Anderson Thompson

[Dr. Brian Hoeflinger, MD @drhoeflinger]

I’m a retired brain surgeon and I wanna tell you why you feel like life is passing by. I just need one minute to explain this to you so hang in there.

Repetitive daily routines stop the brain from recording clear detailed memories. When every day looks the same, your brain does not track time the same as a clock does. It tracks change. If nothing new happens then days, months, and years start to blur together.

This is know as Time compression. When life lacks variety, your brain compresses past days together, making it feel like time is sped up.

To stop feeling like life is passing you by, add new experiences to your life. Break routine habits, like changing your daily home routine, taking a different route to work, or trying a new hobby.

Schedule small trips or plan new adventures so your days do not blend together.

Practice mindfulness by staying fully focused on what you are doing right now and not trying to race off to the next task.

Keep a journal and write down happy memories or memorable parts of the day before you go to sleep.

Take deep, calm breaths when you feel anxious or rushed to return your focus to the moment.

You can and you will retrain your brain to not feel like life is passing you by by following these few simple measures.

[Gut First @GutFirstHealth]

Spoke to at least 12 guys like this in the past year.

[DVLP @DVLPLONDON]

Goodbye clicking on Google Street View to check out the route!

In your browser, with https://t.co/2Zwyv0DEv9 you can actually drive anywhere in the world🚀
You can also create multiplayer races🚗🏎🚓

The world is generated ahead of you in real-time from OpenStreetMap data combined with satellite elevation data as you drive.

Just added a WIP of night mode and replaced the placeholder terrain/road textures with some nicer physics-based textures. Also now anywhere you go a million street lights will be added too. This is actually slowly starting to look like the promised Need For Speed + Google Maps
#threejs #gamedev #indiedev

Single player mode:
Just find a location, click anywhere on the map and click "Hop Here". After parachuting down hold X to call the car to the road.

Multiplayer mode:
Click on "Create race" and select start and finish points. A route will be plotted. Click on Share Race to get the link and start racing!

[Alvin @Alvin1492840]

A guy used AirPods Pro 2 for 2 years.

He pressed play. He pressed pause. He answered calls. He switched to noise cancellation on planes.

That was it. 4 features. On a $249 device with 30+.

His coworker a sound engineer at a recording studio borrowed them for 10 minutes at lunch and handed them back with a look.

"You've never opened Settings once, have you? Apple built 9 features into these that change how you work, sleep, hear, travel, and take calls. They're buried 3 menus deep and never mentioned in any ad. You've been wearing the world's most underused productivity tool."

He spent 11 minutes in Settings that evening.

His calls got clearer. His focus got deeper. He hasn't touched his phone during a workout since.

Here's every feature his coworker showed him 🧵

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. After 40, stop guessing about your health. These numbers tell you whether you're building a long, vibrant life — or quietly declining without knowing it.

I run these on myself. I run them on every patient I care about. Most are cheap bloodwork. All are available now. And together, they paint a picture no standard annual physical will ever give you. Print this. Bring it to your next appointment. Your 60-year-old self will thank you.
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𝗙𝗮𝘀𝘁𝗶𝗻𝗴 𝗜𝗻𝘀𝘂𝗹𝗶𝗻
Target: below 5 μIU/mL. Ideal: 3-4.
This is the 10-year warning bell your standard panel completely misses. Your glucose and A1c can look "normal" for a decade while your pancreas is working overtime to keep them there. Fasting insulin catches insulin resistance 5-10 years before your A1c moves. By the time A1c rises, the damage is already extensive.

𝗛𝗢𝗠𝗔-𝗜𝗥
Target: below 1.0.
Calculated from fasting insulin and fasting glucose. The single best measure of insulin sensitivity. Above 1.0 and your metabolism is already under strain. Above 2.5 and you're insulin resistant — even if every other number looks fine.

𝗛𝗯𝗔𝟭𝗰
Target: below 5.4%.
Not below 5.7% — that's the threshold where medicine calls you "prediabetic." By then you've been metabolically compromised for years. Optimal is below 5.4%. Blood sugar mastery is longevity mastery.

𝗧𝗿𝗶𝗴𝗹𝘆𝗰𝗲𝗿𝗶𝗱𝗲 : 𝗛𝗗𝗟 𝗥𝗮𝘁𝗶𝗼
Target: below 2. Ideal: below 1.
Your metabolic health crystal ball. This ratio predicts insulin resistance, cardiovascular risk, and metabolic syndrome better than any single lipid number alone. A ratio above 3.5 is a red flag regardless of what your total cholesterol says.

