything you ever wanted to know about light-regulated gene expression in bacteria (& much more).
https://t.co/7A4bN89N7G
Welcome opportunity to team up once again with @RobertOhlendorf (this guy knows stuff!). Enjoy

[Josie Kishi @jykishi]

What if you could image 🔬cells and then choose which ones to sequence 🧬?

What if you could go back and image 🔬cells that you previously sequenced 🧬?

Now you can 🔬 then 🧬 then 🔬 cells again with Light-Seq!

https://t.co/ZuDIOfnqyj

Let’s dig in 🧵.

[Ayari Fuentes-Hernández @irayari]

Genome sequencing of the evolved populations revealed why resistance accelerated in MS but not in SS: mildly-selected resistance mutations were stably maintained without selection, contrarily to strongly-selected mutants that were unstable in drug-free environments.

4/5

[GEN Biotechnology @GENBiotechJrnl]

REVIEW: Deep Learning Concepts and Applications for Synthetic Biology

@DunlopLab and colleagues present an overview of #SynBio relevant classes of data and #DeepLearning architectures and discuss the challenges and future opportunities in this space.

https://t.co/Bfg2eBxxfu

[Mary Dunlop @DunlopLab]

I am pleased to release the @EngBioRC “Synthetic Biology and Machine Learning” education module. In it I talk with synbio/ML researchers about projects in their groups and ideas for how to learn more about this space.
https://t.co/mN3jFpBxpE

[ACLU @ACLU]

BREAKING: The Supreme Court just reversed nearly 50 years of precedent and overturned Roe v. Wade, ending the federal constitutional right to abortion.

We won't deny what a horrible moment this is.

Half of the states are expected to ban abortion.