Bjorn Criel

Fulltime Bio- parttime -tech/-informatics

[De Tijd @tijd]

Vlaamse start-up werkt aan nieuwe generatie antibiotica: ‘Als dit lukt, kunnen we honderdduizenden levens per jaar redden’ https://t.co/FMhMq1D2tp

[Yves Briers @BriersYves]

I am thrilled to announce the launch of our new spinoff, https://t.co/ZPsNXbWWmk! Obulytix is developing a revolutionary solution for antibiotic resistance based on #phage #lysins @ugent @KU_Leuven @bjorncriel Dennis Grimon Maria Fonseca
https://t.co/wfaa6cHJoZ

[Bjorn Criel @bjorncriel]

With an amazing team of co-founders (@Yvesbriers , Maria Fonseca, Dennis Grimon), founding universities (@ugent , @KU_Leuven) and investment funds (@Boehringer Ingelheim Venture Fund, Qbic Fund, Gemma Frisius), we hope to turn @obulytix into a successful biotech spin-off story

[Bjorn Criel @bjorncriel]

The word is finally out 📣
We started a new spin-off company: @obulytix . We envision to revive the antibiotics market with the development of tailored enzyme-based antibiotics using our top-notch screening pipeline. https://t.co/NWPw4pLwAN

[PhaLP @PhaLP_db]

PhaLP v2023_01 is out with 88 new (19452 total) Phage Lytic Proteins .

[konsti @konstinx]

So what happens when you replace BLAST/MMseqs2 with embedding/language model based search?

The latest generation of protein language models (ProtT5/ESM) is really good at remote homology, but there are also a bunch of catches

[ScienceInsider @ScienceInsider]

BREAKING: White House issues new policy that will require, by 2026, all federally-funded research results to be freely available to public without delay, ending longstanding ability of journals to paywall results for up to 1 year. Coverage coming on @ScienceInsider.

[Christian Dallago @sacdallago]

Since the # of "[α-ω](fold){0,1}[A-z]*" tools are getting out of hand, I tried to curate a lil list of the ones I'm aware of: https://t.co/q7P8y93lB7

Peeps w/ overview @sokrypton @thesteinegger @KevinKaichuang feel free to contribute if I missed stuff?

[PLOS Biology @PLOSBiology]

Bacteriophages produce endolysins to degrade host cell walls & release new particles. @smoineau &co use #CRISPR to shed light on #bacteriophage endolysin diversity, phage-bacteria interactions & #endolysin adaptation to a new bacterial host #PLOSBiology https://t.co/MxHJGxTiIE

[Google DeepMind @GoogleDeepMind]

Today in partnership with @emblebi, we’re releasing predicted structures for nearly all catalogued proteins known to science, which will expand the #AlphaFold database by over 200x - from nearly 1 million to 200+ million structures: https://t.co/GjVES2pBFY 1/

[Belgian Society for Viruses of Microbes @BSVoM_official]

Group photo of the BSVoM members present at the @VoM_2022 conference! 😃 Great last day of the conference here in Guimaraēs!

[Bjorn Criel @bjorncriel]

It was a great experience to introduce the PhaLP database to the phage lysin community at @VoM_2022. Thanks to the organisers of this fantastic conference for the opportunity!

[Yves Briers @BriersYves]

Full house for the https://t.co/Yyjlwf1ENe workshop by @bjorncriel on the database for phage lysin research @VoM_2022 Did you miss it? Watch https://t.co/yi2bD8Guhp

[Yves Briers @BriersYves]

Full house for the https://t.co/Yyjlwf1ENe workshop by @bjorncriel on the database for phage lysin research @VoM_2022 Did you miss it? Watch https://t.co/yi2bD8Guhp

[Aël Hardy @ael_hardy]

Frank Oechslin addresses the biological relevance of the diversity of phage endolysins.
Using CRISPR, exchanged endolyins between phages.
Across different phages, endolysins coming from different phages lead to fitness costs manifesting by smaller plaques. #vom2022

[Belgian Society for Viruses of Microbes @BSVoM_official]

Some of the BSVOM members shining on our first day at @VoM_2022 yesterday! Ready fo day 2! Come say hi :)

[Irina Spacova @Irina_Spacova]

@bjorncriel from @ugent discussed machine learning-guided #engineering of modular #enzybiotics to target Enterococcus faecalis infections of the urinary tract. They created PhaLP, a database of phage lytic proteins, that helps facilitate development of new modular enzybiotics.

[Machine Learning for Protein Engineering Seminar @ml4proteins]

Video of Bruce's talk: Machine Learning-Assisted Protein Engineering with ftMLDE and evSeq

https://t.co/qSkJ7aNyXf

[Kevin K. Yang 楊凱筌 @KevinKaichuang]

I've been working with awesome people (@Jody_Mou @brianltrippe @apsoleimany @alexijielu @LucyColwell37) to put this together. I'm really excited for the first 4 speakers we have lined up and look forward to hearing about and discussing cool research.

https://t.co/MOdqxQb6x2

[Dimi Boeckaerts @dimiboeckaerts]

Our new opinion piece on predicting #phage infectivity with #MachineLearning is out! A thread with some key points below 👇 or read the full article here: https://t.co/yHgCqe4Eio

[Yves Briers @BriersYves]

Happy #WorldPhageDay start of the #WorldPhageWeek! Watch this catchy testimonial about #phage #therapy recorded by our L.A.B. members @CliaPas1 @dimiboeckaerts #antibioticresistance #AMR @FWOVlaanderen @FbwUGent @ugent
Superbugs & Phage therapy https://t.co/o2NRBBWa7s