𝗔𝗽𝗼𝗕
Target: below 80 mg/dL for moderate risk. Below 60 for high risk.
I've written about this extensively. ApoB counts every atherogenic particle hitting your artery walls. A 2024 analysis found 54% of patients had dangerous levels that standard LDL testing completely missed. If you only know your LDL, you're driving with one eye closed.

𝗟𝗽(𝗮)
Test once in your lifetime.
100% genetic. 1 in 5 Americans are elevated. Triples heart attack risk independently of everything else on this list. Diet and exercise cannot lower it. The 2026 ACC/AHA guidelines now recommend everyone be tested. Most never have been.

𝗵𝘀-𝗖𝗥𝗣
Target: below 1.0 mg/L.
You can have perfect cholesterol and inflamed arteries silently preparing to rupture. hs-CRP measures the fire behind the plaque. The JUPITER trial proved that finding and treating inflammation saves lives — even when lipids look fine. If this number is elevated, your mouth, your gut, your metabolic health, and your visceral fat are the first places to investigate.

𝗩𝗶𝘁𝗮𝗺𝗶𝗻 𝗗
Target: 50-80 ng/mL.
Not the bare minimum of 30 your doctor accepts. Suboptimal vitamin D is linked to higher inflammation, weaker immunity, increased cardiovascular events, worse mood, and poorer outcomes across nearly every disease I treat. Supplement D3 with K2 — without K2, calcium deposits in your arteries instead of your bones.

𝗧𝗲𝘀𝘁𝗼𝘀𝘁𝗲𝗿𝗼𝗻𝗲 (𝗧𝗼𝘁𝗮𝗹 + 𝗙𝗿𝗲𝗲)
Men: optimal range 600-1000+ ng/dL total.
Declining testosterone is an independent predictor of cardiovascular death in men. It's tied to insulin resistance, arterial stiffness, visceral fat accumulation, and systemic inflammation. DHEA-S drops 10-20% every decade after 30. Tracking these isn't about vanity — it's evaluating your body's systemic resilience.

𝗕𝗹𝗼𝗼𝗱 𝗣𝗿𝗲𝘀𝘀𝘂𝗿𝗲
Target: below 120/80. Aim closer to 110/70.
Every point above optimal is cumulative arterial damage. Buy a home cuff. Measure morning and evening, seated quietly for five minutes, arm at heart level. White-coat readings in the office miss what's really happening. The smartest $40 investment in cardiac self-care.

𝗩𝗢𝟮 𝗠𝗮𝘅
Men over 40: above 40 mL/kg/min. Women over 40: above 35.
Cardiorespiratory fitness is the single strongest predictor of all-cause mortality — stronger than smoking, diabetes, or heart disease as individual risk factors. A landmark study in JAMA found that extreme fitness was associated with the lowest mortality with no upper limit of benefit. You can estimate VO2 max with a timed mile, a rower test, or a wearable. Get faster every year.

𝗡𝘂𝗺𝗯𝗲𝗿 𝗼𝗳 𝗠𝗲𝗱𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀
Target: as few as possible.
Every medication you're on should be earning its place. I just wrote about five commonly prescribed drugs that do more harm than good with long-term use. Bring your full medication list to every appointment. Ask: "Do I still need this?" Deprescribing is one of the most powerful and underused tools in medicine.
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Thirteen numbers. Most available through cheap bloodwork and simple tests. Get them once or twice a year. Here's what I want you to understand: these numbers don't just tell you where you are. They tell you where you're heading. A fasting insulin of 8 today becomes diabetes in five years. An ApoB of 120 today becomes a heart attack in ten. An hs-CRP of 3 today means your arteries are inflamed right now — regardless of how healthy you feel. The standard annual physical checks a fraction of these. It was designed to find disease that's already there. This panel finds the disease that's coming — years before it arrives.

What gets measured gets improved. Optimize with the foundation I write about every week on this platform:
Zone 2 cardio plus resistance training 3-4 times per week. High-protein whole-food nutrition. Sleep 7-9 hours — non-negotiable. Morning sunlight. Stress management. And the targeted supplements I've covered in detail — creatine, magnesium, CoQ10, D3+K2, glycine, omega-3, psyllium husk.
The breakthroughs coming in the next decade — gene editing for cholesterol, cellular reprogramming, senolytics that clear senescent "zombie" cells driving inflammation and aging, GLP-1 drugs rewriting metabolic medicine — will be most powerful for people who've already built the metabolic foundation to receive them.

The future of medicine is personalized. But it starts with knowing your numbers today. Print this list. Book the bloodwork. Own the data. Prevention isn't passive. It's the most aggressive thing you can do for the decades ahead.

[Eric Cole @erichustls]

If I got laid off tomorrow & had to replace my salary asap, here’s exactly what I’d do:

1. Go to Instagram and start a fresh account. Use a spare email. No one has to know.

[Khairallah AL-Awady @eng_khairallah1]

this is f*cking gold

How to build your first AI agent (Full guide)

if I had this a year ago, I would've shipped my first agent in a day instead of 2 weeks

in the right hands, this changes everything:

[Miles Deutscher @milesdeutscher]

Anthropic just literally spoon-fed you how to use Fable properly.

99% of Claude users missed it.

The way you need to prompt Fable is fundamentally different from all other AI models.

I translated their entire new Fable prompting handbook:

[Forge Mode | Self-Mastery® @HoliHappiness]

This is the perfect plan for a longer healthier life..

[Ruben Hassid @rubenhassid]

The new Claude 5 is the smartest AI you ever used.

And you have until June 22 to not pay for it:

1. Claude 5 'Fable' is a new kind of Claude. Understand it's much more than an upgrade.

2. It's the smartest thing you've ever talked to.

3. But Anthropic (Claude's parent company) gives us "free" access to it with the paid plan until the 22nd of June. After this, we'll probably pay, a lot.

4. Now what's so different? Everything, and nothing. You can do the exact same thing as before, but so much better, it feels drastically different.

5. It's slower, though. And it burns tokens (= credits) faster. So don't prompt it "Hi, how are you?"

6. Actually very important: give it your longest, hardest task ever. Aim for the end goal on the first prompt. Ask for the moon and watch it work.

7. On some of my tasks, Claude Fable-5 worked for 20 minutes straight. And it was good. Like coworker-I-should-probably-pay good. Try it.

8. A quick trick: use the "Research" mode (using the + at the bottom left of the chatbox) to ask for a very hard research task. I was seriously impressed.

9. Knowing what to ask is still the most important thing about AI. So yes, prompts matter still, sorry.

10. A trick I've been repeating forever: use the tool "AskUserQuestion" to make Claude ask you questions before answering, so it prompts it better.

11. If you give it good context (who are you, what you love or hate) before giving it a task, it's also much better at answering.

Quick reminder for people who don't know where and how to start, because I wrote about all of this:

✦ https://t.co/jw2qdIcjnh → my "Claude for Dummies".
✦ https://t.co/uWTpOI3Woc → my favorite Claude to work
✦ https://t.co/Vn60ElPZ2i → all of my Claude guides.

📩 Send this post to your colleague who still thinks Claude is the name of an old French guy.

[𝐓𝐡𝐞 𝐏𝐫𝐞𝐬𝐞𝐫𝐯𝐞𝐫 @ThePreserverofU]

THIS WILL SAVE YOUR LIFE ONE DAY:

1) Sudden panic attack → Touch something cold (water, phone, metal). Your brain switches from fear to safety mode.

2) Heart beating too fast → Cough 2–3 times forcefully. It resets your heart rhythm.

3) Can’t breathe properly → Put your hands on top of your head. Your lungs open up instantly.

4) Feeling dizzy → Focus on one spot and tense your legs. Blood rushes back to your brain.

5) Stuffy nose → Hold your breath and nod your head up & down slowly. Open blocked airways.

6) Sudden anxiety → Splash water on your face – it activates the calm reflex.

7) Can’t sleep → Exhale longer than you inhale (4–7 breathing). Your brain goes into sleep mode.

[Ruben Hassid @rubenhassid]

How to duplicate your (entire) brain in Claude:

Step 1. Download the Claude desktop app.
☑ Go to claude .com/download
☑ Set Opus 4.8 as default
☑ Turn ON Extended Thinking

Step 2. Open Claude Cowork mode.
☑ Cowork = where your brain lives
☑ Click the top left tab between 'chat' and 'code'
☑ Create your "Brain" folder inside

Step 3. Install Wispr Flow (it's free).
☑ Turns your voice → text
☑ Voice = faster and more honest
☑ Typing kills the truth. Dictate your context

Step 4. Run the 100-question taste interview.
☑ Paste Prompt 1 from https://t.co/kDGBpSF7Wh
☑ 100 questions, 7 categories
☑ Push past every vague answer. Be very specific

Step 5. Compress the dump.
☑ Paste Prompt 2 from https://t.co/kDGBpSF7Wh
☑ 20,000 words cost you 4,000 tokens
☑ Save your files as about-me .md file

Step 6. Write your anti-ai-writing-style .md.
☑ Every word you refuse to see: no "delve"
☑ Kill negative parallelism ("it's not X, it's Y")
☑ Without it, Claude writes like Claude.

Step 7. Write your my-company .md.
☑ Your goals, your focus, your hard no's right now
☑ Keep it > 1,000 tokens, update once a quarter
☑ This is your north star file.

Step 8. Test it in a blank chat.
☑ Open a fresh Claude chat (point to no folder)
☑ Run a prompt only you would write
☑ If it sounds like you → ship it

Step 9. Drop all 3 files into Cowork.
☑ Move all 3 files into your "Brain" folder
☑ Claude reads them on every single turn
☑ You stop prompting your brain. Your files do it.

Step 10. Port it everywhere.
☑ Upload to ChatGPT, Grok, Gemini
☑ Same files = same brain in every AI
☑ Hand it to your team or your ghostwriter

Step 11. Edit it forever.
☑ Install Obsidian (free)
☑ Open your Cowork folder as a vault
☑ You change. So must these files.

You'll resist this. It feels reductive. It feels scary.
You've built an identity on being hard to pin down.

But the mystery, when you look at it closely, is usually just being vague.

Copy my folder & download my 3 personal .md files:

Step 1: Subscribe for free at https://t.co/psB7XxB2Y4
Step 2: You will have two choices: free or paid.
Step 3: Choose the free tier. Don't pay for anything.
Step 4: Open your welcoming email. Reply to it.
Step 5: Trace the Notion link. Open '.md files' folder.
Step 6: Access my entire folder + 3 files template.
Step 7: Send this image to your team's channel.
Step 8: Read 2x newsletter per week (for free).
Step 9: Become the "AI guy" at work, forever.

[Eric Smith @Eric_Smith08]

Don't copy and paste answers from ChatGPT.

ChatGPT writing is easily detectable.

Use these prompts instead and see the magic:

[Dr. Shabbir @ItsDrShabbir]

I DON'T UNDERSTAND WHY MORE PEOPLE DON'T USE GOOGLE GEMINI TO RESEARCH STOCKS.

NOT FOR ADVICE.
NOT FOR PREDICTIONS.

BUT TO THINK CLEARLY BEFORE RISKING MONEY.

HERE ARE 10 DETAILED PROMPTS THAT I ACTUALLY USE 👇

[Anatoli Kopadze @AnatoliKopadze]

Godfather of AI: "If you sleep well tonight, you may not have understood this lecture."

This 47-minute lecture is the best thing I saw about AI in the last few months.

It will definitely help you understand how it actually works and where it's going.

Geoffrey Hinton built the neural networks behind every AI alive, then quit Google to warn the world about it.

The part nobody wanted to hear:

> AI is already developing abilities its creators didn't intend
> in most cognitive tasks it's already ahead of us
> the question is no longer if it surpasses us but when
> the only decision left is which side of that line you're on

Right now the average person opens Claude, types something, gets an answer, closes the tab.

They think they're using AI. they're using maybe 10% of it.

I went through his entire lecture, then mapped everything he described to what Claude can actually do today.

17 Claude features most people will never find on their own.

Full breakdown in the post below.

[SammyArmstrong @SammyRArmstrong]

Brad Pitt is 62.

He just spent two years training like an athlete to play an F1 driver.

But the reason he looks this good has almost nothing to do with that training.

Here are the 6 things he did:

[AI Frontliner @AIFrontliner]

🚨 BREAKING: Claude can now completely rewire your brain so you can learn anything at lightning speed.

Here are 7 Claude prompts to learn anything 10x faster:

[Sport boy @Sp_bo1]

هذا الرجل تسببت تمارينه في التخلص من انسداد قلوب آلاف الأشخاص، الآن أصبح هذا الفيديو سريع الإنتشار، كما اختفت شكوى بعض الأشخاص من آلام الظهر خلال 7 أيام. لا شيء يُمكن أن يكون أبسط من هذا التمرين، الذي ليس له أي آثار جانبية

[Francisco García @Fran_actua]

Tras 3 años usando Chat GPT me he pasado a Claude y puedo decir que ha multiplicado 10x mi productividad.

Aquí tienes 10 prompts que uso a diario que han transformado mi vida cotidiana y podrían hacer lo mismo por ti:

(Guarda esto antes de que se te pierda🧵).

[Khairallah AL-Awady @eng_khairallah1]

Anthropic engineer:

"You're not supposed to prompt Claude. You're supposed to build a system that prompts itself."

this is one of the best workflows I've seen in a long time

in this video she breaks down exactly how most people are using Claude:

- the 14% you lose to CLAUDE.md before typing a word
- the automation workflows most users don't know exist
- the daily task pipelines that run without touching the keyboard
- the daily workflows Anthropic's own engineers automated first

if you've been using Claude for more than a month and never left the chat window, you've been using one agent when you could be running a team of them

instead of another show tonight, watch this

make sure to bookmark it before it gets lost in your feed

the guide is in the article below